(Wouldn't that shit ya? "You are attempting to post to a thread that is now closed". Anyway here's a repost of what I tried to put in Legal Ecstasy to answer the questions there. I realise now that I've included a link to this thread within itself.)
OK so I got curious and looked some stuff up on this compound:
From the Other Drugs forum:
Phreex posted:
It's nothing but a bunch of herbal crap.. no recreational potential at all - it's overpriced, this new age grass eating hippie bullshit!
Info on SAM-e
From the Australia/Asia/NZ/Middle East Drug Discussion forum:
(Lou Caruana via Loco)
Sam-e boosts the production of neurotransmitters called serotonin and dopamine,which elevate a person's mood. Its active ingredient is an amino acid - the building block of proteins - found in high protein foods such as fish and meat.
Chemists Concerned Over New Super Depression Drug - ABC News Online
So... from what I can work out, SAMe is an acronym for a compound called S-Adenosylmethionine. This naturally occurring compound is potentially useful as an anti-depressant (acting as a methyl-donor rather than SSRI, or tricyclic) and has an efficacy superior to placebo, and comparable to that of tricyclic anti-depressants (Bressa 1994) with shorter lag time and fewer undesirable side-effects (Fava et al 1995). What's unclear to me from a quick search is whether this chemical is contraindicated with SSRI's or if it's action as a methyl-donor has nothing to do with seratonin. According to some sources it boosts seratonin levels, and according to the sources which say methyl-donor, seratonin isn't mentioned. Maybe someone else can help me out with my understanding on this?
GM Bressa, "S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies.", Acta Neurol Scand Suppl 154, 7-14, (1994).
M Fava, A Giannelli, V Rapisarda, A Patralia, GP Guaraldi, "Rapidity of onset of the antidepressant effect of parenteral S-adenosyl-L-methionine.", Psychiatry Res 56(3), 295-7, (1995).
BigTrancer
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Load universe into cannon. Aim at brain. Shoot.