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WIN 25,978 AKA: Amfonelic acid

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vicapro

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WIN 25,978 / AFA

IUPAC-Name: 1-ethyl-4-oxo-7-(phenylmethyl)-1,8-naphthyridine-3-carboxylic

CAS#: 15180-02-6

Just today saw this in stock on my most reliable vendors list. Im curious if anyone has tried this chemical and if anyone knows the dosages involved because it isnt that cheap compared to other dopamine agonists.
 
It's a DRI, not a dopamine agonist. Did you even google for one minute before asking?
 
I've read a few people's experiences of it and they were mostly, depending on your expectations - especially considering I recall some hailing this compound as "the next meth" a few years back - underwhelming. Most described it as a somewhat more potent version of modafinil rather than anything remotely close to meth or even speed, and I didn't see anyone commend it as anything close to the holy grail of recreational drugs some had imagined it to be.

Personally I see it as a potentially interesting drug to try, since it seems to be quite a productive stimulant that lacks most of the typical stim side-effects (that quickly become overwhelming for me and make my life hell), but the fact that it allegedly also acts as a potent antibiotic turns me off trying it.
 
Nagelfar said:
Technically, they're called "indirect agonists", so I wouldn't say you were too far off the mark.
Click to expand...

I don't care if i called it an opioid agonists he needs to take a moment to think before he writes because obviously i came to this thread looking for the brightest to give me insight on a new chemical and the first poster offers no helpful info; instead he wrongly accuses me of not even googling the chem first because i harmlessly used the wrong term in relation to its action on dopamine. Roi, in the future i suggest you don't post information that is not only mainly impertinent to the question but more importantly instead of nicely correcting my misinformation you comes across in a disrespectful mannor accusing me of not even trying to find the answers to my questions on my own. I specifically came to the neuroscience thread because i was having trouble finding studies/experiences pertaining to this compound and my intentions were definitely not to get insulted by the first person who posted. And thanks to everyone else who posted in a respectful mannor.
 
Amfonelic acid is a fluoroquinolone antibiotic so it's reeeaaally not something that should be used regularly. By anybody. Because there's a risk that any bacteria in your body will be exposed to it and develop a resistance to fluoroquinolones. Which affects everybody, not just the user, as antibiotic resistance is something that can spread through populations of bacteria from species to species. There aren't a lot of reports of it's use online, although there are a couple over on reddit /r/nootropics (I believe it's /r/nootropics) that make it sound pretty nice. I've always found it interesting that companies who sell nootropics and other non-recreational drugs occasionally stock AA, since it doesn't really fit with other noot's and more fits the definition of a 'research chemical'. I'll probably give it a shot at some point and post my experience online. It's just something that shouldn't be taken more than just a few times, so be forewarned.
 
Yet to get to the point of this substances being an antibiotic in its own right is far past the "normal" dose of it. And having had a fair amount of it (Not recreationally) 10mg's was completely active. I remember posting about this substance in the past and having more of an opinion. Yet unless (If memory serves me correctly) the actual antibiotic effects don't kick in until the hundreds of mg's. Also pretty much anything "new" that comes out as a nootropic can also be called a research chemical. Just depends which label/provider is selling it as.
 
Amfonelic doesn't have a great track record of safe use in humans. Anecdotally, it seems to have a high risk for stimulant psychosis. Part of the problem may be that it is relatively selective for dopaminergic effects; the lack of noradrenergic effects may make it easier to push the dose.
 
^^
Yup.

Like most USDRI's the complete lack of actual physical stimulation reduces its function to little more a Dopaminergic delusion generator that also doubles up as a great way to annihilate the gut flora while driving selection towards resistant strains of pathogenic bacteria.
Not really the kind of compound to be used by those who shove grams of powder up their nose if there's even the slightest chance it's psychoactive.
 
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