will keep your liver enzymes busy whilst you are rolling these are called enzyme substrates. There are others that will completely inhibit the action of the enzymes. But this is a dangerous thing to play around with, as these reactions are completely unpredictable. Taking e is already unpredictable, given the difficulty knowing what is in the pill, and what amount. If you try to to enhance a pill by taking either an enzyme inhibitor or a substrate, the results could be lethal.
There is a well known case of a guy who died after taking 2.5 pills of e whilst on ritonavir, and anti-viral drug used for HIV that is an inhibitor of CYP2D6 and CYP3A4. On autopsy, his blood level of MDMA was 10 times the expected level. The ritonavir stopped the MDMA being broken down, so the levels just kept rising in his bloodstream until it killed him (see
here for more.)
Then there is the fact that each of us have different amount of these liver enzymes. There is a lot of variability between different people, so while your mate might be able to take MDMA with an enzyme substrate and appear unscathed (such as DXM, which is a substrate for both CYP2D6 and CYP3A4 and I strongly suggest no-one does this), it could be a different matter for you.
Here is a recent
thread from Health Q & A about the results of someone who took 2 pills which tested purple, along with zantac, a CYP2D6 inhibitor.
[ 24 January 2002: Message edited by: babydoc_vic ]