Amyl + Speed & E [interaction probs?]
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johnboy
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quite frankly i'd be more worried about the combination of three powerful stimulants, and the massivly increased chance of heart problems.
i've seen to many coroners reports with the words "a previously unknown heart condition contributed....." in them.
i've seen to many coroners reports with the words "a previously unknown heart condition contributed....." in them.
Personally i stear well clear of amyl during pills especially if they are taken in a hot environment.
Amyl makes u very hot, especially your head. I'd be worried about mixing it with XTC for this reason alone. Basically it feels like your brain is a volcano.
It can make u feel very sick, disorientated and it seems to take ages to cool down presumably due to the effect of MDMA on your ability to regulate your temperature.
[ 06 February 2002: Message edited by: Biscuit ]
Amyl makes u very hot, especially your head. I'd be worried about mixing it with XTC for this reason alone. Basically it feels like your brain is a volcano.
It can make u feel very sick, disorientated and it seems to take ages to cool down presumably due to the effect of MDMA on your ability to regulate your temperature.
[ 06 February 2002: Message edited by: Biscuit ]
phase_dancer
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I agree with jb.
MDMA increases systolic and diastolic blood pressure but doesn't increase ionotropy, which usually accompanies increases in heart rate. It equates to the heart pumping faster but with no increase in efficiency. This alone can create problems for someone with a predisposing heart condition.
Organic Nitrites (esters of nitrous acid such as amyl or butyl nitrite poppers) and nitrates (esters of nitric acid such as glycerol tri-nitrate or nitroglycerine) act as vasodilators. They basically do not increase significantly systolic or diastolic pressure, but work by reducing myocardial (cardiac muscle tissue) consumption of oxygen. Some may say they balance out the affects on the heart, but I don’t agree. Young fit people may be less likely to be affected by such extremes, but predisposed or older people are definitely at risk.
Your body produces small amounts of nitric oxide (NO) via enzyme action on the amino acid L-arginine. NO has various roles, some of which aren’t well understood, but it is known to act a cell signaling molecule.
The natural fate of nitric oxide, organic nitrites and nitrates, is to be converted into cyclic GMP. cGMP is involved in muscle relaxation. It is usually converted into GMP fairly rapidly by phosphodiesterse 6 (PDE-6). Viagra inhibits this enzyme, causing an increase in cyclic GMP, necessary for an erection.
Using Viagra and poppers can lead to SERIOUS INCREASES in levels of cGMP. Viagra should never be mixed with any nitrites or nitrates.
(Nitrous oxide is metabolized through a different route involving vitamin B12)
Nitrates and nitrites can have varying degrees of action and duration, depending upon the liver’s ability to process them. In other words you shouldn’t mix them with anything without first being sure of possible interactions.
Biscuit has mentioned the head-heat aspect. MDMA toxicity has been shown to be directly linked and relative to variations in normal body temp.
And who needs the head pressure? I’ve been rollin and had nitrite poppers shoved in front of me without realizing it (damn! I’ve been got twice like this - never dance with your eyes closed!)
Amyl? Not for me thank you.
-------------------------------------------
refs:
[url=http://www.web-books.com/MoBio/Free/Ch6B.htm[/url]" target="_blank]http://www.web-books.com/MoBio/Free/Ch6B.htm[/url]
Goodmans and Gilmans; The Pharmacological basis of theraputics, sixth Ed
Martini; Anatomy and Physiology, fifth Ed.
[ 06 February 2002: Message edited by: phase_dancer ]
MDMA increases systolic and diastolic blood pressure but doesn't increase ionotropy, which usually accompanies increases in heart rate. It equates to the heart pumping faster but with no increase in efficiency. This alone can create problems for someone with a predisposing heart condition.
Organic Nitrites (esters of nitrous acid such as amyl or butyl nitrite poppers) and nitrates (esters of nitric acid such as glycerol tri-nitrate or nitroglycerine) act as vasodilators. They basically do not increase significantly systolic or diastolic pressure, but work by reducing myocardial (cardiac muscle tissue) consumption of oxygen. Some may say they balance out the affects on the heart, but I don’t agree. Young fit people may be less likely to be affected by such extremes, but predisposed or older people are definitely at risk.
Your body produces small amounts of nitric oxide (NO) via enzyme action on the amino acid L-arginine. NO has various roles, some of which aren’t well understood, but it is known to act a cell signaling molecule.
The natural fate of nitric oxide, organic nitrites and nitrates, is to be converted into cyclic GMP. cGMP is involved in muscle relaxation. It is usually converted into GMP fairly rapidly by phosphodiesterse 6 (PDE-6). Viagra inhibits this enzyme, causing an increase in cyclic GMP, necessary for an erection.
Using Viagra and poppers can lead to SERIOUS INCREASES in levels of cGMP. Viagra should never be mixed with any nitrites or nitrates.
(Nitrous oxide is metabolized through a different route involving vitamin B12)
Nitrates and nitrites can have varying degrees of action and duration, depending upon the liver’s ability to process them. In other words you shouldn’t mix them with anything without first being sure of possible interactions.
Biscuit has mentioned the head-heat aspect. MDMA toxicity has been shown to be directly linked and relative to variations in normal body temp.
And who needs the head pressure? I’ve been rollin and had nitrite poppers shoved in front of me without realizing it (damn! I’ve been got twice like this - never dance with your eyes closed!)
Amyl? Not for me thank you.
-------------------------------------------
refs:
[url=http://www.web-books.com/MoBio/Free/Ch6B.htm[/url]" target="_blank]http://www.web-books.com/MoBio/Free/Ch6B.htm[/url]
Goodmans and Gilmans; The Pharmacological basis of theraputics, sixth Ed
Martini; Anatomy and Physiology, fifth Ed.
[ 06 February 2002: Message edited by: phase_dancer ]