To answer the thread's title: No, speaking strictly on therapeutic / analgesic terms, not at all.
To talk a bit more generally about this, some notes I've experienced and learned about my own usage:
1) DIFFERENT benzodiazepines have different impacts on DIFFERENT opioids.
2) For example, for me, mixing alprazolam with oxycodone takes away a lot of that "stimulation" many associate with oxycodone and that in and of itself, makes oxycodone unique from other opioids (just like all opioids possess unique traits, at least to those of us who have more experience with opioids than we'd like to admit) and it becomes more sedating but neither the alprazolam or oxycodone are inhibited from doing what I'm taking them for: panic disorder&PTSD, and chronic pain, respectively.
3) Refer to the next note's first sentence, I'll even restate it since copying and pasting it is worth it if it means life or death:
tricomb said:
I do not condone the irresponsible and uninformed abuse of ANY drugs, especially combining CNS depressants, IIRC since RX drugs account for more deaths per year than all other drugs combined. However, most of these fatalities arose from reckless/careless/accidental combination of MULTIPLE CNS depressants that in this day and age, people should REALLY recognize by this point.... Benzodiazepines or Alcohol + Opioids when taken as a means of abuse or therapeutic relief via an incompetent/uncaring/uninformed prescribing physician
That being said, I, and other friends who are nearest and dearest to me, have reported
unreliable but statistically significant increases in the more, recreational aspects associated and sought out by addicts such as euphoria, nodding especially (allowing the user to escape from really, not deal with life and it's infinite problems that WILL arise because that's LIFE.), sedation, tranquility, etc. For Harm reduction purposes, I'm not going to be discussing which combinations of which opioids with which benzodiazepines produce the most euphoria or the most nod, etc.
4)
I do not condone the irresponsible and uninformed abuse of ANY drugs, especially combining CNS depressants, IIRC since RX drugs account for more deaths per year than all other drugs combined. However, most of these fatalities arose from reckless/careless/accidental combination of MULTIPLE CNS depressants that in this day and age, people should REALLY recognize by this point.... Benzodiazepines or Alcohol + Opioids when taken as a means of abuse or therapeutic relief via an incompetent/uncaring/uninformed prescribing physician, no matter how you spin it, this combination KILLS. It is LETHAL. I have experienced this myself, coming an inch from death after combining
the same doses of the same CNS depressants that I have been on for years. It is roulette. It killed my family and my friends.
-What is it? What is roulette? Roulette is reckless drug abuse. Roulette is what this forum seeks to destroy. As a harm reduction focus forum, we have to make sure that people are informed that they are spinning the barrel, (or dice if you prefer a sugarcoated analogy) when you mix CNS depressants, you have to take steps to ensure that you are not going to pose a danger to you or others. This is the most basic courtesy, decency, humanity, that a drug user can do to make up for all the reasons we use drugs, which of course vary highly on a case by case, patient by patient, addict by addict basis. One size does not fit all. One of my best friends and relatives of mine was taking therapeutic, as-directed doses of fentanyl patches in combination with clonazepam or lorazepam, there was no high that was being chased, only seeking ANY relief from the horrific autoimmune, malignant/cancer induced unrelenting chronic pain, anxiety, and nausea from the chemotherapy/radiation/surgeries.
--One day, seemingly out of nowhere, I found myself screaming, on the phone with 9-1-1 EMT dispatch, that we didn't have the four minutes the dispatch said it would take for the ambulance to get there, while trading off CPR duty with another relative. In my panic as I tore the house apart looking for some Narcan since we kept a lot of it on hand, and despite there previously having been vials of it + IV gear in practically every room of the house, I couldn't find any. I found Epinepherine, which was rapidly administered as CPR wasn't working after nearly breaking ribs while giving it, but it was too late.
You may be wondering why we kept Naloxone/Narcan so religiously in every part of the house, and it's the same point I was making before. This very thing had happened multiple times, my loved one had accidentally overdosed despite there being zero change in the doses of the CNS depressants that were prescribed and administered, no environmental changes/factors, to this day I do not understand why this happened because even after all of this.
To this day, I take my prescribed opioids and benzodiazepines in combination as directed/as needed. I don't take my prescriptions for recreational purposes anymore due to the impact my drug abuse was having on my ability to provide for my family and live up to (Or even be AWARE OF) my potential....but I have definitely noticed this very strange phenomenom, of seemingly random days playing out very differently than I was expecting.
One day for example, taking the same doses that have been taken for years, say....2mg alprazolam and 200mg morphine. There are random times and days where I will feel extremely sedated and respiratory depression strong enough to cause concern. Other days, it feels like those 2mg alprazolam + 200mg morphine felt like I took 5mg diazepam and 10mg hydrocodone, and I have excessive panic attacks and pain flares and feel the need to take more medication, but my experiences with how unreliable mixing such strong CNS depressants is enough to not give into such temptation and just ride out the pain and pull through the panic.
TL;DR read part 1.
I hope I get more answers to my original question (headline) but thanks for all the answers so far!