Mods feel free to move this to ADD if you feel it would be more appropriate there.
Preclinical data have shown ultralow-dose opioid antagonists to enhance and prolong opioid analgesia while reducing analgesic tolerance and physical dependence. Recent molecular pharmacology data show a mechanism of action to be the prevention of aberrant G protein coupling by opioid receptors that underlies opioid tolerance and dependence.
http://www.ncbi.nlm.nih.gov/pubmed/15943961
Patients with chronic pain who received oral naltrexone 100 microg BID in addition to their chronic intrathecal morphine infusions demonstrated the greatest improvement (p = 0.07) in their daily pain scores.
http://www.ncbi.nlm.nih.gov/pubmed/18027539
Has anyone attempted this? What dosing schedule would you recommend? I am trying to do something about opiate tolerance as my habit is becoming too expensive but I have no desire to stop using (the expense is the only negative aspect).
There is a wealth of posts on opiate potentiation but I am having trouble finding good info about this. I am just looking for recommendation for what to do in my situation and whether this might be a good option.
Preclinical data have shown ultralow-dose opioid antagonists to enhance and prolong opioid analgesia while reducing analgesic tolerance and physical dependence. Recent molecular pharmacology data show a mechanism of action to be the prevention of aberrant G protein coupling by opioid receptors that underlies opioid tolerance and dependence.
http://www.ncbi.nlm.nih.gov/pubmed/15943961
Patients with chronic pain who received oral naltrexone 100 microg BID in addition to their chronic intrathecal morphine infusions demonstrated the greatest improvement (p = 0.07) in their daily pain scores.
http://www.ncbi.nlm.nih.gov/pubmed/18027539
Has anyone attempted this? What dosing schedule would you recommend? I am trying to do something about opiate tolerance as my habit is becoming too expensive but I have no desire to stop using (the expense is the only negative aspect).
There is a wealth of posts on opiate potentiation but I am having trouble finding good info about this. I am just looking for recommendation for what to do in my situation and whether this might be a good option.