Misc Why isn't 300mg of DXM doing anything?

[SpunkySkunk347]

I'm an experienced DXM user, and normally 300mg is more than enough to feel the effects.
However, I feel nothing right now, and its been almost 2 hours since I swallowed the 20 cough gels. They aren't extended release or anything like that.

Yesterday I took 100mg of diphenhydramine (benadryl), could that be whats blocking the DXM? Diphenhydramine isn't just an anti-histamine, its also an SSRI...
But I've actually done DXM in the past while on SSRIs (paxil), and the DXM still worked just fine.

Other than Diphenhydramine, the only thing I've taken today was some tylenol. The only thing I've eaten today was some doritos and I drank some coca cola.

This is bullshit, and I can't exactly go back to the store I bought them from and be like "you gave me some bunk generic cough gels, I took the whole bottle and didn't trip, I want my money back"

Edit: Going to try smoking a cigarette, since I've read before that cigarettes potentiate DXM, because cigarette smoke is a weak MAOI

 

[sekio]

1. It's working, you're just not noticing it. Tolerance, blood sugar etc will contribute to this. Also the fact you took a relatively small dose.

2. Cough gels sometimes take a bit to blow up in your stomach. Sometimes several hours.

3. Mixing reuptake inhibitors and MAOIs with DXM is dangerous (DXM is already a SNRI). Be careful.

 

[BrokedownPalace]

While diphenhydramine does have minor SSRI properties, I am pretty sure it is not the reason the DXM is not working on you, at this time..

In the 1960s, diphenhydramine was found to inhibit reuptake of the neurotransmitter serotonin. This discovery led to a search for viable antidepressants with similar structures and fewer side-effects, culminating in the invention of fluoxetine (Prozac), a selective serotonin reuptake inhibitor (SSRI).A similar search had previously led to the synthesis of the first SSRI, zimelidine, from brompheniramine, also an antihistamine.

Its half-life is only 2.4-9.3 hours, so if you had taken it yesterday, most of it would have been metabolized already, anyways. For this reason I don't believe it is effecting your DXM. In the past, I have taken diphenhydramine during a dxm trip and didn't really notice any negative/adverse effects.

I would chalk it up simply to tolerance, I highly doubt you got 'bunk' cough gels... Seriously? Tolerance is not only physical, it is also psychological, and since you claim to be an 'experienced' dxm user, it is highly likely you are simply gaining both psychological and physical tolerance to the drug. Also, since you say it has only been two hours, it is highly possible it is just taking longer to digest and start acting. You also are most likely getting de-sensitized to the drug, thus creating tolerance..

Take the experience for what its worth, and next time try a higher dose.

 

[SpunkySkunk347]

Yes I will definitely need to dose higher next time...

I can feel like, a flutter, of what is supposed to be the DXM, but theres none of that overwhelming, feel like I'm floating, tunnel vision effects...

Theres just the slightest numbness on the tip of my lips, and the slightest warmness/itchiness in my arms and scalp, and the slightest hint of light-headedness...

I think this particular brand of cough gels took a lot longer to dissolve, and a lot of it already passed through my system before the rest of it had even finished dissolving... It wasn't polistirex either, it was just some shitty generic brand I've never seen before..

I don't think I use DXM often enough to have a tolerance, I only use it several times a year. This is my first time using it in over 4-5 months.

And yeah I only took 2 drags off the cigarette before I decided it was a bad idea and put it out

 

[BrokedownPalace]

Well this isn't really OD material, it's pretty basic and I don't really see it generating a whole lot of useful information; I think you can just chalk this one up to tolerance, be it physical, or psychological.

Next time try dosing a little higher, or switching brands/type.

I'm gonna close this, but if you have any questions or anything PM me.