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FDA OKs drug to fight opiate addiction

spini4

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Joined
Nov 18, 2003
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Doctors who treat drug addicts have a new option at their fingertips, thanks to a decision Tuesday by the Food and Drug Administration. The FDA gave its blessing to an injectable medicine, Vivitrol, as a treatment for opiate addiction. That's addiction to drugs including heroin as well as powerful prescription painkillers such as OxyContin.

Vivitrol is a time-release version of a drug called naltrexone, which blocks brain receptors from responding to opiates. Without that internal reward, the craving for the drug goes away.

The FDA was able to consider only a single controlled study, conducted in Russia, which found that Vivitrol was 50 percent more effective than a placebo in keeping opidate addicts clean for five months. However, some addiction specialists are already familiar with the drug, which was previously approved as a treatment for alcoholism, and thus available “off-label” for other uses.

In practice, the vast majority of addicts don’t get it. Most insurance companies won’t pay the cost of nearly $1,000 for each monthly shot; treatment often takes a year or more. Dr. Paul Earley, an addiction specialist at Talbott Recovery Campus, a center near Atlanta, says cost is a big hurdle and predicts the FDA decision will lead to much wider availability: “It’s going to help tremendously.”

The quality of addiction treatment varies widely, often depending on what a patient can afford. Still, for rich or poor, the basic approaches to opiate addiction are much the same: Group therapy, sometimes a 12-step program, sometimes “replacement” therapy – treatment that replaces the drug of abuse with a different drug, such as methadone, that leaves the user somewhat more clear-headed, but still addicted.

Naltrexone in pill form is another option, but Earley says daily medication is less effective in the long run. “Every day, the person that’s addicted to drugs has to make a decision on whether or not to use that day,” he says. “The majority of narcotic addicts will just stop taking the drug.”

There’s a crying need for better treatment. Federal statistics show a 12 percent increase in the number of people addicted to these drugs, between 2008 and 2009. An even more alarming trend: Between 2004 and 2008 the number of emergency room visits linked to painkillers more than doubled, according to the Centers for Disease Control and Prevention. Prescription narcotics are tied to 12 times as many ER visits as heroin.

continued at Doctors who treat drug addicts have a new option at their fingertips, thanks to a decision Tuesday by the Food and Drug Administration. The FDA gave its blessing to an injectable medicine, Vivitrol, as a treatment for opiate addiction. That's addiction to drugs including heroin as well as powerful prescription painkillers such as OxyContin.

Vivitrol is a time-release version of a drug called naltrexone, which blocks brain receptors from responding to opiates. Without that internal reward, the craving for the drug goes away.

The FDA was able to consider only a single controlled study, conducted in Russia, which found that Vivitrol was 50 percent more effective than a placebo in keeping opidate addicts clean for five months. However, some addiction specialists are already familiar with the drug, which was previously approved as a treatment for alcoholism, and thus available “off-label” for other uses.

In practice, the vast majority of addicts don’t get it. Most insurance companies won’t pay the cost of nearly $1,000 for each monthly shot; treatment often takes a year or more. Dr. Paul Earley, an addiction specialist at Talbott Recovery Campus, a center near Atlanta, says cost is a big hurdle and predicts the FDA decision will lead to much wider availability: “It’s going to help tremendously.”

The quality of addiction treatment varies widely, often depending on what a patient can afford. Still, for rich or poor, the basic approaches to opiate addiction are much the same: Group therapy, sometimes a 12-step program, sometimes “replacement” therapy – treatment that replaces the drug of abuse with a different drug, such as methadone, that leaves the user somewhat more clear-headed, but still addicted.

Naltrexone in pill form is another option, but Earley says daily medication is less effective in the long run. “Every day, the person that’s addicted to drugs has to make a decision on whether or not to use that day,” he says. “The majority of narcotic addicts will just stop taking the drug.”

There’s a crying need for better treatment. Federal statistics show a 12 percent increase in the number of people addicted to these drugs, between 2008 and 2009. An even more alarming trend: Between 2004 and 2008 the number of emergency room visits linked to painkillers more than doubled, according to the Centers for Disease Control and Prevention. Prescription narcotics are tied to 12 times as many ER visits as heroin.

continued at http://pagingdrgupta.blogs.cnn.com/2010/10/12/fda-oks-drug-to-fight-opiate-addiction/?iref=allsearch
 
They should approve Ibogaine in the USA.... But the ofcoarse there would be less addicts, thus less people buying drugs like suboxone and methadone.
 
This is not a new drug, its been around for a long time. It mite be a new formulation. As I state before, they used to have this drug as an implant and I've heard that people used to dig them out of their skin to get high.

All it does is keep you from getting high from opiates, but it doesn't help with anything else.

I don't want no one messin my Mu receptors, thats all I know.
 
my doc wants me on this. no fucking way. ULDN maybe. not this shit though.
 
Fuck that shit it blocks natural endorphins talk about dysporia
 
The quality of addiction treatment varies widely, often depending on what a patient can afford. Still, for rich or poor, the basic approaches to opiate addiction are much the same: Group therapy, sometimes a 12-step program, sometimes “replacement” therapy – treatment that replaces the drug of abuse with a different drug, such as methadone, that leaves the user somewhat more clear-headed, but still addicted

Hey you lazy fucks, do some damn research. You dont end up "still addicted" on methadone. Fuck, why cant the dumbass journalists get it thru their heads that there is a difference between dependence and addiction.

and u know wat? Who the fuck cares if you dependent on methadone or other OST drugs? You off dope! you dont live your life like a damn dopefeen no more! Maintenance work amazing for so many people and allows them to get their life back and to this day methadone is STILL the overwhelmingly most effective treatment method out of all of these that doctors been able to come up with, so while it aint perfect, its the best we got right now in many, many professionals opinions.

Second, you are still dependent when you take bupe anyways, which this article didnt manage to mention by name but you know thats part of the category they referring to when they talk about naloxone available in pill form. yea there is straight naloxone but these journalists dont know shit and most likely just confused suboxone with naloxone pills, etc. suboxone/bupe belons in the same category as methadone you still dependent on that too, so that shit aint nothing special.

Third, naloxone dont work by "blocking the receptor so the craving goes away." Anybody i know who ever took any naloxone containint product or any 'opiate blocker' includin myself, always had plenty of cravings. That shit dont make your cravings go away, it just makes you not be able to indulge them.

These fuckin hacks should learn a little bit more about the shit they are writing about before they put out more crap like this, everyday it just grows more and more like a giant unending pile of bullshit that cant b stopped, this flood of ignorant-ass drug talk that never fails to piss me off.
 
is this an ester of naltrexone? How do they get it to last a whole month?

I've been on daily naltrexone (ReVia) before. It sorta worked.

I don't know about this depot thing though. I can see people sentenced to monthly naltrexone shots and this thing completely supplanting all other forms of treatment because it can be forced on anybody and it doesn't produce happiness.

Any data on people trying to overcome this by taking humongous doses of dope? Sounds a little dangerous there. Somewhere along the line I see the drug company getting its tits sued off.
 
Wouldnt Fentanyl still get you high? What about bupe same principle would apply as to why they can put naltrexone in suboxone the whole higher binding thing right?
 
wtf they think Naltroxene is gonna be accpeted by people jumping off a heavy opiate habit?! hell no thats like saying heres some Naloxone, have fun detoxing.. I could maybe see this being beneficial to people coming off Suboxone and wants to make sure they stay clean...but thats about it..
 
Wouldnt Fentanyl still get you high? What about bupe same principle would apply as to why they can put naltrexone in suboxone the whole higher binding thing right?

It won't. Some have theorized that its receptor affinity should be high enough to overcome buprenorphine, but it isn't, at least not fully, dependent upon dosage of the bupe. I believe that it is, however, possible to overdose attempting to break through, so toying with this should be avoided.

Theoretically, the naloxone (not naltrexone) in Suboxone is inactive when the drug is administered.
 
wtf they think Naltroxene is gonna be accpeted by people jumping off a heavy opiate habit?! hell no thats like saying heres some Naloxone, have fun detoxing.. I could maybe see this being beneficial to people coming off Suboxone and wants to make sure they stay clean...but thats about it..

My psychiatrist told me he usually prescribes either the shot (vivitrol) or naltrexone in pill form to patients either after detoxing from dope or after coming off of suboxone. I told him no thanks i plan on being prescription free when i finish my suboxone taper, i have essentially been on an opiate blocker (suboxone) for 18 1/2 months and was only on dope for 8 months. I think its been long enough thank-you very much.
 
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