Misc Will a chemical version of Kava be invented?

[calmcloud]

Hello,

Well you know the way how mushrooms have been used by humans for thousands of years, and only around 50 years ago LSD was discovered.

Kava:
From my understanding Kava is a plant they use on a island, and its chemical proprieties have to do with gaba and other.

But do you think that, like the way mushrooms -> lsd (just an example)
what about kava -> some new sedative drug ??? (And yes, I know that the drug inside Kava is Kavalactone and what not, but you know the way how LSD and Psilocybin are very related but not the same. And how LSD is a "chemical" version of Psilocybin.

Do you think that maybe there could be some chemical versions of Kava discovered by scientists out there?


Because with all the drugs around the world, they use it naturally. Even look at India, and how calm they are.


Everyone just needs to be calm and stop all the conflict and violence in the world.


ok,

 

[f33lg00d]

There are plenty of GABAergic synthetic chemicals. Like benzos or gabapentin.

 

[Solipsis]

I'd personally prefer analogues of theanine and not kavalactones. At least theanine is quite safe AFAIK. Unfortunately it is also milder than kava and the MOA is more poorly understood.

Just read wiki of methysticin, and it sounds like it might be quite unsafe to combine with polycyclic aromatic drugs like say naphyrone, cannabinoids like AM-2201, etc.

 

[iodo]

LSD isn't the "chemical version" of mushrooms.

And your question has no definite answer; an enthusiast might extract/synth active ingredients, but whether or not they become mainstream, are stable enough to sit for a while, or even worthwhile trying, no one can say for sure until some chemist decides to attempt it.

 

[Mycophile]

Yeah, what the guy above me said.

LSD is totally unrelated to psilocybin, they aren't even in the same class of hallucinogens as LSD is a Lysgeramide and Shrooms/psilocybin are a tryptamine.

LSD and LSA (in Morning Glory Seeds and Baby Hawaiian Woordrose seeds) are related to Ergot, which is the natural plant/fungus which contains LSD.

LSD is a synthetic form of the chemical in Ergot, and synthetic Psilocybin is a synthetic form of the chemical in psilocybin Mushrooms.

 

[QUARE]

RCs market is full of GABAergic drugs from new synthetic to unscheduled pharmaceutic.

 

[Crankinit]

RCs market is full of GABAergic drugs from new synthetic to unscheduled pharmaceutic.

Most of which are mislabeled, contaminated, untested crap.

Just buy some weak (real) benzos if you want to mimic kava.

 

[Cane2theLeft]

Yeah, what the guy above me said.

LSD is totally unrelated to psilocybin, they aren't even in the same class of hallucinogens as LSD is a Lysgeramide and Shrooms/psilocybin are a tryptamine.

LSD and LSA (in Morning Glory Seeds and Baby Hawaiian Woordrose seeds) are related to Ergot, which is the natural plant/fungus which contains LSD.

LSD is a synthetic form of the chemical in Ergot, and synthetic Psilocybin is a synthetic form of the chemical in psilocybin Mushrooms.

This is all spot on except LSD and psilocybin ARE both tryptamines.

I buy pills that are kavalactone extracts - kavalactones are the active compounds. Good kava products list the kavalactone content. The pills I get contain 75mg kavalactone per pill. Because quantities and ratios of specific kavalactones can vary by plant/product, the effects vary somewhat as well. I do believe there are some good kava extract products on the market currently and as long as they are derived solely from the root, hepatotoxicity should not be a worry. The whole concern over liver damage came because (Primarily European) pharmaceutical companies upon learning of kava's effect started using parts of the plant that natives who used kava for generations would typically discard (stems, leaves, etc) because they wanted to increase profit margins. It's a shame that a good supplement is banned in countries like Germany and gratuitous warnings are required in the US because of corporate impropriety. There is still some concern over toxicity of kavalactones themselves so moderation should be applied but the long history of use without major issues should reassure to a degree. With more research, hopefully they can produce effective products that do not contain potentially toxic/carcinogenic kavalactones.

I am definitely a fan of kava and find it works well as a sleep aid that doesn't produce the morning grogginess of OTC options. Most kava available commercially is complete bullshit but some are rather good (I never buy products that don't list kavalactone content and even then, there is variability in quality by brand).

(I just read that one of the kavalactones, methysticin, can (at least theoretically) increase the toxification of benzo(a)pyrene which is found in tobacco smoke so this is something smokers should keep in mind).

 

[Mycophile]

This is all spot on except LSD and psilocybin ARE both tryptamines.

I buy pills that are kavalactone extracts - kavalactones are the active compounds. Good kava products list the kavalactone content. The pills I get contain 75mg kavalactone per pill. Because quantities and ratios of specific kavalactones can vary by plant/product, the effects vary somewhat as well. I do believe there are some good kava extract products on the market currently and as long as they are derived solely from the root, hepatotoxicity should not be a worry. The whole concern over liver damage came because (Primarily European) pharmaceutical companies upon learning of kava's effect started using parts of the plant that natives who used kava for generations would typically discard (stems, leaves, etc) because they wanted to increase profit margins. It's a shame that a good supplement is banned in countries like Germany and gratuitous warnings are required in the US because of corporate impropriety. There is still some concern over toxicity of kavalactones themselves so moderation should be applied but the long history of use without major issues should reassure to a degree. With more research, hopefully they can produce effective products that do not contain potentially toxic/carcinogenic kavalactones.

I am definitely a fan of kava and find it works well as a sleep aid that doesn't produce the morning grogginess of OTC options. Most kava available commercially is complete bullshit but some are rather good (I never buy products that don't list kavalactone content and even then, there is variability in quality by brand).

(I just read that one of the kavalactones, methysticin, can (at least theoretically) increase the toxification of benzo(a)pyrene which is found in tobacco smoke so this is something smokers should keep in mind).

Isn't LSD a lysgeramide?

Or is it a phenethylamine?

I remember someone more knowlegable than me using the latter word to describe LSD as different from Shrooms.

 

[QUARE]

I always thought LSD was neither a Tryptamine nor a Phenethylamine but an Ergoline.