Tryptamines Will Lexapro interact in a negative way with magic mushrooms?

[mpodder]

Is it possible (or risky rather) to take mushrooms while taking Lexapro? I just started taking Lexapro earlier this year and it is my first ever SSRI, has been working well at the lower dose of 10 mg. I have been curious about trying shrooms for a while now but have seen a few mixed things about combining an already serotonin-releasing drug with them. I am mostly interested in microdosing, or taking a lower dose of the actual shrooms, but am curious how likely it is to get serotonin syndrome or not have any effects. I suppose its case-by-case, but can anyone give any insight into this?
Thanks!~
(Not sure if this is important, but I am a regular cannabis user, have only ever smoked weed and actually really love it combined with Lexapro)

 

[HRopiate]

I would think THC has a significantly greater impact on serotonin than shrooms but I don't know as much about them. To my knowledge I thought THC and MDMA primarily affect the neurotransmitter serotonin compared to most other drugs. Since you are well habituated to THC, that could impact lexapro but you find it to be beneficial. I doubt you have anything to worry about. Remember expectations impact things more than most other factors. Be responsible and remember to titrate up rather than start high and then go lower.

 

[Nas47]

All AD drugs could react negative with shrooms.Bigger the dose-bigger chance of unwanted reactions.Even mdosing could led to a problem.My advice-stay away from fullblown trip,if you take antidepresants

 

[Mycophile]

All AD drugs could react negative with shrooms.Bigger the dose-bigger chance of unwanted reactions.Even mdosing could led to a problem.My advice-stay away from fullblown trip,if you take antidepresants

No, it's not that big a deal.

Every time I've tripped on anything, including several times on shrooms, I was on Prozac or Lexapro.

It's not dangerous, it's just that it can weaken the effects of the trip, but then you just need to take more shrooms.

It's not like an MAOI or something like that or a serotonergic agent like MDMA. There's nothing dangerous about mixing SSRIs with tryptamines.

 

[Mycophile]

Is it possible (or risky rather) to take mushrooms while taking Lexapro? I just started taking Lexapro earlier this year and it is my first ever SSRI, has been working well at the lower dose of 10 mg. I have been curious about trying shrooms for a while now but have seen a few mixed things about combining an already serotonin-releasing drug with them. I am mostly interested in microdosing, or taking a lower dose of the actual shrooms, but am curious how likely it is to get serotonin syndrome or not have any effects. I suppose its case-by-case, but can anyone give any insight into this?
Thanks!~
(Not sure if this is important, but I am a regular cannabis user, have only ever smoked weed and actually really love it combined with Lexapro)

I've had quite a few full blown trips on shrooms and LSD on prozac and at much higher doses and was fine.

I don't believe I tripped during the few years I was taking Lexapro, but they are so closely related it should be the same thing most likely. It's not dangerous, but you are likely to need more shrooms. Go slow.

 

[Nas47]

No, it's not that big a deal.

Every time I've tripped on anything, including several times on shrooms, I was on Prozac or Lexapro.

It's not dangerous, it's just that it can weaken the effects of the trip, but then you just need to take more shrooms.

It's not like an MAOI or something like that or a serotonergic agent like MDMA. There's nothing dangerous about mixing SSRIs with tryptamines.

I would not doing it....except for low dose/not for trip....not why i am scared,but because i don't wanna mix shits like ssri with these little beauties.It's ugly somekind&disrespectful......but that is just my rule...don't touch you

 

[Mycophile]

I would not doing it....except for low dose/not for trip....not why i am scared,but because i don't wanna mix shits like ssri with these little beauties.It's ugly somekind&disrespectful......but that is just my rule...don't touch you

Well that's fine that you don't want to do it, but I've been on Prozac since age 14 and can't get off it right now, so I either trip on my prozac or I don't trip at all.

Every drug I have ever used I have been on prozac or lexapro, and it's not easy to get off of, so yeah, that's a choice I've had to make.

But I'm just telling this guy that from what I know it isn't dangerous, and many other people on this forum have confirmed this, but you need to be careful cause many other substances mixed with SSRIs can be.

Most likely, all that happens is it weakens your trip somewhat.

Many of us don't have a choice: we need our SSRIs and they are very addictive and hard to get off of, so we have to make this choice, and I wouldn't want someone to miss out on how great shrooms are because they can't get off their SSRI.

There's little evidence that SSRIs are actually dangerous mixed with shrooms or LSD.

 

[Nas47]

I am on zoloft.Never toke any othe ad drug.....and I ain't got tripping long,long time ago,not because of zoloft,but pain meds.Do only low doses regimes from about couple of few consecutive days.If you have not any problems combining this two....then ok.You know better than me how you react on this.Just for me takin' shrooms together with some other psychoactive substance(except a little bit of weed) is not the same,when you are fully drug free.

 

[Skorpio]

It won't be dangerous like mdma and ssris but you likely won't trip or will have a severely attenuated trip.

I would not immediately take a higher dose, because it seems that the dose that makes people trip on antidepressants tends to make people trip very hard in kind of a delusion kind of way.

Id advise a lot of caution.

 

[Mycophile]

It won't be dangerous like mdma and ssris but you likely won't trip or will have a severely attenuated trip.

I would not immediately take a higher dose, because it seems that the dose that makes people trip on antidepressants tends to make people trip very hard in kind of a delusion kind of way.

Id advise a lot of caution.

This is probably good advice, but I'll just reiterate that every time I've tripped it's been on an SSRI and shrooms and LSD do work on prozac and lexapro. I think to use the term "severely attenuated" is a bit of an exaggeration.

I trip off an 8th of shrooms, or 2-3 hits of LSD. I think it affects shrooms more than LSD as just 2 blotters were enough for tons of visuals years back on a similar dose of prozac to what I still take. I do plan on taking more shrooms next time to achieve better effects, but most say visuals don't happen on shrooms most of the time for most non-medicated people anyway, which is usually the one thing I don't get off shrooms but do get off LSD. My shroom trips are usually very peaceful trips where everything seems great with the universe and I get an intensely pleasurable body high.

For many of us on SSRIs we don't know what we are missing. I wouldn't even know what to compare a non-SSRI influenced trip to, because all of them have been, so I have no frame of reference to compare to, but I think being someone with anxiety, OCD and depression that it has helped me, and I totally see why it's being used as medication for people with mental health issues.

But yes, I'd also advise caution for the OP and to go slow.

 

[Mycophile]

I am on zoloft.Never toke any othe ad drug.....and I ain't got tripping long,long time ago,not because of zoloft,but pain meds.Do only low doses regimes from about couple of few consecutive days.If you have not any problems combining this two....then ok.You know better than me how you react on this.Just for me takin' shrooms together with some other psychoactive substance(except a little bit of weed) is not the same,when you are fully drug free.

I'm sure it's not the same, but I have nothing to compare it to since that's always how it's been for me.

I don't know if I'll ever get off prozac because of my issues, so I figure either I get a lighter more moderate trip, or no trip at all.

 

[TimTim1993]

The first time I did shrooms I was on psych meds, I ate half an eighth and I tripped really hard for 3 hours, I had full blown visuals and everything. Then 12 years later I did shrooms while on Effexor XR and I definitely tripped but it was more of a body high, and mind and emotional high, I still had visuals but it wasn't as intense as the first time. But the strains were different. The first time I think they were Penis Envy's, they were little thick stems and there had to be like 12 of them, they were small like an inch or so each. No caps but I tripped really hard off half an eighth. Now 12 years later I definitely think they were golden teachers