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Cocaine Why do some people tweak on drugs?

camaroBDJ

Bluelighter
Joined
Feb 11, 2020
Messages
99
Not sure why people can do drugs and not tweak and why some people tweaking on drugs.Not sure what causes tweaking but it is like the body is in full motion and cannot stop moving.

It seems to be people that do meth or crack. You never see some one using pain killers or heroin tweaking.

A typical tweaker.

A Girl Tweaking HARD On Meth In Oklahoma City Casino


It is like the body is in full motion and cannot stop moving.
 
Stimulants increase the behaviour of the excitatory neurotransmitter Glutamate which leads to excess activation of the NMDA and AMPA receptors. This increases the action potential rate, resulting in more positively charged Calcium Ions (CA++) flooding into the axon terminals or pre-synaptic amine neurons. When this flood occurs, nerve impulse activity increases throughout the body which can result in a temporary loss of motor function control. In minor cases it's usually limited mostly to the facial muscles, hence uncontrollable tics and grinding along with jaw muscle tension. In more severe cases, motor control can be lost throughout other parts of the body as witnessed in that video.
 
Not sure why people can do drugs and not tweak and why some people tweaking on drugs.Not sure what causes tweaking but it is like the body is in full motion and cannot stop moving.

It seems to be people that do meth or crack. You never see some one using pain killers or heroin tweaking.

A typical tweaker.

A Girl Tweaking HARD On Meth In Oklahoma City Casino


It is like the body is in full motion and cannot stop moving.

She has way to much energy and cannot direct it------This happens heavily to woman ---I don't know why?.... but she needs to be at a RAVE Festival and jumping around for hours , problem is she has to really like the MUSIC , but I guarantee nobody would really notice her there tweaking while dancing around LOL! Go to any major Club and watch all the drunks and hundreds high on something; I do "Ahhhhhh"- all the time!
 
Stimulants increase the behaviour of the excitatory neurotransmitter Glutamate which leads to excess activation of the NMDA and AMPA receptors. This increases the action potential rate, resulting in more positively charged Calcium Ions (CA++) flooding into the axon terminals or pre-synaptic amine neurons. When this flood occurs, nerve impulse activity increases throughout the body which can result in a temporary loss of motor function control. In minor cases it's usually limited mostly to the facial muscles, hence uncontrollable tics and grinding along with jaw muscle tension. In more severe cases, motor control can be lost throughout other parts of the body as witnessed in that video.
No, it's not glutamate, if you ever had a solid dissociative habit or excitotoxic stuff happening you know that. Psychostimulants cause so-called locomotoric sensitation, in animals as well as in humans. Stims aren't primarily glutamatergics; they will cause changes in its levels as it's the primary excitatory transmitter but the direct effect of stims is elevations in norepinephrine and dopamine, the latter of which even sometimes lowers glutamate (through inhibitory D1/D3 kind receptors) and out of these it's either dopamine D2 or NE which causes this effects. Ever overdosed on caffeine? Another non-glutamatergic which causes somewhat similar effects.

But it's an interesting question why some people are more sensitive to this sort of effect than others. Sometimes I kept wondering about people tweaking in the subway or whatever public place out of nervousity while others don't, maybe that's related?

Btw, that girl looks to me more like she has sort of an illness but admittedly never dealt with many tweakers in real life yet and only used meth in therapeutic dosages. I wonder more how you guys manage not to get depressive rebounds off it because of these super-long legs which avoid one recovering during night as possible with e.g. methylphenidate.
 
No, it's not glutamate, if you ever had a solid dissociative habit or excitotoxic stuff happening you know that.
I have. I've experienced severe excitotoxicity from benzo withdrawal. Resulting in uncontrollable twerking, as well as a series of seizures.

It's interesting that you say this girl looks like she has some sort of illness. Presumably you're referring to some kind of neural degenerative illness such as Parkinson's Disease or Cerebral Palsy? Because high Glutamate levels and excessive excitotoxicity are very much associated with these kind of conditions.

As for the relationship between Stimulants and Glutamate, you may be interested in this study article that discusses Caffeine's excitatory effects on the Glutamatergic system and it's inhibitory effects on the GABAergic system - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132598/

Although you're correct in stating that stimulants aren't primarily Glutamatergic. There's no denying that they still have an effect on this system and when you're dealing with a stimulant as potent as Methamphetamine, it's impact on this system is going to be far more prevalent than that of Caffeine.
 
She has way to much energy and cannot direct it------This happens heavily to woman ---I don't know why?.... but she needs to be at a RAVE Festival and jumping around for hours , problem is she has to really like the MUSIC , but I guarantee nobody would really notice her there tweaking while dancing around LOL! Go to any major Club and watch all the drunks and hundreds high on something; I do "Ahhhhhh"- all the time!
Is she overdosing on meth or crack? Or is she just super high?
 
Stimulants increase the behaviour of the excitatory neurotransmitter Glutamate which leads to excess activation of the NMDA and AMPA receptors. This increases the action potential rate, resulting in more positively charged Calcium Ions (CA++) flooding into the axon terminals or pre-synaptic amine neurons. When this flood occurs, nerve impulse activity increases throughout the body which can result in a temporary loss of motor function control. In minor cases it's usually limited mostly to the facial muscles, hence uncontrollable tics and grinding along with jaw muscle tension. In more severe cases, motor control can be lost throughout other parts of the body as witnessed in that video.

Is tics or Stereotypes related?

Stereotypes is a repetitive or ritualistic movement, posture, or utterance. Stereotypies may be simple movements such as body rocking, or complex, such as self-caressing, crossing and uncrossing of legs, and marching in place. They are found especially in people with autism spectrum disorders, but can also be found in intellectual disabilities, tardive dyskinesia and stereotypic movement disorder, yet may also be encountered in neurotypical individuals as well.


Like tics, stereotypies are patterned and periodic, and are aggravated by fatigue, stress, and anxiety. Unlike tics, stereotypies usually begin before the age of three, involve more of the body, are more rhythmic and less random, and are associated more with engrossment in another activity rather than premonitory urges. Examples of early tics are things like blinking and throat clearing, while arm flapping is a more common stereotypy. Stereotypies do not have the ever-changing, waxing and waning nature of tics, and can remain constant for years. Tics are usually suppressible for brief periods; in contrast, children rarely consciously attempt to control a stereotypy, although they can be distracted from one


  • Common stereotypies - these include behaviors that are often observed such as nail biting, thumb sucking, hair twirling, biting oneself, teeth grinding, rocking, and head banging. Typically, these type of behaviors become less frequent with age.
Complex motor stereotypies - these behaviors include arm flapping, repetitive movements with the hands
 
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Is she overdosing on meth or crack? Or is she just super high?
No she was overdosed she would sweating like a pig and dizzy and heart would be so high she would demand medical help asap! She could have used a hallucinogen with Meth and reason so tweeked out?
 
Although you're correct in stating that stimulants aren't primarily Glutamatergic. There's no denying that they still have an effect on this system and when you're dealing with a stimulant as potent as Methamphetamine, it's impact on this system is going to be far more prevalent than that of Caffeine.

Calling things glutamatergic isn't very useful. Glutamate is so fundamentally involved in neurotransmission that calling meth glutamatergic is like saying it works through ATP hydrolysis. Shit since she is moving, why not invoke acetylcholine as it is fundamentally involved in muscle contraction.

The reason meth is being described in the contexts of the dopamine and norepinephrine systems is because stimulation of vta pathways is sufficient and necessary for the effects of meth. This conveys more information than saying glutamatergic signaling is increased (which, those pathways function through release of glutamate - it is truly the ubiquitous stimulatory neurotransmitter).
 
It's interesting that you say this girl looks like she has some sort of illness. Presumably you're referring to some kind of neural degenerative illness such as Parkinson's Disease or Cerebral Palsy? Because high Glutamate levels and excessive excitotoxicity are very much associated with these kind of conditions.
I'm not sure, it was just an impression but if then I'd say tardive dyskinesia which is related to Parkinsons, yeah - but everybody gets different symptoms, it just reminded me of some of the poor souls who got intoxicated by their docs with antipsychotics which is kinda the opposite of meth but possibly because of meth being neurotoxic in high amounts, either she was using meth for too long in too high and developed a variant of TD and just dosing for feeling normal again without success and thus overdosing, or its like @hardtack said, too much energy which I can definitely emphasize to, it's bad to take high doses of stims in the wrong set.. yet to get this amount of 'tweaking' I'd need to dose high enough for to be ready for the ER and at least panicking solidly.
 
Yeah I could never understand how you can use grams within just 24h and not either freak out or become a medical emergency. I'm somebody who loved meth ... in like 25mg/d, and couldn't sleep from this amount. Never had anything like tweaking, somehow I suspect too that it's not just biological but also character related reasons. Extroverted people being more susceptible while the introverted are more prone to freaking out because of all the suppression of energy..
 
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