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http://www.sciencedirect.com/scienc...serid=10&md5=c74c45d4c7adc0ea77288aebd139d7ed
Spice: A never ending story?
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Rainer Lindigkeita, E-mail The Corresponding Author, Anja Boehmea, E-mail The Corresponding Author, Ina Eiserloha, E-mail The Corresponding Author, Maike Luebbeckea, E-mail The Corresponding Author, Marion Wiggermanna, E-mail The Corresponding Author, Ludger Ernstb, E-mail The Corresponding Author and Till Beuerlea, Corresponding Author Contact Information, E-mail The Corresponding Author
aInstitute of Pharmaceutical Biology, Braunschweig University of Technology, Mendelssohnstr. 1, 38106 Braunschweig, Germany
bChemistry Department, Central NMR Laboratory, Braunschweig University of Technology, Hagenring 30, 38106 Braunschweig, Germany
Received 21 April 2009;
revised 5 June 2009;
accepted 8 June 2009.
Available online 8 July 2009.
Abstract
On January 22nd 2009, the German Health Authorities prohibited several non-traditional cannabinoids, that proved to be the active components in popular “Bio-Designer-Drugs” like “Spice” and analogous products. The recent detection of CP 47,497-C8 in Europe and Japan documents that these products have already spread world wide. We synthesized several potentially interesting alkylaminoindoles (alkylchain C3 to C7) and isolated CP 47,497-C8 from “Spice Gold”. The compounds were purified and characterized by NMR and mass spectrometry methods. With the aid of these authentic references we were able to detect and quantify added psychoactive compounds in different herbal blends. All samples that were acquired before the prohibition in December 2008 contained either CP 47,497-C8 (5.4–11.0 mg/g) or JWH-018 (2.3 mg/g). Some samples acquired in March 2009, 4 weeks after the prohibition took place, still contained CP 47,497-C8 (3.0–3.3 mg/g) but JWH-018 was not detected anymore. Instead it was replaced by its non-regulated C4-homolog JWH-073 (5.8–22.9 mg/g). Furthermore some of the new products did not contain any non-traditional cannabinoids. To our knowledge this is the first report of the appearance JWH-073 as a new designer drug. The data and method presented here will facilitate and accelerate the detection of these compounds in complex matrices.
Keywords: Spice; CP 47,497-C8; JWH-018; Cannabimimetic; Alkylaminoindole; GC–MS