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RCs Which is the worst GABAergic sedative you have ever taken? (Benzos, Z-Drugs, ludes, Phenibut, GBL etc.)

Mana0909

Bluelighter
Joined
Dec 17, 2024
Messages
80
Location
europe
Dear Users,

For this poll, I propose that we include all substances that act on GABA, increasing its concentration in the brain. Examples include:


Benzodiazepines:
  • Diazepam (Valium)
  • Lorazepam (Temesta)
  • Alprazolam (Xanax)
  • Bromazepam (Bromazanil)
  • Tetrazepam (Musaril)
  • Chlordiazepoxid (Librium)
  • Clonazepam (Rivotril, Klonopin)
  • Flunitrazepam (Rohypnol)
  • Ethyl Loflazepate (Ronlax, Meilax, Victan)
  • Rilmazafone (Rhythmy)
  • Bretazenil (RC)
  • Clonazolam (RC)
  • or other similar substances
Z-Drugs:
  • Zopiclone
  • Pagoclone
  • Zolpidem
  • Zaleplon
  • or other similar substances
Quinazolinones (very rare):
  • Methaqualone (Quaaludes)
  • Mephenaqualone (RC-Quaaludes)
  • Afloqualone (RC-Quaaludes)
  • Ethaqualone (RC-Quaaludes)
  • Mebroqualone (RC-Quaaludes)
  • Methymethaqualone (RC-Quaaludes)
  • or other similar substances
GABA-B Agonists:
  • Phenibut
  • 4-Fluorophenibut (RC-Phenibut)
  • Tolibut (RC-Phenibut)
  • GBL
  • GHB
  • 1,4 Butanediol
  • Diethyl ether
  • or other similar substances
Barbiturates:
  • Amobarbital
  • Secobarbital
  • Thiopental
  • Pentobarbital
  • Phenobarbital
  • Barbexaclone
  • or other similar substances
We will exclude "ethanol/alcohol" from this list to focus on other substances. This is just a brief list of popular GABA-acting substances (except for the rare Quinazolinones, which are very hard to obtain).

In my opinion, the worst sedative is Bretazenil. Benzodiazepines generally do not cause euphoria like Phenibut and Mephenaqualone. They can lift your mood when you are emotionally distressed, but Bretazenil does not achieve this. It always decreases my mood and makes me feel depressed. While it has the typical tranquilizer/sedative effects, this does not benefit me if it causes depression. This is the exact opposite of its intended purpose.

My favorite substance is Mephenaqualone (RC-Quaaludes).

I am very interested in hearing about your experiences. Which GABA-acting substance do you consider the worst and the best?

Stay safe, Mana0909
 
Floribut was heinously caustic to insufflate, but I have no idea what salt form it was in. Also we should've probably just eaten it. As far as benzos go, lorazepam consistently makes me hallucinate like zolpidem and other z-drugs do. Never got my hands on barbs or quinazolinones.
 
Very interesting,

Yes, obtaining quinazolinones is almost impossible. I am fortunate to live in a country where they are available in shops and are still legal.
However, when it comes to barbiturates, we are in the same boat.

I have never managed to get my hands on an analogue, nor do I know anyone in real life who has. Back in the 1930s and especially the 1940s, there were over 100 different barbiturates on the market. They were eventually replaced by quinazolinones ("-qualone" type substances), which were much safer but had the same addiction potential: strong sedation, anxiety suppression, muscle relaxation, hypnotic effects, and strong euphoria and motivation enhancement.

In 1962, the first benzodiazepine, Chlordiazepoxide (Librium), triggered a hype. Then, in 1965, Diazepam (Valium) came out and took the world by storm.
Most barbiturates were instantly banned worldwide in 1970, and quinazolinones were totally (worldwide) banned in 1984.
Although benzodiazepines are also highly addictive and have a high dependence potential, they do not cause strong euphoria like barbiturates and quinazolinones.
Additionally, they are much safer than barbiturates.


But what I don't understand is why Lorazepam made you hallucinate. Did you take it together with something else, like cannabis, 2CB, or another psychoactive drug?

I am not quite sure, but I think you refer to "Floribut" as 4-Fluorophenibut (also called F-Phenibut). Sadly, this substance is also illegal in my country, just like the original Phenibut. Could you tell me how it compares to other GABAergic substances?

I am very interested in Phenibut and its analogues because it is my second favorite drug of all time, after Mephenaqualone/Quaaludes. Does it also cause euphoria and motivation like the original Phenibut and have those "tranquilizer" effects that I listed above (sedation, anxiety suppression, muscle relaxation, hypnotic effects)?

Stay safe, Mana0909
 
But what I don't understand is why Lorazepam made you hallucinate. Did you take it together with something else, like cannabis, 2CB, or another psychoactive drug?

I am not quite sure, but I think you refer to "Floribut" as 4-Fluorophenibut (also called F-Phenibut). Sadly, this substance is also illegal in my country, just like the original Phenibut. Could you tell me how it compares to other GABAergic substances?

I am very interested in Phenibut and its analogues because it is my second favorite drug of all time, after Mephenaqualone/Quaaludes. Does it also cause euphoria and motivation like the original Phenibut and have those "tranquilizer" effects that I listed above (sedation, anxiety suppression, muscle relaxation, hypnotic effects)?

Stay safe, Mana0909
Lorazepam makes a small percentage of the population hallucinate akin to Z-drugs, I'm not sure why. It seems to have some overlap with people who have brain damage or schizotypal issues, and I did have very noticeable brain damage around that time which manifested as schizotypal symptoms which went away as I got better. I was taking the lorazepam alongside hydromorphone daily, I was a terminally ill teenager (13-16 y/o) at this point. Mixing lorazepam with cannabis made it hit like a normal benzo, and later in life (18-19 y/o) I would find that using cannabis left me completely neurotypical for 3-4 days after use. My doctors nowadays think that I may have experienced specifically cholinergic neurodegeneration during that brain damage, and nowadays if I go more than 3-4 days without using cannabis, I still get a negative affect but I'm not seeing demons on the street corner, or sobbing over my mother's corpse for hours straight after watching her commit suicide, when really it never happened at all and was a hallucination the entire time.

By saying floribut I am referring to 4-Fluorophenibut, my apologies for the bothersome abbreviation. Tolibut is often used to refer to 4-Methylphenibut, in a similar naming scheme. It had maybe 10-20% of the euphoria of MDMA, and an oddly stimulating-while-sedative feeling. It made me want to dance and fuck, but also it had me melting into my boyfriend cuddling on the couch, completely sedentary. MDA, MDMA and low-to-moderate doses of ketamine can also have a similar effect in my opinion. You need only ~1/3 as much for a full dose relative to phenibut, and it's much more of a party drug than phenibut. Tolerance also forms slower than phenibut, but it's far less functional for daily use unless grinding your teeth with pupilary dilation oscillating on and off fits your daily life. There is certainly sedation, anxiety suppression, muscle relaxation, but it's more stimulating/empathogenic than phenibut itself.

I just want to put it out there for other readers too that mephenaqualone and methaqualone (aka Quaaludes) are not the same drug, they differ in potency by a scale of ~100x iirc and mephenaqualone can kill much easier. Please be careful with mephenaqualone. How would you compare it to methaqualone?
 
Thanks for your reply!

I'm calling Mephenaqualone, Quaaludes too, because the effects are so insanely similar. I took the OG Methaqualone 3 times in my life and I can say with not a single percent doubt that the physical and psychological effects are the same, as well as its intensity.

The only difference is that Mephenaqualone (like you've said) is way more potent, not exactly 100 times, more like 80-90 times I would say. 4mg of Mephenaqualone can be compared to 300mg of Methaqualone in my opinion. It's also very safe, meaning it's not destroying your nerves, neurons, and organs, like (sadly) almost every other quinazolinone (Methaqualone analogue).

The problem is (like I've mentioned countless times in posts) the short duration. I'm going to copy and paste my last post about that. I hope that's okay.

Mephenaqualone lasts 2-4 hours (mostly 3 hours), and this quinazolinone is considered one of the longer-acting ones.

  • Warning: Although PsychonautWiki states that it has a duration of 15-20 hours, this is not true. After 2-4 hours, the euphoria, motivation, etc., are gone, and only the typical GABAergic tranquilizer effects (sedation, anxiety suppression, muscle relaxation, hypnotic) remain. The great feeling is gone.
Methaqualone (OG) also has a main duration of 2-4 hours. It is reported to last on average 10-15 minutes longer than Mephenaqualone.

  • Warning: The same goes for Methaqualone. Although PsychonautWiki states 5-8 hours, this is incorrect. It is important to always look at the "come up and peak" phase. This applies to all quinazolinone substances.
In general, all quinazolinones that you can find have a total duration of 30 minutes to 4 hours! I think you can imagine that this can be very frustrating (at least in my opinion). Methaqualone and Mephenaqualone are even the two quinazolinones that have the longest duration with 2-4 hours. All others have an average total duration of 1-2 hours, some even only 30-60 minutes. I think that's another reason why practically no official quinazolinone medication/drug is on the market. That's truly, in my opinion, the only thing that I like more about benzodiazepines, the very long duration...such as Clonazepam or Diclazepam.

Oh yes, I can totally relate to your Phenibut experience. In my opinion, cuddling on GABAergic substances, or in general being with the person you love, is the most beautiful thing for me. I can also relate to the fact that Phenibut has a mild MDMA side to it, but without any comedown and it acts way longer. I must say that I never had grinding teeth on the standard Phenibut. I know that it can be stimulating, but this is new for me. The way you describe F-Phenibut makes me truly more and more hyped. Is it legal in your country? Like I've said, Phenibut and F-Phenibut are so hard to get now. The only thing legal is actually "Tolibut aka. 4-Methylphenibut." I couldn't find much information on that and also my vendors don't sell samples sadly, but two days ago my fiancée (in a couple of days finally husband) already texted some vendors and asked for it. If they can order a charge.

Firstly, I'm sorry for you, I mean that you were mentally ill. I truly hope that your family, friends, and boyfriend support you and you also got my support. I also combined cannabis (THC) with Lorazepam (2.5mg) and after I did that, like 30 minutes after consumption, I started to run through the forest with a big smile...I felt so free and so connected with nature. It's not the same as on acid, etc. I was just high and felt free in a way. Lorazepam is, in my opinion, a good trip killer, but nothing that I would put on my favorite list. I would give it 2.5/5 or 3/5, but in all honesty, benzodiazepines aren't really that nice for a rush. They are gold when you have heavy psychological problems, a broken heart, or other emotional scars, but for a rush? I don't know...maybe in mild doses, meaning 10mg Diazepam. The only benzo I really like in higher doses (1mg - 4mg) is Clonazepam. Yes, I know Flunitrazepam does cause euphoria, but it's also mild and they are hard to get. I think that you might have experienced paradoxical effects with Lorazepam? I mean, that's a thing that can happen with benzos, or it truly had to do with your mental state...it's hard to tell and I won't play Internet Psychologist, because I hate those kinds of people, because I find it very disrespectful to judge someone online and give them a diagnosis. I really respect you and your past experiences and wish you much love and power!

But yeah, that's why I prefer Phenibut much more, because it causes euphoria and enhances your motivation. If you want, I can also tell you the difference, aka make a comparison between Methaqualone/Mephenaqualone and Phenibut.

Stay Safe and take care, Mana0909
 
With mephenaqualone only being available in Germany right now, I'm not the most concerned about misnomer issues, but here in the US we tend to have huge issues over mistaken drug identity. Nowadays it's mostly fentanyl/nitazene related, but also the amount of people turned away from psychedelics because their first experience was with a very challenging substance like 25I-NBOMe which was sold to them as LSD, and they never tested it and until I pointed out that the experience doesn't align with LSD at all, they just continued thinking that 25I-NBOMe in dangerously high doses is what LSD feels like. Those sorts of misnomer issues seem to be much worse here in the US than elsewhere, and if quinazolinones were on the street here I can promise you we'd have a fentanyl-like crisis where some highly unethical street dealer does a poor job of cutting mephenaqualone down in potency to sell as methaqualone, somebody dies from a 95mg dose of mephenaqualone due to a hotspot, and all of a sudden we've got a fresh hell as far as our local drug hysterias go. I'm assuming you're in Germany given the drugs you've mentioned being able to access, and German culture overall has a much more level head on this shit as far as street dealers go when compared to Americans.

When I'm writing anything on BL, I always think "What will a 16 year old 10 years from now interpret from this before doing something stupid", because I've been that 16 year old perusing drug forums before randomly eyeballing mystery opioids/benzos under my tongue to see what they did.

If you want something that people at least claim feels similar to methaqualone, but can last much longer, mixing carisoprodol with a benzodiazepine can dramatically amplify potency as well as duration. I won't say it's the safest thing to do mixing downers and all, but I've found that carisoprodol + benzos blows benzos on their own clean out of the water. I'm in the northeastern US where people really only consume opioids, methamphetamine, psilocybin containing mushrooms, and cannabis regularly. I'm actually in a "cannabis capitol", the majority of the American east coast's cannabis is grown in the state I grew up in and am living in for the next couple of weeks (Maine). Also, tolibut isn't something I've used, but a friend of mine who's quite into floribut tried it and was unimpressed. This person is a helpless addict who chases hedonistic pleasure wherever they go and needs to remain virtually totally sober outside of their cannabis and prescribed amphetamine nowadays, but they didn't find tolibut quite as hedonistically satisfying as floribut if I recall correctly.

Floribut, phenibut, tolibut, etc. are all completely uncontrolled in the US as far as I'm aware. I can buy them online alongside tianeptine, DMAA, propylhexedrine, but most people would rather go for street drugs (stepped on cocaine, mystery dope referred to as "down", cartel synthesized super clean methamphetamine usually just referred to as "up", and spice). In this state in fact, you can't really find any empathogens at all outside of the nomadic dealers that follow jam bands who come through once in a while, and the only psychedelic available is psilocybin containing fungi, which are mass produced here by the same people who produce all that cannabis I mentioned earlier. People in Maine have a "cannabis culture" the same way that places like Ireland have an "alcohol culture", so often the first thing I hear after walking into somebody's house is "You tryna smoke?". At one point I was vaporizing (with nearly 0% loss) 2g of THC a day, sometimes rosin, sometimes pure white THCa diamonds. An ounce of either would set you back $150-$300, and I was killing an ounce on my own in two weeks, but was making money at that time to where it didn't matter at all. We also lacked restrictrions on growing for a while, so while doing all of this I was operating a 28 plant grow in a spare bedroom of my apartment. Once psycehdelics were legalized in my city though I began pivoting towards personal use levels of DMT, psilocin and mescaline extraction predominantly, as cannabis was just more cost efficient to buy rather than to grow.

Thank you for the kind words and all, nowadays the mental illness is pretty much completely wrapped up, the brain damage was recovered by somewhat unhinged use of serotonergic psychedelics it seems. They release two hormones (NGF, Nerve Growth Factor and BDNF, Brain-Derived Neurotrophic Factor) which contribute to the (re)generation of neurons and an increase in neurons' dendritic complexity, and according to my neurologist, my brain scans went from being "unintelligible" to looking "perfectly normal". I found this interesting too given how often I've used things such as 3-MeO-PCP, 3-HO-PCP, 3-HO-PCE, Ketamine, MDA, MDMA, 6-APB, etc. in the past. I was definitely expecting more of an issue than was found, but it seems like being primarily focused on cannabis and serotonergic psychedelics pays off in the long run. At one point I took ~600x the standard dose of LSD found on tabs here in the US (~20mg, not ug but mg at once), and that also seems to have directly correlated to the recovery. I have no evidence other than my own lived experience to back this up, but it was pretty shocking to hear from the neurologist as to how my recovery had gone so well despite seemingly being so reckless with things. Outside of some very run of the mill depression, I function completely normally nowadays as long as I can get a cannabinoid of any sort (THC, [THC/HHC]-[O/B/H/P/V], street spice, etc) into my system every few days.

Your lorazepam experience is interesting, 2.5mg is a very low dose, but I'm glad you kept it low. I was taking 6mg up to 4 times a day when I was terminal as a teenager, but quickly found that the aftereffects made me feel as if I'd given myself a mental disability so I would go through phases of playing with it, then dropping it without a taper, and I learned some very hard lessons about the seizures they can induce. I could never notice less than 4mg of lorazepam, even as a child, but I was also ~100kg at that age, like I still am today. My boyfriend (soon fiancee) however is ~68kg and notices little microdoses of benzos that I would completely overlook though, so I suppose it just has to do with subjective perspective and neurotypology and all of that jazz. When I was using floribut, I was actively in love with a few people and was part of a 7 person polycule that all lived together, it was quite a peculiar period in my young adult life. I was 22-23 years old, and we would oscillate group cuddling and group sex while using it quite often because it produced MDMA-like effects without inducing erectile dysfunction in those who had that issue.

Lorazepam is certainly unimpressive, if I'm trying to GABAergically trip, I'd rather just use zolpidem. I'd give Lorazepam maybe a 2/5 as far as how fun it could be, compared to alprazolam, diazepam, etizolam, bromonordiazepam, etc.

I would love to read your comparison between methaqualone/mephenaqualone and phenibut if you'd like to share!

Stay safe and take care as well.
 
Worst - Phenibut by far. Worst effect, worst side effects, worst withdrawal relative to it's effect. One of the few drugs that I actually hate and will never touch again even if it were free.

Best - more difficult for me to answer, but I guess alprazolam.
 
I've taken:

Diazepam, Lorazepam, Alprazolam, Clonazepam, & Chlordiazepoxid
These are all good for detoxing from alcohol and for short-term anxiety relief. All increased my anxiety when used long-term.

Methaqualone ( Rorer 714, Lemmon 714)
Overrated. Yeah, you'll probably have fun but you won't remember it. Drink alcohol too and you'll probably wake up with unexplained injuries. I always called Quaaludes "Stumble Biscuits," owing to their effects and the size of the tablets-- about as big as TUMS.

Butabarbitol, Phenobarbital, Pentobarbital, & Secobarbital.
Scary. They can cause euphoria but the dosage required is dangerously close to unconsciousness or even  coma, which I experienced twice. Time-travel drugs: one minute you're starting to feel great and the next thing you know it's a week later and you're on a ventilator in ICU. My go-to drugs for suicide. Great way to go!

GHB.
Only took it 3 or 4 times. Once with alcohol-- that's a blackout night. Other times were just relaxing & pleasant, nothing spectacular.


I will probably avoid  all of these drugs in the future until I'm ready to die. As I said before, barbs are a great way to go. Relaxed, happy, warm & fuzzy, and then nothing. You're out.
It's like flipping a switch.
 
Thank you for your loving and very detailed reply!

It's truly insane what kind of experiences you had and how much you overdosed. Back when I was 19 or 20 (not quite sure right now), I took:

  • 2x Blue Punisher - they contained 294.1mg MDMA each (my fiancé/husband always bought test kits because he wants to be sure that I am safe. He also takes them, but I know he mainly does this to keep me safe). This means I had 588.2mg MDMA in my blood!
  • 2x Blue Punisher (again) - yes, exactly...two days after this insane OD, I did it again. The problem was that back then, it was very difficult for me to get drugs that I really wanted (GABAergics, opioids, etc.). Only weed was available and (sorry) I hate it. It always makes me feel weird. The only thing I like is the increased music appreciation, but I must say that 450mg of Pregabalin has some similarities with THC, but the trip is 100 times better.
Back to the story, so I now took almost 1.2g of MDMA in just 3 days and then on the next evening (meaning the 4th day), it started to happen: because of my insane serotonin loss, I had the worst anxiety you can imagine. I screamed and cried so much...my depression was out of this world. You need to know that I was also alcohol addicted at this time for 4 months and I only got 4 hours of bad sleep.

My darling fiancé instantly called through his plug's contact list and only one had benzodiazepines. I also remember 100% that those were the original Diazepam/Valium, meaning those blue pills from "Hoffman La Roche." The problem was that this plug was a creep. He tried many times to hit on me, even though I slapped him multiple times and my fiancé completely beat him up. Yes, we truly didn't have any luck, but this creepy loser was our only option! This loser said he would give them for free (those had 10mg and 30 tablets) if I would go on a date with him...yes, he tried to abuse the situation, but I instantly screamed "fuck you, never." He then wanted 300€ for this package, yes...300€...but my fiancé instantly agreed and drove over to him (I was also in the car because I couldn't be without him). In 10 minutes, we were there, and he paid this creepy asshole the 300€. After my fiancé gave me two pills (20mg), I slowly calmed down and got clingy. We drove back home and cuddled...I'm so thankful to have such a perfect fiancé, otherwise, I don't know what would have happened.

I have respect for all the substances you took. Ketamine was never interesting for me. I don't really get it; it sounds like a bad version of Pregabalin + Quaaludes for me (except the K-hole, of course, I mean in normal doses). I also don't like psychedelic drugs in general. Yes, a mild dose of MDMA (80mg) or 2CB (8mg-9mg) is smooth and enjoyable, but everything else is just...not enjoyable in my opinion. I prefer drugs that only have a couple of effects but all of them are positive instead of drugs that have insanely many mixed effects. But PCP and its derivatives are more interesting in my opinion. Could you describe how those felt? I mean, you took many analogues, but I guess they are similar in many ways...I know that it was very popular in poor areas of America because it was so cheap. I would love it if you could describe it.

I know that many analogues are being sold as Quaaludes, but hearing that "Mephenaqualone" is one of them? You have to know that there are way cheaper alternatives than Mephenaqualone. Also, in the RC shops, it's quite expensive compared to others. There are way cheaper quinazolinones out there, but thanks for telling me. Could you tell me when this incident happened? Because the first posts with Mephenaqualone happened around 2023 and like you've said, it's a German RC, but wtf 95mg of Mephenaqualone??!??! Just so you know, a normal dose is considered 1.5mg - 2.5mg and a strong one is 3mg...the maximum a user should take per day is 6mg split into 3x2mg doses. You have to take RC-Quaaludes 3 times because of their short duration. Could you tell me if there was fentanyl or alcohol included? Because yes, solo 95mg Mephenaqualone is insane, that's almost a 25-times overdose, but still, it's insanely rare that someone dies from this when taken solo. You can easily die from 600mg Methaqualone (8mg Mephenaqualone) when you take it together with alcohol!

Important: All quinazolinones are insanely, and I mean insanely, deadly when combined with alcohol. Even one beer is enough to kill you! Way more dangerous than benzodiazepines + alcohol!

Alright, the difference between Mephenaqualone/Methaqualone (Quaaludes) and Phenibut is that Quaaludes have a stronger hypnotic effect and muscle relaxation. When you lie in bed on a moderate dose of Quaaludes, it feels like heaven, like on opioids...everything feels so light, your body, the blanket...so comfy, especially when you cuddle with someone. This effect is also definitely solid on Phenibut, stronger than Chlordiazepoxide (Librium) but weaker than Quaaludes. The euphoria is mild-moderate with Phenibut. In my opinion, the euphoria is great with both substances, but it's just different, and I tend to say that Quaaludes are stronger both cognitively and physically. The anxiety suppression is strong with Phenibut, way more when compared to alcohol or low-medium doses of some low-potency benzodiazepines, but it's also weaker overall than Quaaludes, but the difference isn't that big. The sedation is moderate with Phenibut and strong with Quaaludes, but here we have the smallest gap.

Overall, I would say that Phenibut is a light version of quinazolinones. Also, Phenibut is way cheaper and way easier to get. Yes, the onset takes way longer, but the duration of action is 3-6 times longer. In my opinion, Phenibut is a 4/5 and even slightly better than my two favorite benzos, Clonazepam and Flunitrazepam, but still not comparable with quinazolinones.

Stay Safe, Mana0909
 
Worst - Phenibut by far. Worst effect, worst side effects, worst withdrawal relative to it's effect. One of the few drugs that I actually hate and will never touch again even if it were free.

Best - more difficult for me to answer, but I guess alprazolam.
We both have the exact opposite opinion, because I would say that alprazolam is one of the worst benzos.
It suppresses your anxiety so much that you're absolutely emotionless, and this causes dysphoria in many cases.

Better options are:
  • Temazepam
  • Tetrazepam
  • Clonazepam
  • Flunitrazepam
Those are not as good as the four above, but also solid:
  • Oxazepam
  • Diazepam
  • Chlordiazepoxid
  • Rilmazafone
And those are as bad as alprazolam:
  • Lorazepam (that's a tiny bit better than Alprazolam)
  • Bretazenil (that's on the same level as alprazolam)
Especially the hypnotically acting benzos are the ones that cause the most euphoria.

But yeah, overall Mephenaqualone/Methaqualone (Quaaludes) are the best sedatives and GABAergics, and after that comes Phenibut in my opinion.
It's interesting to see how different opinions can be on things, especially when seeing that it's truly the complete opposite.

Stay safe and wish you a great Christmas Eve, Mana0909
 
GHB.
Only took it 3 or 4 times. Once with alcohol-- that's a blackout night. Other times were just relaxing & pleasant, nothing spectacular.
In college I ran into GHB with no idea as to what it was in the first place, as I went to college in South Florida but I'm from Maine. I was already using the combination of kratom, kava, cannabis, alcohol, amphetamine (redirected Adderall or eurospeed typically), and street benzos at the time when I'd be out partying but GHB was some new thing I just decided to add to the mix. I cannot overstate how goddamn lucky I am to have survived that period of my life. Any two way mix of GABA agents is already risky, but drinking, using benzos, and using GHB at the same time about 2/7 days (on my days off) led to some blacking out that eventually stopped after maybe a month or so of doing this buffoonery. I want to stress again that I likely only survived this due to bodyweight, metabolic quirks, and missing the majority of my GI tract in the first place due to past surgeries.

Nowadays as a more grown and knowledgeable adult I've used GHB here and there and find it to be everything alcohol wishes it was and even more, it's so wild how subjectively variant these drugs can be. I don't think I've drank since rediscovering GHB post-college and going "Wow, this is what alcohol wishes it was!".
Worst - Phenibut by far. Worst effect, worst side effects, worst withdrawal relative to it's effect. One of the few drugs that I actually hate and will never touch again even if it were free.

Best - more difficult for me to answer, but I guess alprazolam.
I've seen people talk about Phenibut withdrawals online but have never experienced any psychological form of withdrawal I could notice, only a couple run-ins with cold turkey dropping lorazepam that led to seizures and taught young me a lesson about how to taper correctly. I've never seen anybody describe in depth what the WD is like from phenibut, would you mind articulating upon it?
if I would go on a date with him...yes, he tried to abuse the situation
Where I'm from (and also where I'm moving to) this has led to many people going missing, but I suppose the US and Germany have very different access to guns. I'm shocked your boyfriend didn't just rob him with a knife out to be honest, what's the dealer going to do, go to the cops and say "This guy stole my illlicit substances!"
95mg of Mephenaqualone??!??!
I brought this up as a hypothetical, not a literal situation that has occurred. A big reason that fentanyl is an issue here though, in a non-hypothetical manner is that people think shaking the baggie with a bunch of caffeine powder is adeqaute to cut it, not realizing that pharmaceutical companies have been trying to figure out "perfect homogenization" since the late 1800's, and still haven't got there. Most prescribed drugs in the US have an acceptable margin of error for dose between 10-30% depending on the drug, which is much higher than other nations, but it's also because of how hard it is to homogenize certain things. If mephenaqualone hit the streets right now in the US, I absolutely promise you that any of a variety of dirtbag street dealers I know would put 30mg of mephenaqualone in a baggie with 3 grams of inositol, shake it vigorously for a few minutes and then sell it to any random person as "a hundred doses of qualuudes". Intentional misreprensetation is kind of the name of the game for many American dealers, especially because overdoses tend to attract clientele from other dealers. I can't speak much on it, but I was around a ton of drug trafficking in my youth due to some social associations, and every time a client would OD, we'd find random people who were visibly opioid addicts knocking on the door trying to get some of that, because they wanted the strongest dope they could possibly find.
Overall, I would say that Phenibut is a light version of quinazolinones. Also, Phenibut is way cheaper and way easier to get. Yes, the onset takes way longer, but the duration of action is 3-6 times longer.
This makes me feel like for practical/functional applications, phenibut certainly comes out on top.

@Mana0909 Would you mind giving a brief rundown of how you'd compare alprazolam, clonazepam, diazepam or lorazepam to any of the other benzos you'd mentioned? I'm especially interested in temazepam, tetrazepam, and oxazepam as they're quite hard to come by in the US and they seem worthwhile. Rilmazofone and chlordiazepoxide seem interesting too, but rilmazofone seems kind of "hit or miss" for most people, and chlordiazepoxide's insane duration seems like it would be neat for a little bit but get quite boring after a few days, doesn't it allegedly last for numerous days?

Happy holidays btw!!!
 
'Worst' is a term open to interpretation. If baclofen is considered to be 'GABAgenic;, it's certainly the most toxic of the class I have ever encountered. It's the only one that made me feel poisoned.

But dimethaqualone (methylmethaqualone)* while highly euphoric (especially when smoked) has the unfortunate side-effect of significantly lowering seizure threshold and possibly being a convulsant at higher doses. Now I knew this and so was careful NOT to redose, but you can't tell people and a couple of people I know insisted on finding out the hard wat.

Barbiturates and nitrobenzodiazepines have the unfortunate side-effects of producing emotional lability and profound amnesia. Again, knowing that I decided that less was more but I don't want to be anywhere near people who either don't know or don't care. Either way, aggression, violence and bizarre actions are not rare. Some people are fine, some people become dangerous.

Overall, over the decades I've come across hundreds of sedative/hypnotics that act on the GABA receptors in one manner or another. My conclusion is that most of them should really be considered DLRs as all of them are dependence forming, many have narrow TIs and all seem capable of producing a dizzying array of psychiatric side-effects.

I appreciated Heminevrin (clomethiazole) since oddly, it's technically legal in the UK but even then, it was only used to enable alcohol ceccession.

BTW until the late 1990s chlormezanone was still available as a prescription medicine in the UK. It was withdrawn due to a rare but serious side-effect. I note it still appears uncontrolled and indeed is still used medically in some nations. While I have never sampled it, I am aware that it has a small following in the UK. Apparently certain polydrug users discovered that it forms an essential part of some obscure cocktail. You know the kind of thing, those with silly names such as 'windowlicker' or 'rusty penguin' or some such. To a certain extent I think it's a UK thing. But even now I know someone who absolutely swears that 'Peach Melba' (Palfium + Ritalin) is the greatest thing INCLUDING sliced bread...

*I looked into this and it appears that whatever the para (4) substitution of the pendant aromatic of this class the resulting compounds are one hand are significantly more potent than their parent, on the other they uniformly seem to produce seizures. I smoked 100mg, got a HUGE rush that knocked me over and decided that it was time to stop.
 
I've taken:

Diazepam, Lorazepam, Alprazolam, Clonazepam, & Chlordiazepoxid
These are all good for detoxing from alcohol and for short-term anxiety relief. All increased my anxiety when used long-term.

Methaqualone ( Rorer 714, Lemmon 714)
Overrated. Yeah, you'll probably have fun but you won't remember it. Drink alcohol too and you'll probably wake up with unexplained injuries. I always called Quaaludes "Stumble Biscuits," owing to their effects and the size of the tablets-- about as big as TUMS.

Butabarbitol, Phenobarbital, Pentobarbital, & Secobarbital.
Scary. They can cause euphoria but the dosage required is dangerously close to unconsciousness or even  coma, which I experienced twice. Time-travel drugs: one minute you're starting to feel great and the next thing you know it's a week later and you're on a ventilator in ICU. My go-to drugs for suicide. Great way to go!

GHB.
Only took it 3 or 4 times. Once with alcohol-- that's a blackout night. Other times were just relaxing & pleasant, nothing spectacular.


I will probably avoid  all of these drugs in the future until I'm ready to die. As I said before, barbs are a great way to go. Relaxed, happy, warm & fuzzy, and then nothing. You're out.
It's like flipping a switch.
Wait, you really got barbiturates?
  • Did you order them online from a vendor or a marketplace, or did you get them from a local plug?
  • How expensive are they, per pill on average?
Sorry, but I'm very interested in this. These are the only drugs (at least for myself and my husband) that are even harder to get than quinazolinones.

I would never touch GHB, GBL, 1,4 Butanediol, etc. It's way too dangerous, and I'm too afraid to do that. I'm very, very happy with my current bottles...I'm so happy that I got Mephenaqualone (RC-Quaaludes), and in a couple of days, I get an extra 40-50 pellets of 4mg on top of what I already have left.

Benzo + alcohol, no. GABAergics + alcohol is something that I have never done and will never do. With (RC)-Quaaludes Meth/Mephenaqualone, it's so easy to die with this combination, but I won't judge.

It's good that you will avoid all these drugs. I'm very happy that you're strong enough to control yourself!

Stay safe, Mana0909
 
Wait, you really got barbiturates?
  • Did you order them online from a vendor or a marketplace, or did you get them from a local plug?
  • How expensive are they, per pill on average?
Sorry, but I'm very interested in this. These are the only drugs (at least for myself and my husband) that are even harder to get than quinazolinones.

I would never touch GHB, GBL, 1,4 Butanediol, etc. It's way too dangerous, and I'm too afraid to do that. I'm very, very happy with my current bottles...I'm so happy that I got Mephenaqualone (RC-Quaaludes), and in a couple of days, I get an extra 40-50 pellets of 4mg on top of what I already have left.

Benzo + alcohol, no. GABAergics + alcohol is something that I have never done and will never do. With (RC)-Quaaludes Meth/Mephenaqualone, it's so easy to die with this combination, but I won't judge.

It's good that you will avoid all these drugs. I'm very happy that you're strong enough to control yourself!

Stay safe, Mana0909

I forgot GHB. That also made me feel poisoned. For the life of me I do not know why it appears so popular.

I'm also somewhat surprised that nobody has looked into other compounds that act on the GHB receptor (apparently there is one). HOCPCA may or may not be of interest. But it's got the highest GHB receptor affinity of a series that was produced to derive a QSAR. Maybe chiral resolution is required and that said resolution doesn't lend itself to scaling....
 
@3DQSAR I would love to hear you go off some time (perhaps in another thread as to keep this one on topic) about obscure GABAergics you've used, clomethizaole for example I find fascinating, and have never heard of outside of the UK as far as I'm aware. I'm also curious as to what DLR stands for as an abbreviation. Many of those other GHB receptor agonists are super dangerous convulsants, trans-4-hydroxycrotonic acid I believe was one that nearly killed a chemist friend of mine if I'm recalling correctly.

@Mana0909 Barbs pop up in the US, India and Germany in my experience, though almost never in commercial contexts, just "yeah I know a chemist who whipped up x, y or z". I've encountered barbs on marketplaces in the past as well (but not in the last year or two for some reason). Without diving too far into the chemistry of it, they're considered kind of childishly simply to synthesize, even the precursors are super simple to whip up for any serious chemist, but barbs are universally disliked from my in-person peers here in the US, as well as a few chemists I correspond with.

Edit: @Mana0909, for future reference, the use of benzos and other GABA agents like alcohol as a tripkiller/rollkiller can be applied, but actual serotonin antagonists like antipsychotics work dramatically better in my experience guiding psychedelic sessions for others. Ziprasidone is something easy to come across here in the USA (Seroquel too) which have those effects. I'm sure there's similar you could find in Germany.
 
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@3DQSAR I would love to hear you go off some time (perhaps in another thread as to keep this one on topic) about obscure GABAergics you've used, clomethizaole for example I find fascinating, and have never heard of outside of the UK as far as I'm aware. I'm also curious as to what DLR stands for as an abbreviation. Many of those other GHB receptor agonists are super dangerous convulsants, trans-4-hydroxycrotonic acid I believe was one that nearly killed a chemist friend of mine if I'm recalling correctly.

Funny you should say that. I'm just about to start a thread on HOCPCA. I'm more than happy to send you all my references on chlormezanone. It's a really odd one.
 
Wait, you really got barbiturates?
  • Did you order them online from a vendor or a marketplace, or did you get them from a local plug?
  • How expensive are they, per pill on average?
The phenobarbital & secobarbital were both many years ago. Pheno was from a guy who had a script for his epilepsy. Seco was from my grandmother who had a script for sleep.
Neither was particularly powerful but I don't remember the mg per pill.

The butabarbitol was in an elixir, also many years ago. I found several bottles of it in a vacated dentist's office that I was cleaning out for a job. I was actually looking for glassware, syringes, and hemostats, but found none of that. The elixir was an unexpected treasure. Had some fun with it but I kept blacking out on it, so I ended up giving most of it away.

The pentobarbital is what nearly killed me, appropriately enough. It is the drug of choice for animal euthanasia and I was stealing it from the animal shelter where I worked. The brand name is Fatal Plus, which amuses me. Like, plus what? It makes you extra dead?

So I don't know anything about prices or how to get barbs. Frankly, I'd advise against them anyway. Like I said before-- there's a very thin line between feeling good and being in a coma/dead.
 
In college I ran into GHB with no idea as to what it was in the first place, as I went to college in South Florida but I'm from Maine. I was already using the combination of kratom, kava, cannabis, alcohol, amphetamine (redirected Adderall or eurospeed typically), and street benzos at the time when I'd be out partying but GHB was some new thing I just decided to add to the mix. I cannot overstate how goddamn lucky I am to have survived that period of my life. Any two way mix of GABA agents is already risky, but drinking, using benzos, and using GHB at the same time about 2/7 days (on my days off) led to some blacking out that eventually stopped after maybe a month or so of doing this buffoonery. I want to stress again that I likely only survived this due to bodyweight, metabolic quirks, and missing the majority of my GI tract in the first place due to past surgeries.

Nowadays as a more grown and knowledgeable adult I've used GHB here and there and find it to be everything alcohol wishes it was and even more, it's so wild how subjectively variant these drugs can be. I don't think I've drank since rediscovering GHB post-college and going "Wow, this is what alcohol wishes it was!".

I've seen people talk about Phenibut withdrawals online but have never experienced any psychological form of withdrawal I could notice, only a couple run-ins with cold turkey dropping lorazepam that led to seizures and taught young me a lesson about how to taper correctly. I've never seen anybody describe in depth what the WD is like from phenibut, would you mind articulating upon it?

Where I'm from (and also where I'm moving to) this has led to many people going missing, but I suppose the US and Germany have very different access to guns. I'm shocked your boyfriend didn't just rob him with a knife out to be honest, what's the dealer going to do, go to the cops and say "This guy stole my illlicit substances!"

I brought this up as a hypothetical, not a literal situation that has occurred. A big reason that fentanyl is an issue here though, in a non-hypothetical manner is that people think shaking the baggie with a bunch of caffeine powder is adeqaute to cut it, not realizing that pharmaceutical companies have been trying to figure out "perfect homogenization" since the late 1800's, and still haven't got there. Most prescribed drugs in the US have an acceptable margin of error for dose between 10-30% depending on the drug, which is much higher than other nations, but it's also because of how hard it is to homogenize certain things. If mephenaqualone hit the streets right now in the US, I absolutely promise you that any of a variety of dirtbag street dealers I know would put 30mg of mephenaqualone in a baggie with 3 grams of inositol, shake it vigorously for a few minutes and then sell it to any random person as "a hundred doses of qualuudes". Intentional misreprensetation is kind of the name of the game for many American dealers, especially because overdoses tend to attract clientele from other dealers. I can't speak much on it, but I was around a ton of drug trafficking in my youth due to some social associations, and every time a client would OD, we'd find random people who were visibly opioid addicts knocking on the door trying to get some of that, because they wanted the strongest dope they could possibly find.

This makes me feel like for practical/functional applications, phenibut certainly comes out on top.

@Mana0909 Would you mind giving a brief rundown of how you'd compare alprazolam, clonazepam, diazepam or lorazepam to any of the other benzos you'd mentioned? I'm especially interested in temazepam, tetrazepam, and oxazepam as they're quite hard to come by in the US and they seem worthwhile. Rilmazofone and chlordiazepoxide seem interesting too, but rilmazofone seems kind of "hit or miss" for most people, and chlordiazepoxide's insane duration seems like it would be neat for a little bit but get quite boring after a few days, doesn't it allegedly last for numerous days?

Happy holidays btw!!!
Yes, of course, and thank you so much for your detailed reply. I'm truly happy to communicate with you.

Yes, I understand what you mean. My fiancé also said, "When I could, I would torture this asshole in the worst possible way." Here in Europe (Germany), weapons aren't allowed, and I would also state that it's way more chill compared to the U.S., but that's only what I have seen and read. I'm not an expert by any means.

Yes, of course, I can give you a brief rundown of those benzodiazepines:

Chlordiazepoxide:
One of the first benzodiazepines ever developed, Chlordiazepoxide (Librium) is primarily used for anxiety, alcohol withdrawal, and preoperative anxiety. It has a long duration of action, typically lasting 12-24 hours. Chlordiazepoxide is known for its calming effects without causing significant sedation or euphoria. It is less potent than many other benzodiazepines, making it a safer option for long-term use. Its ability to reduce anxiety and prevent seizures during alcohol withdrawal makes it a valuable medication in medical settings.

Alprazolam: The strongest benzodiazepine for anxiety and panic attacks, truly kills all of your emotions inside and makes you a total emotionless robot. Like on any benzodiazepine, you can blackout very easily, especially from this benzo. It's also the one that causes the least euphoria and has the highest potential for dysphoric and depressive effects on the user. The next thing why this benzo is the worst is its short duration. You can calculate 3-4 hours when you take a normal dose. Then you are already normal again. The reason this benzodiazepine is so hyped is mainly because of its name "Xanax." It starts with an "X," it reads the same backward, and it also came out when benzodiazepines were still seen as the holy grail, pills that can fix all problems without any side effects. Marketing was the last thing, but I can't tell you much there because this only happened in the U.S.

Lorazepam: It has many effects that Alprazolam has, but with the difference that it doesn't cause as much dysphoria as Alprazolam. It's often used in hospitals, and doctors prescribe it more often than Alprazolam. It counts as a middle long-lasting benzodiazepine, and its main effect lasts 4-8 hours, and after 16 hours, the effect should be fully gone. It's the second strongest benzodiazepine for anxiety and panic attacks after Alprazolam, and although it's not something special, it's way safer and more comfortable than Alprazolam.

Clonazepam: The strongest benzodiazepine for seizures and one of the most loved benzodiazepines. From all benzodiazepines, this benzo has the least emotional suppression, or one of the lowest. It has the special function that it can cause mild euphoria when taken in a depressed, anxious, or emotionally broken state. The sedation is also one of the strongest you can find, and it also doesn't really make you tired. It's also perfect because it's very long-acting. The main duration goes between 8-12 hours, and you can still feel it after 48 hours!

Temazepam: After Clonazepam, the strongest benzodiazepine for seizures and also considered the benzo with one of the strongest euphoria. Like Clonazepam, it's extremely sedating and lets you feel very light. Because of the mild-moderate euphoria, it doesn't make you an emotionless robot, and on top of that, it's also the benzodiazepine that causes the strongest muscle relaxation. This means that it can help against chronic pain and increase the effect of painkillers such as ASS, Pamol, Naproxen, as well as opioids like Tramadol. The addiction potential is especially high here, same as Clonazepam, because of its high affinity for seizure reduction and muscle relaxation, meaning a withdrawal could cause heavy muscle spasms and deadly cramps.

Tetrazepam: Known for its strong muscle relaxant properties, Tetrazepam is often used to treat muscle spasms and related conditions. It has a moderate duration of action, typically lasting 6-8 hours. While it provides significant relief from muscle tension, it can also cause sedation and mild euphoria. However, its use has been limited due to concerns about severe allergic reactions.

Diazepam: One of the most well-known benzodiazepines, Diazepam (Valium) is highly effective for anxiety, muscle spasms, and seizures. It has a long duration of action, lasting 12-24 hours, making it suitable for sustained relief. Diazepam is less likely to cause severe emotional suppression compared to Alprazolam, and it provides a calming effect without making the user completely emotionless. It is often used in medical settings for its versatility and effectiveness.

Oxazepam: A short to intermediate-acting benzodiazepine, Oxazepam is primarily used for anxiety and alcohol withdrawal symptoms. It has a duration of action of 6-12 hours. Oxazepam is known for its relatively mild sedative effects and lower potential for abuse compared to other benzodiazepines. It is often preferred for its safety profile and effectiveness in managing anxiety without causing significant euphoria or emotional blunting.

Rilmazafone: A lesser-known benzodiazepine, Rilmazafone is used primarily in Japan for its hypnotic and anxiolytic effects. It has a short duration of action, typically lasting 4-6 hours. Rilmazafone is unique in that it is a prodrug, meaning it is metabolized into its active form in the body. It provides mild sedation and anxiety relief, making it suitable for short-term use in treating insomnia and anxiety. The active substance is named Rilmazolam

Bretazenil: An atypical benzodiazepine, Bretazenil is known for its partial agonist properties at the GABA-A receptor. It has a moderate duration of action, lasting 6-12 hours. Bretazenil is less likely to cause severe sedation and emotional suppression compared to full agonist benzodiazepines like Alprazolam. However, it is also less effective in treating severe anxiety and panic attacks. It is often considered a safer alternative with a lower potential for abuse and dependence. My least favorite together with Alprazolam


Oooooofff...this took a while, as you can see. Since you sent that message, I was typing and typing.
My favorite benzos from this list are:

  • Clonazepam
  • Temazepam
  • Tetrazepam
You're welcome, by the way, and I also wish you a beautiful Christmas Eve!

Stay safe, Mana0909
 
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@Mana0909 That's a beautifully detailed response, I've got some IRL obligations I need to head out for but I'll respond to this in more detail when I return. Your descriptions of chlordiazepoxide, but especially of temazepam make me want to give them a shot. At some point I'm sure I'll stumble across some temazepam, it sounds heavenly. Your description of it reminds me heavily of etizolam, even deschloroetizolam sounds somewhat similar in my opinion. Have you ever used a thienodiazepine/thienotriazolodiazepine like those? They replace a benzene ring in the structure with a thiophene ring and it leads to higher euphoria in most cases, while maintaining a long duration and high potency.

I'm also shocked at how high of a dose of tetrazepam is necessary for it to work. Funny enough, researching it after you mentioned it got me a little bit concerned. Recently there's been a supply of bromonordiazepam (aka desalkylgidazepam) and I've absolutely fallen in love with it. They only vary by the fact that where bromonordiazepam has a bromine, tetrazepam has a chlorine. Given tetrazepam's tendency for adverse effects and the understudied nature of bromonordiazepam taken on its own (as opposed to just being a diazepam metabolite, which it is) I'm going to begin exercising more caution with it. I took 45-50mg of it on no tolerance a few days ago to remain in this state of feeling like I'm being bathed in golden sunshine for around a week straight, slowly fading away. Most people don't exceed 10-15mg of it, but I wanted to see what a megadose of it would feel like given the fact that I don't black out anymore on even 20+mg of alprazolam after a months long tolerance break from all GABAergics.

That's another question I have for you actually (and any other BLers reading), have you noticed that your capacity to black out has faded as it occurred more and more? Teenaged me once cleared ~100 2mg alprazolam bars in a night and blacked out for example, and would often do similar shit because when in a benzo blackout, my actions are just me calling my friends and being like "Hey homie just so you know, I love you like a brother", all that sappy shit. Never anything belligerent like GHB or alcohol blackouts can induce. Nowadays it's incredibly difficult for me to halt memory formation with specifically benzos for some reason. I often take weeks-to-months long tolerance breaks in between periods of use too, which is part of why this is so surprising to me that the blackouts seem to become harder and harder to induce, given that it's not like I require more for the same effect. The last time I seriously blacked out was from mixing 500mg of carisoprodol with 1mg (for those reading quickly, mg, not ug) of LSD. Turns out carisoprodol wildly potentiates LSD, and even then it wasn't a full blackout, it was a kind of spottily on-and-off deal if that makes sense. My boyfriend who weighs ~68kg (I'm ~100kg) took 600ug of LSD alongside 500mg of carisoprodol and his memory simply turned back on the next morning. The trip was absolutely insane, felt more like 2-4mg of LSD alongside something like GHB or benzos in my personal opinion.

Also @Mana0909 I greatly appreciate the detail and depth of experience and all communicating with you, thank you for sharing your experiences and the knowledge synthesized from those experieneces not just with me but for future readers of this thread on BL!
 
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