mr king
Bluelighter
- Joined
- Nov 11, 2004
- Messages
- 165
ICE[/B]
The long letter regarding U4Euh printed in Whole Earth Review (no. 59,
Summer 1988) was in response to their previous Winter 1987 piece by "R. U.
Sirius" of High Frontiers magazine which accidentally (?) gave U4Euh the
chemical structure for another drug, MDA, which is dissimilar in effects.
The nomenclature for U4Euh therein was given as 3,4-Methylenedimethoxy
Methamphetamine which the letter's author showed as "an impossible chemical
structure."
Without stretching this point too far, other "points of fact" laid down
in the response letter included "like crystal methedrine, it is almost
certainly capable of precipitating paranoid psychosis," and "Finally, U4Euh
is relatively untested, both scientifically and on the street," and so on.
The implications of "brain damage, kidney damage, heart damage and liver
damage" continue the barrage. Here is the Friendly Stranger's unprinted
response to "May You Never Sleep - Cognition Enhancing Drugs" from The
Whole Earth Review.
Feedback on Cognitive Activators from The Friendly Stranger
I was one of the first half-dozen or so people to enjoy U4Euh. I also
named it. That's a brand name. Clever? I thought so.
Someone else suggested the name Intellex.The description in the box is
TOTALLY incorrect. I doubt that R U. Sirius was guilty of so egregious an
error. If he was, he completely destroyed his credibility. U4Euh does NOT
fit the definition of "designer drug"; it was created decades before the
term was thought up, and it lay hidden in a journal article and patent.
Calling it a "stimulant" plays into the hands of DEA pigs and Nancy et al.
Saying it is "chemically related to MDMA" is like saying that a Model T
Ford is structurally related to a Formula One Ferrari. U4Euh is related to
MDMA only in that both contain a benzene ring and are composed of Carbon,
Oxygen, Hydrogen, and Nitrogen. There are tens, possibly hundreds, of
thousands of compounds which fit that description. It IS similar to
Pemoline. No, I am NOT going to reveal its exact molecular structure or
chemical name. Why should I?
I feel somewhat like the way John Sutter may have felt after word about
the discovery of gold leaked out. U4Euh was already out, in Florida, so it
was possibly only a matter of time. But my introduction of it at a major
gathering of free spirits, ax-hippies, "freaks," etc., to put it politely,
resulted in it getting out to California where the "baby birds" continued
to disobey instructions and take too much of it, unnecessarily winding up
at the Haight-Ashbury Clinic.
The DEA pigs learned about it and it was Emergency Scheduled. Mea
Culpa. Partly. I did the best I could with what I knew at the time. If I
knew then what I know now, I would NOT have been so generous, would NOT
have identified it, and would have required that people take it in my
presence.
writen by The Friendly Stranger
Here it is again. Some improvements to the PPA extraction process were surmised through empirical testing. A mixed solvent system of ethanol and water is now called for, and results in 100% extraction efficiency with super-speedy filtering. This works only for the *non-time-release* tablets,. The time release ones are a different story, I am told, and require much more processing time and crap to deal with.
Some other changes to help clarify the street nomenclature has also been added due to the e-mail I have received. Enjoy, and remember, if you want this to be a *real* FAQ, you guys have to send me more comments.
The 4-Methylaminorex pseudo-FAQ (beta)
Due to strangely increased demand for 4-Methylaminorex "recipes" that I have received by mail, I decided to compile a short document with the cognate preparation of this interesting compound. This may become a full-fledged FAQ in the future, depending on user response and outside input donated where this will undoubtedly be deficient.
A new clandestine, synthetic drug has been reported in Florida. Ice,
also known as U4Euh on the street, is synthesized from phenylpropanolamine
(PPA), a central nervous system stimulant, and cyanogen bromide, a
derivative of the poisonous gas, cyanide. The chemical name of Ice (U4Euh)
is 4-methyl aminorex.
Aminorex was researched as a diet aid between the 1950s and 1960s.
McNeil Laboratories received a patent and began testing it in 1964.
Aminorex was subsequently shelved because its stimulant properties were too
potent. When taken at lower doses, Ice produces amphetamine-like effects. A
hallucinogenic effect, similar to PCP, occurs at higher doses.
Some drug dealers are marketing Ice as cocaine or crystal
methampetamine. Ice may be taken in powder or liquid form. Most users snort
it or mix it in a drink. A small percentage of users administer it
intravenously. Florida law enforcement officials have identified
approximately 15 cases in central and northeast Florida involving the
powdered drug.
The first documented overdose fatally occurred in 1986. A 37-year-old
male with a history of clandestine chemical manufacturing was found dead in
a Florida hotel room. A plastic bag containing white powder was discovered
in his pocket. the bag was labeled "4-methyl aminorex free base. Not for
injection. For sacramental use only." An autopsy report confirmed the cause
of death to be a drug overdose.
As a result, the DEA classified Ice as a Schedule 1 drug on October 15,
1987. Prior to the emergency scheduling, a clandestine lab was seized in
Pennsylvania where Ice was manufactured. A Gainesville, Florida lab was
seized after Ice was banned. The state of Florida outlawed the substance in
1986.
*STANDARD DISCLAIMER*
This is for informational purposes only. It is being produced in order to illustrate the novel structure and effects of the aryl-oxazolines. Use this information at your own risk, I cannot be held responsible for what you do with it, etc... and so on.
Q1. What is Ice?
A1. Ice is a norepinephrine potentiator (neuromodulator class). It has a characteristic look and feel, like white opaque ice, hence the name. Ice is currently a Schedule I drug as designated by the DEA (Drug Enforcement Agency) which means it is felt to have NO medical use whatsoever. It was originally researched for appetite suppressant ability, but never pursued, probably because it's too much fun. Ice is also synonymous with "U4Euh".
Q2. Can Ice/U4Euh be made from amphetamine/methamphetamine?
A2. It is *technically* possible, but requires some backwards motions to get back to a sec. alcohol. At least one individual, in a personal communication to me, indicated that "they knew of someone who could convert crank [methamphetamine] into ice by washing it with something". This is not possible and more than likely is just a street name for clean crank (meth).
Q3. What kind of chemical is it?
A3. In drug parlance, which is notoriously Non-IUPAC compliant, Ice is synonymous with "Euphoria" (U4Euh), 4-Methylaminorex, or, chemically speaking: dl-cis-2-amino-4-methyl-5-phenyl-2-oxazoline. This is a tongue twister of a name, so I will explain and illustrate it with a cheap floozie of an ascii drawing.
//\
// \____ _____ ____CH3
| || | |
| || | |
\\ / O N
\\/ \ //
\//
|
N
/ \
H H
The numbering starts at the heterocyclic Oxygen and goes counter-clockwise. So the amine is at the 2 position, the methyl is at the 4 position, a phenyl ring is tacked on at the 5 position. Also, the 2-oxazoline part is often merely called oxazoline, as the double bond to the heterocyclic Nitrogen is implied.
It is interesting to note that all of the stereoisomers of 4-MAR are centrally active [1] (ie - it is not stereospecific in action).
Q4. What does Ice/U4Euh do?
A4. The document at Hyperreal.com describing the effects of Euphoria would be a good place to start. Anecdotally, it is said to help concentration and thinking - a sort of "make-you-smarter" drug, with a minor speed-like component to it. Time of action is around 4-6 hours (some say 14-16). Dosage varies but a good start is 20mg for a 150lb individual. It is smoked as the free base or the hydrochloride salt - both have relatively low melting points.
References
Journal of Forensic Sciences, v34, #4, 1989, "The Stereoisomers of 4-Methylaminorex", pp 963-979, Klein, Sperling, Cooper & Kram
Journal of Medicine Chemistry, v6, 1963, "2-Amino-5-Aryl-2-Oxazolines. Potent New Anorectic Agents", pp 266-272, Poos, Carson, Rosenau, Roszkowski, Kelley & McGowin
Euphoria Document
CRYSTLE METH
Overview
Methamphetamine (also known as speed, meth, crystal, crank, tina, and sometimes confusingly called ice) is a chemical widely known for its stimulant properties on the human body. It is frequently confused with other drugs that share similar effects, including amphetamine, 4-methyl-aminorex, ephedrine, caffeine, and other chemicals, both legal and illegal.
Terminology
In this document, we shall refer to the drugs by their common chemical names, rather than by "street names", since the street names do not have a one-to-one correspondence to actual chemicals. For example, the term "speed" can mean methamphetamine or amphetamine. The term "ice" is generally considered to apply to 4-methyl-aminorex, but is often used to refer to relatively pure (and in some cases, not so pure) forms of methamphetamine.
We shall use the term "methamphetamine" to refer to the substance in either its free base (i.e. simple, unadorned) or salt (usually hydrochloride) form. When precision is needed, we shall explicitly state one form or the other.
--------------------------------------------------------------------------------
Pharmacology
This is one of the most difficult sections to write, partially because there is very little "science" involved. The literature gives conflicting reports, due to the fact that many criteria are subjective, and probably also due to confusion over terminology.
The pharmacological effects of methamphetamine are very similar to those of similarly structured molecules.
Administration
Methamphetamine can be taken orally, snorted, smoked or injected, in approximately increasing order of immediacy of onset.
Onset
Onset can be immediate (in the case of injection), or can take as long as 30-40 minutes if ingested orally.
Duration
Duration is subjective, but is probably on the order of 4 - 8 hours. Delayed absorption (for example, due to oral ingestion) can prolong the effects relative to time of administration. Of course, larger doses last longer due to the fact that it is removed from the blood at a finite rate.
Plasma Life
The length of time that methamphetamine will stay in the plasma (blood) is between 4 to 6 hours. It can be detected in the urine one hour after use and up to 48 hours after use.
Dosage
A toxic reaction (or overdose) can occur at relatively low levels, 50 milligrams of pure drug for a non-tolerant user. Different peoples' metabolisms work at different rates, and drug strengths vary, so there is no way of stating a "safe" or "unsafe" level of use.
Effects
These include euphoria, hyperexcitability, extreme nervousness, accelerated heartbeat, sweating, dizziness, restlessness, insomnia, tooth grinding, incessant talking, and other effects.
Methamphetamine and other CNS stimulants have strong bronchodilation effects. Vasoconstriction (tightening of blood vessels) and pupil dilation are also common. Elevated blood pressure, heart rate, and other general symptoms of increased sympathetic nervous activity.
The physical effects are almost assuredly due to interactions between the amphetamine structure and human physiology, probably due to the similarity to adrenaline (epinephrine).
Mental capacity is not diminished directly by the drug. In fact, some studies have shown slight increases in mental capacity on simple tasks. It has been prescribed for attention deficit disorder, among other things.
Confusing reports here tend to center around the effects of fatigue on mental capacity.
Emotional responses may range from euphoria to anger and paranoia. Preliminary doses tend to produce the former, while continued use (e.g. for three or more days) tends to produce the latter.
It appears that these feelings may be linked to the neurotransmitters dopamine and/or serotonin, although we have not seen a good reference on this yet.
From Ephedrine or Pseudoephedrine
Making it from ephedrine or pseudoephedrine is possible. The only difference between methamphetamine and (pseudo)ephedrine is that damn alpha-hydroxy group. Reacting your ephedrine with thionyl chloride replaces the OH with Cl to produce N-methyl-alpha-chloroamphetamine as an intermediate. Hydrogenating this product is easy: use lithium aluminum hydride, sodium borohydride, or even hydrogen gas with nickel or platinum metal as a catalyst. The product of this step is N-methylamphetamine and HCl. Evaporate off the water and you have methamphetamine hydrochloride.
by (yogisin) and erowid.org
HAVE EDITED POST AND ALSO ADDED REFRENCES! [/B][/QUOTE]
The long letter regarding U4Euh printed in Whole Earth Review (no. 59,
Summer 1988) was in response to their previous Winter 1987 piece by "R. U.
Sirius" of High Frontiers magazine which accidentally (?) gave U4Euh the
chemical structure for another drug, MDA, which is dissimilar in effects.
The nomenclature for U4Euh therein was given as 3,4-Methylenedimethoxy
Methamphetamine which the letter's author showed as "an impossible chemical
structure."
Without stretching this point too far, other "points of fact" laid down
in the response letter included "like crystal methedrine, it is almost
certainly capable of precipitating paranoid psychosis," and "Finally, U4Euh
is relatively untested, both scientifically and on the street," and so on.
The implications of "brain damage, kidney damage, heart damage and liver
damage" continue the barrage. Here is the Friendly Stranger's unprinted
response to "May You Never Sleep - Cognition Enhancing Drugs" from The
Whole Earth Review.
Feedback on Cognitive Activators from The Friendly Stranger
I was one of the first half-dozen or so people to enjoy U4Euh. I also
named it. That's a brand name. Clever? I thought so.
Someone else suggested the name Intellex.The description in the box is
TOTALLY incorrect. I doubt that R U. Sirius was guilty of so egregious an
error. If he was, he completely destroyed his credibility. U4Euh does NOT
fit the definition of "designer drug"; it was created decades before the
term was thought up, and it lay hidden in a journal article and patent.
Calling it a "stimulant" plays into the hands of DEA pigs and Nancy et al.
Saying it is "chemically related to MDMA" is like saying that a Model T
Ford is structurally related to a Formula One Ferrari. U4Euh is related to
MDMA only in that both contain a benzene ring and are composed of Carbon,
Oxygen, Hydrogen, and Nitrogen. There are tens, possibly hundreds, of
thousands of compounds which fit that description. It IS similar to
Pemoline. No, I am NOT going to reveal its exact molecular structure or
chemical name. Why should I?
I feel somewhat like the way John Sutter may have felt after word about
the discovery of gold leaked out. U4Euh was already out, in Florida, so it
was possibly only a matter of time. But my introduction of it at a major
gathering of free spirits, ax-hippies, "freaks," etc., to put it politely,
resulted in it getting out to California where the "baby birds" continued
to disobey instructions and take too much of it, unnecessarily winding up
at the Haight-Ashbury Clinic.
The DEA pigs learned about it and it was Emergency Scheduled. Mea
Culpa. Partly. I did the best I could with what I knew at the time. If I
knew then what I know now, I would NOT have been so generous, would NOT
have identified it, and would have required that people take it in my
presence.
writen by The Friendly Stranger
Here it is again. Some improvements to the PPA extraction process were surmised through empirical testing. A mixed solvent system of ethanol and water is now called for, and results in 100% extraction efficiency with super-speedy filtering. This works only for the *non-time-release* tablets,. The time release ones are a different story, I am told, and require much more processing time and crap to deal with.
Some other changes to help clarify the street nomenclature has also been added due to the e-mail I have received. Enjoy, and remember, if you want this to be a *real* FAQ, you guys have to send me more comments.
The 4-Methylaminorex pseudo-FAQ (beta)
Due to strangely increased demand for 4-Methylaminorex "recipes" that I have received by mail, I decided to compile a short document with the cognate preparation of this interesting compound. This may become a full-fledged FAQ in the future, depending on user response and outside input donated where this will undoubtedly be deficient.
A new clandestine, synthetic drug has been reported in Florida. Ice,
also known as U4Euh on the street, is synthesized from phenylpropanolamine
(PPA), a central nervous system stimulant, and cyanogen bromide, a
derivative of the poisonous gas, cyanide. The chemical name of Ice (U4Euh)
is 4-methyl aminorex.
Aminorex was researched as a diet aid between the 1950s and 1960s.
McNeil Laboratories received a patent and began testing it in 1964.
Aminorex was subsequently shelved because its stimulant properties were too
potent. When taken at lower doses, Ice produces amphetamine-like effects. A
hallucinogenic effect, similar to PCP, occurs at higher doses.
Some drug dealers are marketing Ice as cocaine or crystal
methampetamine. Ice may be taken in powder or liquid form. Most users snort
it or mix it in a drink. A small percentage of users administer it
intravenously. Florida law enforcement officials have identified
approximately 15 cases in central and northeast Florida involving the
powdered drug.
The first documented overdose fatally occurred in 1986. A 37-year-old
male with a history of clandestine chemical manufacturing was found dead in
a Florida hotel room. A plastic bag containing white powder was discovered
in his pocket. the bag was labeled "4-methyl aminorex free base. Not for
injection. For sacramental use only." An autopsy report confirmed the cause
of death to be a drug overdose.
As a result, the DEA classified Ice as a Schedule 1 drug on October 15,
1987. Prior to the emergency scheduling, a clandestine lab was seized in
Pennsylvania where Ice was manufactured. A Gainesville, Florida lab was
seized after Ice was banned. The state of Florida outlawed the substance in
1986.
*STANDARD DISCLAIMER*
This is for informational purposes only. It is being produced in order to illustrate the novel structure and effects of the aryl-oxazolines. Use this information at your own risk, I cannot be held responsible for what you do with it, etc... and so on.
Q1. What is Ice?
A1. Ice is a norepinephrine potentiator (neuromodulator class). It has a characteristic look and feel, like white opaque ice, hence the name. Ice is currently a Schedule I drug as designated by the DEA (Drug Enforcement Agency) which means it is felt to have NO medical use whatsoever. It was originally researched for appetite suppressant ability, but never pursued, probably because it's too much fun. Ice is also synonymous with "U4Euh".
Q2. Can Ice/U4Euh be made from amphetamine/methamphetamine?
A2. It is *technically* possible, but requires some backwards motions to get back to a sec. alcohol. At least one individual, in a personal communication to me, indicated that "they knew of someone who could convert crank [methamphetamine] into ice by washing it with something". This is not possible and more than likely is just a street name for clean crank (meth).
Q3. What kind of chemical is it?
A3. In drug parlance, which is notoriously Non-IUPAC compliant, Ice is synonymous with "Euphoria" (U4Euh), 4-Methylaminorex, or, chemically speaking: dl-cis-2-amino-4-methyl-5-phenyl-2-oxazoline. This is a tongue twister of a name, so I will explain and illustrate it with a cheap floozie of an ascii drawing.
//\
// \____ _____ ____CH3
| || | |
| || | |
\\ / O N
\\/ \ //
\//
|
N
/ \
H H
The numbering starts at the heterocyclic Oxygen and goes counter-clockwise. So the amine is at the 2 position, the methyl is at the 4 position, a phenyl ring is tacked on at the 5 position. Also, the 2-oxazoline part is often merely called oxazoline, as the double bond to the heterocyclic Nitrogen is implied.
It is interesting to note that all of the stereoisomers of 4-MAR are centrally active [1] (ie - it is not stereospecific in action).
Q4. What does Ice/U4Euh do?
A4. The document at Hyperreal.com describing the effects of Euphoria would be a good place to start. Anecdotally, it is said to help concentration and thinking - a sort of "make-you-smarter" drug, with a minor speed-like component to it. Time of action is around 4-6 hours (some say 14-16). Dosage varies but a good start is 20mg for a 150lb individual. It is smoked as the free base or the hydrochloride salt - both have relatively low melting points.
References
Journal of Forensic Sciences, v34, #4, 1989, "The Stereoisomers of 4-Methylaminorex", pp 963-979, Klein, Sperling, Cooper & Kram
Journal of Medicine Chemistry, v6, 1963, "2-Amino-5-Aryl-2-Oxazolines. Potent New Anorectic Agents", pp 266-272, Poos, Carson, Rosenau, Roszkowski, Kelley & McGowin
Euphoria Document
CRYSTLE METH
Overview
Methamphetamine (also known as speed, meth, crystal, crank, tina, and sometimes confusingly called ice) is a chemical widely known for its stimulant properties on the human body. It is frequently confused with other drugs that share similar effects, including amphetamine, 4-methyl-aminorex, ephedrine, caffeine, and other chemicals, both legal and illegal.
Terminology
In this document, we shall refer to the drugs by their common chemical names, rather than by "street names", since the street names do not have a one-to-one correspondence to actual chemicals. For example, the term "speed" can mean methamphetamine or amphetamine. The term "ice" is generally considered to apply to 4-methyl-aminorex, but is often used to refer to relatively pure (and in some cases, not so pure) forms of methamphetamine.
We shall use the term "methamphetamine" to refer to the substance in either its free base (i.e. simple, unadorned) or salt (usually hydrochloride) form. When precision is needed, we shall explicitly state one form or the other.
--------------------------------------------------------------------------------
Pharmacology
This is one of the most difficult sections to write, partially because there is very little "science" involved. The literature gives conflicting reports, due to the fact that many criteria are subjective, and probably also due to confusion over terminology.
The pharmacological effects of methamphetamine are very similar to those of similarly structured molecules.
Administration
Methamphetamine can be taken orally, snorted, smoked or injected, in approximately increasing order of immediacy of onset.
Onset
Onset can be immediate (in the case of injection), or can take as long as 30-40 minutes if ingested orally.
Duration
Duration is subjective, but is probably on the order of 4 - 8 hours. Delayed absorption (for example, due to oral ingestion) can prolong the effects relative to time of administration. Of course, larger doses last longer due to the fact that it is removed from the blood at a finite rate.
Plasma Life
The length of time that methamphetamine will stay in the plasma (blood) is between 4 to 6 hours. It can be detected in the urine one hour after use and up to 48 hours after use.
Dosage
A toxic reaction (or overdose) can occur at relatively low levels, 50 milligrams of pure drug for a non-tolerant user. Different peoples' metabolisms work at different rates, and drug strengths vary, so there is no way of stating a "safe" or "unsafe" level of use.
Effects
These include euphoria, hyperexcitability, extreme nervousness, accelerated heartbeat, sweating, dizziness, restlessness, insomnia, tooth grinding, incessant talking, and other effects.
Methamphetamine and other CNS stimulants have strong bronchodilation effects. Vasoconstriction (tightening of blood vessels) and pupil dilation are also common. Elevated blood pressure, heart rate, and other general symptoms of increased sympathetic nervous activity.
The physical effects are almost assuredly due to interactions between the amphetamine structure and human physiology, probably due to the similarity to adrenaline (epinephrine).
Mental capacity is not diminished directly by the drug. In fact, some studies have shown slight increases in mental capacity on simple tasks. It has been prescribed for attention deficit disorder, among other things.
Confusing reports here tend to center around the effects of fatigue on mental capacity.
Emotional responses may range from euphoria to anger and paranoia. Preliminary doses tend to produce the former, while continued use (e.g. for three or more days) tends to produce the latter.
It appears that these feelings may be linked to the neurotransmitters dopamine and/or serotonin, although we have not seen a good reference on this yet.
From Ephedrine or Pseudoephedrine
Making it from ephedrine or pseudoephedrine is possible. The only difference between methamphetamine and (pseudo)ephedrine is that damn alpha-hydroxy group. Reacting your ephedrine with thionyl chloride replaces the OH with Cl to produce N-methyl-alpha-chloroamphetamine as an intermediate. Hydrogenating this product is easy: use lithium aluminum hydride, sodium borohydride, or even hydrogen gas with nickel or platinum metal as a catalyst. The product of this step is N-methylamphetamine and HCl. Evaporate off the water and you have methamphetamine hydrochloride.
by (yogisin) and erowid.org
HAVE EDITED POST AND ALSO ADDED REFRENCES! [/B][/QUOTE]
Last edited:
![:\](https://bluelight.org/xf/BL_Images/Orig_Emoji/wrygrin.gif "wry grin :\")
