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Esoteric Who here has used acetylcholinesterase inhibitors?

Esperighanto

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I just wanted to ask if anybody here has ever had mystical experiences off of acetylcholinesterase inhibitors, specifically I've used sinicuichi and galantamine+CDP-Choline (I've been referring to it as GCC). Sinicuichi felt a lot more mystical and mushroom-y/ayahuasca-y in a very spiritual, natural way, eliciting very mushroom like visuals and euphoria, a deeply empathogenic emotional openness that was upbeat but somewhat neutral in a peculiar way. I could remember so many things I forgot I had even forgotten, it was very peculiar, and lasted about 4 hours after smoking 6 bowls of the shit, stems and all.

Galantamine felt more sharp, colorful, energetic, euphoric, and it reminded me much more of a highly unique variant of LSD if that makes sense. It has that sharpness of DOXs, 2C-B, and N-benzylated phenethylamines, but much like those aforementioned compounds the headspace was outweighed by the euphoric pins and needles, the code I was writing was clicking like figurative gears in a well oiled machine, I got an insane amount of work done as a software engineer at that time. I didn't expect this combo to cause a trip so I took it before work, foolishly as I now know in retrospect. The visuals at many points were akin to 25I-NBOMe, my boss' finger moving through the air as she traced the paths of database connections for a query I was writing looked like a goddamn psychedelic sparkler, and both of the AcEH inhibitors caused size warping effects visually with a huge intensity, as well as general color saturation. The closest I've ever got the body feeling with other drugs is eating a lot of 2C-B and Etizolam with ~60mg of MDA, but a little less rolly yet with that same velvet-y vibe to it.

I'm shocked that I haven't heard more people talk about experiences from these substances, ancient Media American people treated sinicuichi on par with psilocybin containing mushrooms, LSA containing seeds, and mescaline containing cacti.

The compounds in Sinicuichi are incredibly understudied, and I have no idea if any of these are safe, but between that and the galantamine paired with CDP-Choline, I'm just surprised nobody else has really gone in on these.

Edit: I cannot tell how a low dose of blue lotus and a moderate dose of b caapi tea leads to a trip either, does anybody here know about that yet? Apomorphine, nuciferine, harmine, harmaline and tetrahydroharmine seemed to be the five way chemical synergy as far as I'm aware but maybe there's more going on? Idk.
 
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I take a low dose of galantamine (2mg) daily to offset the anticholinergic side-effects of another med I take. What dosages of galantamine and CDP-choline do you use?
 
I think I took a single capsule of CDP-Choline as it was marketed for supplement use, and that day was 16mg of galantamine. I usually use 8 or 16 to potentiate lucid dreaming but I was heading into work to code so I figured it would help.
 
I just wanted to ask if anybody here has ever had mystical experiences off of acetylcholinesterase inhibitors, specifically I've used sinicuichi and galantamine+CDP-Choline (I've been referring to it as GCC). Sinicuichi felt a lot more mystical and mushroom-y/ayahuasca-y in a very spiritual, natural way, eliciting very mushroom like visuals and euphoria, a deeply empathogenic emotional openness that was upbeat but somewhat neutral in a peculiar way. I could remember so many things I forgot I had even forgotten, it was very peculiar, and lasted about 4 hours after smoking 6 bowls of the shit, stems and all.

Galantamine felt more sharp, colorful, energetic, euphoric, and it reminded me much more of a highly unique variant of LSD if that makes sense. It has that sharpness of DOXs, 2C-B, and N-benzylated phenethylamines, but much like those aforementioned compounds the headspace was outweighed by the euphoric pins and needles, the code I was writing was clicking like figurative gears in a well oiled machine, I got an insane amount of work done as a software engineer at that time. I didn't expect this combo to cause a trip so I took it before work, foolishly as I now know in retrospect. The visuals at many points were akin to 25I-NBOMe, my boss' finger moving through the air as she traced the paths of database connections for a query I was writing looked like a goddamn psychedelic sparkler, and both of the AcEH inhibitors caused size warping effects visually with a huge intensity, as well as general color saturation. The closest I've ever got the body feeling with other drugs is eating a lot of 2C-B and Etizolam with ~60mg of MDA, but a little less rolly yet with that same velvet-y vibe to it.

I'm shocked that I haven't heard more people talk about experiences from these substances, ancient Media American people treated sinicuichi on par with psilocybin containing mushrooms, LSA containing seeds, and mescaline containing cacti.

The compounds in Sinicuichi are incredibly understudied, and I have no idea if any of these are safe, but between that and the galantamine paired with CDP-Choline, I'm just surprised nobody else has really gone in on these.

Edit: I cannot tell how a low dose of blue lotus and a moderate dose of b caapi tea leads to a trip either, does anybody here know about that yet? Apomorphine, nuciferine, harmine, harmaline and tetrahydroharmine seemed to be the five way chemical synergy as far as I'm aware but maybe there's more going on? Idk.


I have been using Huperzine A regularly, almost daily, for over 5 years.
About 200ucg per day, I basically never redose.

It's just a slight cognitive boost but I hear that a large dose without a tolerance can be psychedelic/mystical.

It is also a NMDA antagonist so I think that will come into play at high dosages.
 
I have been using Huperzine A regularly, almost daily, for over 5 years.
About 200ucg per day, I basically never redose.

It's just a slight cognitive boost but I hear that a large dose without a tolerance can be psychedelic/mystical.

It is also a NMDA antagonist so I think that will come into play at high dosages.
I've taken Huperzine A up to some pretty reckless doses I don't want to mention out of the sake of harm reduction, but the feeling could be easily replicated with a fistful of galantamine tablets (25-30mg perhaps) and a bump or two of ketamine.
 
I've taken Huperzine A up to some pretty reckless doses I don't want to mention out of the sake of harm reduction, but the feeling could be easily replicated with a fistful of galantamine tablets (25-30mg perhaps) and a bump or two of ketamine.
There definitely is a potential for reaching lethal levels of acetylcholinesterase inhibition.
You would die of cardiac or respiratory arrest while your whole body cramps I guess?
 
Deliriants have a similar mechanism of action (antagonism instead of indirect agonism of acetylcholine receptors) and are notorious for their hallucinogenic activity.
...maybe there's a connection? It's a stretch... :doh:
 
There definitely is a potential for reaching lethal levels of acetylcholinesterase inhibition.
You would die of cardiac or respiratory arrest while your whole body cramps I guess?
For example, zyclon B and other nerve gases, act on the acetylcholine pathway...
for that reason, taking some strong AChe inhibitor like huperzine A can protect you somewhat against that shit as it competes with the terrible gases.
 
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