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Xyrem, straight from DEA

S

Stargazer59

Bluelighter
Joined
Aug 26, 2006
Messages
217
Location
Jacksonville, FL
What is XyremÒ

XyremÒ , a central nervous system depressant, is a FDA-approved drug containing GHB with Orphan Drug Status. It is approved to reduce the incidence of cataplexy (weak or paralyzed muscles) and to improve daytime sleepiness in patients with narcolepsy. The FDA approved XyremÒ for marketing and distribution in the United States under Section 505 of the Food, Drug, and Cosmetic Act. As provided for in Title 21, CFR, Section 1308.13(c)(5), any drug containing gamma-hydroxybuturate for which an application is approved under Section 505 of the Federal Food, Drug, and Cosmetic Act, is a Schedule III controlled substance. As such, any authorized persons manufacturing, distributing or dispensing GHB-containing FDA-approved drug products must register in Schedule III, maintain Schedule III security, comply with the labeling requirements of 21 CFR 1302.03-1302.07, comply with all inventory and recordkeeping requirements and comply with all Schedule III prescription requirements.

While XyremÒ is a Schedule III controlled substance, GHB, including its salts, isomers, and salts of isomers, remains a Schedule I drug. Abuse of XyremÒ will be subject to Schedule I criminal sanctions per the "Hillory J. Farias and Samantha Reid Date-Rape Drug Prohibition Act of 2000" (PL106-172). Thus, any person who sells, distributes, or gives XyremÒ to someone else, or who uses XyremÒ for purposes other than what it is prescribed for, may be punished under the federal and state law.

http://www.deadiversion.usdoj.gov/pubs/nwslttr/2003winter/


Anyone on this stuff?
 
^lol


I was once prescribed to thi . . .

*SLEEPS *


. . . seriously though Survival, if there were narcoleptics they could probably be found on this board, this place seems to attract some strange characters 8)
 
Xyrem is sodium oxybate AKA GHB sodium salt. I've come across this stuff and it works as well as regular GHB. If you snort it, it works VERY well...
 
It WAS a lot to snort, but it wasn't so unpleasent as you would think. I was just given some in a club as a gift, and it sure helped coming down off of pills. I really don't like the GHB high, though it's useful for getting off alcohol with...
 
I'm with Survival, I believe narcolepsy is an *extremely* rare condition, and that most conditions resembling it have underlying conditions causing like symptoms (usually sleep apnea and the like, that cause excessive daytime sleepyness, but not neccessarily uncontrollable boughts of falling asleep).


That being said, without blowing the top off (sure its the internet, but like I said its very rare) I do know a coworker in a nearby retail location with the condition. He also probably has apnea (he is very large) but I've watched him go from wide awake to out back to wide awake in 0 seconds flat. I've also heard first hand reports of him doing this while driving. My understanding is that the condition is based on this, that if the activity in the concious brain drops too far, that it just shuts down completely.

So, back on topic, I was interested in it and asked him about it. He told me about getting medicated once to stay awake, and that it made him irriate and edgy and they had to RX other meds for that and to help him sleep (he didn't give me any names other than ambien, as he couldn't remember), and that he ended up on like 8 scripts just for the condition.

He also mentioned that the battery of tests needed to go through because of the meds they RX'd for the condition (he told me about a sleeping pill "that rocked, man, I mean it was like being drunk but you still had some control, but you were really really really drunk" I thought he was talking about a barb of some sort but it could've by xyrem, that he took before the ambien) were too difficult to obtain, because of all the paperwork the drs had to go thru they didn't want to deal with it.

Just my .02.
 
I have been diagnosed a narcoleptic. Actually I only have hypersomnia, narcolepsy is when you fall asleep even when you strive to stay awake. The doc overdiagnosed a bit to be allowed to prescribe me Modafinil, a controlled substance in these parts of the world.

GHB is a sleep-inducing drug isn't it? So it would be the last thing to give narcoleptic patients.

narco = sleep
leptic = falling into
 
^For the same reason they give ADHD people speed, I guess....
 
hey i know this threads probably dead but thought i would chime in since i just found it. I was diagnosed with narcolepsy about 2.5 years ago. I had tried just about every sleeping pill out there before the official diagnosis came in, ambien, sonata were the 2 that i was on the longest. anyway my case isnt like duece bigalo chick or anything.

I dont fall asleep uncontrollably while driving/walking/moving around etc. But if i stop movin for even 5 minutes like watching tv or just sitting in a chair resting theres a very very high chance i will fall asleep. also when i am sleeping at night i go in and out of deep rem sleep very often. i can usually remember 5-10 dreams when i wake up everyday.

anyway the tests they used to diagnose it was a sleep study. i had to go in to the sleep specialists office one night and they glued electrodes to my head/face/chest to monitor me while i slept. They also had little ankle bands to see when my legs moved. and a nose thing like in hospitals to monitor my breathing for apnea.

so anyway my scripts for this are fucking amazing. I get 40mg of dextroamphetamine per day, can take up to 4 10mg pills whenever im feeling sleepy. and i get 10 grams of xyrem every night. 6 grams to start with and then 4 grams i take like 4 hours later usually. This stuff is amzing for sleep. can knock me out even off 40mg of dextro. crazy good stuff for its purposes. not to mention how fun it is %)
 
xxl said:
GHB is a sleep-inducing drug isn't it? So it would be the last thing to give narcoleptic patients.

narco = sleep
leptic = falling into
Click to expand...


the theory behind this is that GHB promotes deep stage (alpha-wave?) sleep, which is what narcoleptics never really get, thus helping the condition somehow.
 
The information on Xyrem that I have read, indicated to me that one must undergo a background check to participate in what the company that produces this Schedule 3 drug calls a Xyrem Success Initiative. This is a program in which the patient must fill out the forms from Jazz Pharmaceuticals. It sounds like a great deal of hoops just simply to be treated for narcolepsy/cataplexy.


Xyrem Physician Success Program
 
This seriously concerns me, as GHB causes the worst physical dependence of all drugs in my opinion AND experience. The dependence is quick to set in and is at least as dangerous (if not more) than barbiturate withdrawal.

If I were a doctor, I'd rather give my patients amphetamines than give them this serious and devastating addiction. And this is saying a lot, since amphetamine addiction is no joke either.

The part that concerns me is that it seems the healthcare system, and the public at large, are unaware of these dependence issues and most healthcare professionals have no idea how to deal with GHB withdrawal, which involves at least 4 neuronal systems (ACh, GABA, GHB, and DA). It probably causes neuro-endocrine damage as well since my sexual health has never recovered even 2 years since I broke my addiction with GBL/GHB.

I don't understand the use of GHB as a sleeping aid. It may work the first few times, but when you find yourself waking up every 2 hours with horrible panic and shaking and cannot go back to sleep unless you redose, you're already in deep shit.
 
Jamshyd: I think you are right on target. That is, addiction to CNS depressants is far worse (and far more dangerous medically) than addiction to CNS stimulants. Where amphetamine withdrawal might be a bitch (you'll be depressed, sluggish, cognitively foggy), withdrawal from alcohol, GHB and/or barbiturates can be fatal.
 
Riemann Zeta said:
withdrawal from alcohol, GHB and/or barbiturates can be fatal.
Click to expand...

Yeah, the GABA affecting drugs are dangerous indeed...I believe that benzodiazepine WD can be fatal as well. I need to do some personal research to see why this is. Perhaps it is related to the inhibition of the GABA itself? If someone has somewhere I can cross reference, please PM me with that information.
 
I would think adderal Insant release pills and xanax for sleep would be good. Xanax for sleep works quiet well even though it's short acting.
 
brainiacthemaniac said:
The information on Xyrem that I have read, indicated to me that one must undergo a background check to participate in what the company that produces this Schedule 3 drug calls a Xyrem Success Initiative. This is a program in which the patient must fill out the forms from Jazz Pharmaceuticals. It sounds like a great deal of hoops just simply to be treated for narcolepsy/cataplexy.
Click to expand...


The patient doesn't have to fill out anything, but rather the doctor has to go through the process of registering with them in order to be approved to prescribe it.

Takes about a week, maybe a bit less, before you have the xyrem in your hand. they do call you and ask some questions to verify that you understand how to take the medicine, safety information, etc. They ship it out once it's confirmed you understand.

There's no background check. A criminal past or past with abuse does not legally bar you in any way from receiving a med that a doctor deems necessary for your health (it does however make the doctor more wary to prescribe it).

I'm narcoleptic and receive 130mg of adderall daily and doses of ghb at night. It works for what it's supposed to. It reduces cataplectic episodes an average of around 70% in incidence when dialed in.

about 1 in 2,000 - 3,000 people have narcolepsy. it does not consist of just falling asleep and being tired all the time. do a search, you'll learn a lot about it (REM intrusion, sleep paralysis, cataplexy, for example).

With people who are afflicted with this disorder, it can be cripplingly debilitating. the FDA approves it under the way it's set up, it's toxicity is low enough to not be an issue provided one is not intentionally abusing it / trying to OD (most think the opposite. again, look it up.), and it proves itself by doing precisely what it claims in the majority of patients. Some of us need it.

I don't particularly get how in the grand scheme of things my adderall scrips are CII and xyrem CIII, and xyrem is such a bigger hassle, but I guess that's life.

ehh, tired of typing....going to just submit now and go to sleep.

edit- GHB does not affect GABA receptors.
 
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