which antidepressant has made u feel the best?

[Anon54]

benzos arnt working for be i had 150mgt temaze today even with a bit of pot and codeine but barely feel a thing.

I got presribed pristiq but only took it for a weak cuz it kind of made me more restless but im not sure if i took it long enough for my body to get used to the side effects.
wiki states pristiq peaks from 3-14 days fully.

I tried mirtazepne bt it gave me kind of luicid dreams & felt trippy like a low does of acid or something but it did help me sleep.

im taking a low dose antipychotic now but its making mefeel more depressed but has cured my insonia.

i want smeothing thats gunna give me motivation.

I used tramadol for 4.5 months & it worked wonders. it's an SNRI but can only be prescribed for pain. pitty cuz its a good AD. (effexor is suppose to be closely related to tramadol)

i wanna try one cuz i need motication & feel depressed.

any suggestions? I dont want anything thats going to make me act weird. & i dont wanna keep taking benzos cuz i seem to have a tolerance.

just one pristq tablets effected me more than all the drugs ive taken today.

theres got to be a practical AD out there.

im leaning towards either effexor or pristiq. maybe lexapro becase its suppose to have the least side effects but u need to take it for 6 weeks before it starts.

with pristiq (not so sure about effexor) it takes at most 2 weeks to peak.

is there anyone who has tried both effexor & pristiq & could tell me which is better?
I think pristiq only comes in extended release to but effexor comes in instant release. Is this corroect? cuz id prefer the instant release so it doesnt interfear with my sleepingmeds when i wann go to bed

so is there anyone out there who has found a good antipressant?
maybe i might have to wait till they make the DSNRIs.
but i think effexor slightly reuptkes dopamine too. not so sure about pristiq
I know pristiq is effexors main metabolite but i here different experiences between the 2
Do they have the same effct?

anyone please help with suggestions ive been depressed for some time now & wanna just be a functional human being. even benzos arnt working any morel. atleast i get an effect from ADs unless benzos unless i take a very hig dose

thanks for any input. last time i chose the wrong AD it gave me a panic attack so im a little scared to try the wrong one. i want a list of ones people get te most success out of

i was thinking about asking about pregnabullin. but if can barely feel 40mg diaz i dought prenabullin would be any use to me.

anyways i got downers already. im mainly interested in antideppressants to give me some motivation.

 

[Mugz]

I have tried multiple anti depressants and non of them really have much of a positive effect and made me feel really good, some have worked better than others and as everyone is different it is going to be hard to give you a good answer to your question. The best one that I tried was Trazodone although it could leave me feeling a bit groggy in the morning.

Venlafaxine was not a very good drug for me, it had me feeling super sick after 1 day of use and I couldn't function on it.

You can't really know which drug is going to work best for you based on other peoples experience. I would advise you to go through all of the options and possible side effects and talk with them about the history with things that you have alrelady tried and drugs that you wouldl like to give a go. You could mention tramadol and it could get prescribed off label but that is unlikely.

Hope you can find something that works for you because I know how hard it is to be suffering terrible depression and not have any success with the medications that are given to you.

 

[Allein]

I've copied this in form a post elsewhere (because I'm a lazy git!)

Citolpram - made me suicidal and caused hallucinations, really not a pretty , the physical nausea paled into insignificance compared to the rest of the side effects.

Lofepramine - I was on that for a few month last year when things were really bad (along side Chlorpromazine) - but it was giving me really bad dreams and I'm not normally bothered by such things, that and circulation problems, very cold feet and hands as well as making me really apathetic, so I came off.

Prozac - Just made me throw up violently

Sertraline - Seemed OK for a few weeks albeit made me feel very emotionally compressed then I had some internal bleeding so came off of that.

Mirtazapine - Just made my derealization much worse, ended up having a car accident.

I've agreed with my GP that for now I'll just leave them alone, I know that many people say that if you give then long enough the side effects lessen but i have a life to lead and a job I have to hold down.

I really wish the ADs has lived up to my expectations especially SSRIs, I had kinda hoped that some of problem were down to my years of MDXX abuse and that an SSRI would really help. this was BS I've been a mess for years allot of what gone down goes way back into my childhood.

Sorry I couldn't be more positive, I don;t think Benzos or opiates are going to help you in the longer term, they will just turn into more problems IME.

I may well be going back to my GP soon to try another as things haven't been that great of late, I'll be sure to post....as long as i survive the next car crash

Best Wishes

 

[Tripman]

Mirtazepam: Made me sleep excessively at low doses and trip out at higher doses. No benefit was noticed from usage of this drug.

Pristiq: Sent me beserk. I was super manic on this medication and now I suffer from hypomania with my Bipolar II disorder but I was fucking running around like i'd been smoking shards. It was dreadful for me.

Escitalopram: Lasted on this medication the longest, don't think it had any benefits or side effects except if i didn't take it i got visual hallucinations... I tried to kill myself 3 times on it so i'd say it didn't work.

Heading into the anti-psychotic range:

Olanzapine: Walking coma.... Sedative at night, fairly good for a rest but nigh on impossible to wake up in the morning. Then the rest of the day was spent in a catatonic state... Felt like a zombie.

Quitiapine/seroquel: Low doses are fantastic for sleep and suppressing impulses. High doses are similar to zyprexa, make you very very comatose during the day, i could take 6 hours to do something that should take me 20 minutes on 1000mg (high dose)

Thorazine: The Chemical lobotomy, steer clear is all I will say. Fucking shitful.

Zuclopenthixol/clopixol/acuphase: 2 day coma from this injection... Not great but good for dealing with non compliant psychotic bipolar bears

 

[Allein]

Thorazine : We call that by the generic Chlorpromazine in the UK (assuming your from the US) - didnt list it as I didnt really count it as an AD but yeah I agree avoid unless you want to become the walking dead.

I'm also assuming Mirtazepam is the same as Mirtazapine - made me feel just like I was starting to come up on acid, exactly the saem feeling i get when I have a bad derealisation episode. My doctor said he thought I would tolerate it well...I ended up crashing my car !

 

[Tripman]

Nah i'm from australia and we call it lygactal or chlorpromazine but i was speaking to the majority here that would know it as thorazine.

Oh and mirtazepine is what I meant. I've taken like 16mg of estazolam tonight and pretty bent.

Thorozine... the chemical lobotomy... 100mg of that and I was knocked out. Nothing apart from zuclpenthixol has put me out like that. Well And local anaesthetics ...

 

[effie]

edit: Didn't even answer your specific questions, sorry.. Effexor is IR and MR. I prefer MR, fewer side effects. I beliebe Pristiq also comes in an ER version. There is absolutely no reason your Dr would recommend Pristiq before you'd tried Effexor in my eyes except money or being pushed by drugs companies.

All antideps can take 2-6 weeks to reach peak effect so it is worth sticking with one for at least 2 weeks. I wasn't aware that Lexapro (escitaloptram) took longer than the others to kick in - it is a pretty universal rule.

Venlafaxine works really, really well for me. It is not exaggerating to say it has probably saved my life in combination with CBT.

General info below:

Pristiq is desvenlafaxine, effexor is venlafaxine. Logical scenario there would be to start with venlafaxine, and if that agrees with you but isn't packing enough punch step up to desvenlafaxine. As you said desvenlafaxine is the main metabolite of venlafaxine. They will work in the same way, same as citalopram and escitalopram, but just giving the active metabolite can be more effective. Usually you start with the citalopram/venlafaxine before progressing to escitalopram/desvenlafaxine if they didn't work. I kinda think they are a bit of a drug company ploy to make a more expensive verson of an existing drug personally.....

Antidepressant prefferance and response is incredibly personal and varies a lot (as you will notice!)

Broadly speaking most are similarly effective so it often doesn't matter which you start on but be prepared for the possibility it might take a few goes to find the best one. There are several different classes: (I'm afraid I don't know brand names, we don't use them much in the UK)

SSRIs - usually first line - fluoxetine/prozac, citalopram, escitalopram, sertraline, paroxetine etc. Side effects mostly GI (nausea, bloating, diarrhoea) and sexual disfunction. if you read the internet they don't tend to be popular but in my experience they are usually well tolerated with minimal side effects and are pretty safe in overdose. Stopping them can produce a "discontinuation syndrome" - headaches, "bran zaps", irritibility etc which some people find severe but most manage okay. Changing to one with a long half life such as fluoxetine can help. SSRIs only act on your serotonin system, increasing levels in your brain.

SNRIs - "next generation" antidepressants, main one is venlafaxine but also desvenlafaxine and some newer ones I can't remember. Often tried if two SSRIs have been tried and not worked. Side effects can be worse - nausea, insomnia, muscle tension, lack of appetite - but personally I found they went in a week or two and venlafaxine works really well for me. Make sure you increase your dose up slowly, ideally start on 37.5mg and titrate up.

Both SSRIs and SNRIs can be stimulating, so you should take them in the morning and they are good if you have a lack of energy as one of your main symptoms.. they can mess with yor sleep but its usually short term.

Mirtazepine is a newish one which is quite popular - it's a tetracycline antidepressant (there aren't many others in this class) and is often a second line like venlafaxine. I have seen it work really well for a lot of people. It is sedating, so best taken in the evening and works well if insomnia is a problem. It can increase your appetite. It affects both the noradrenaline and serotonin system.

The other common-ish class is the tricyclics - these aren't so popular now as they tend to have more side effects and can be fatal in overdose (by interfering with your heart rhythm). Side effects are mostly anticholinergic - dry mouth, difficulty urinating, variations in body temp.. they are also pretty sedating (usually). They include amitryptylline, lofepramine, dospulepin and imipramine. Some antipsychotics and antihistamines are also trycyclic (eg chlorpromazine, promethezine, loratadine).

Most people respond to at least one, but not everyone. My theory behind them is they don't fix everything and make you happy, they remove the awful all-pervasive black cloud that stops you living your life. It's the starting to live your life again that really helps lift depression (seeing friends again, enjoying activities, even just getting out of bed..) They probably are handed out too readily, but I believe true depression is a disease like any other, albeit with psychological and social aspects as well as biological, and the antidepressants treat the biological part of it. Getting out and about and living your life helps the social side, and things like CBT or counselling address the psychological side. They are all linked in my mind so when one area improves, the others tend to as well.. but it's important to think about all the different aspects to your depression.


..blimey I've written fuckloads! Bored Sunday and an interest/experience in depression, hah.. good luck in finding one that works for you

 

[K'd-OUT-in-AZ]

I've tried Effexor, Cymbalta, Zoloft, & Wellbutrin. The most effective one was Zoloft which is what I'm currently on. It helps for the anxiety & depression with little to no side effects and sexual dysfunction is the only bothersome one. The least effective one was Wellbutrin because it caused so many side effects including irritation, anger & compulsions. I simply didn't feel good on it. The Effexor & Cymbalta worked to a certain extent, they helped with my fibromyalgia.

As for your comment on pregabalin, it doesn't matter if you need to take 40mg of diazepam to get high, tolerance to benzodiazepines doesn't really matter when switching onto pregabalin. Only to a certain extent. The effects of pregabalin are rather different to benzodiazepines. The only similarities being sedation & anxiolysis. Pregabalin is less sedating but in my opinion it's a better anxiolytic. It also has anti-depressant qualities. 300-450mg are good doses. In studies 450mg of Pregabalin has been shown to be roughly equivalent to 4mg alprazolam. The duration of pregabalin is 8-12 hours depending on the dose you take. I highly recommend you try it.

 

[highhooked]

Suboxone.

Goodbye anxiety and depression. Hello energy and motivation. Just tiny tiny doses.

 

[Allein]

^^^

Really , does anyone know of they prescribe this for depression in the UK?

 

[highhooked]

They dont prescribe it in the USA, but they definitley should. I use it illegally...shhh dont tell my doc.

If someone isnt already dependent on opiates i bet .25mg and they will instantly see a difference. And its easy to taper off of it too if you have to.

O and it lasts forever.

 

[Allein]

sounds great but I have very high addiction potential and have somehow managed to avoid opiates so far so probably not for me, I'd just take the lot in one day

 

[Anon54]

effie u said effexor u can get in IR. instant release?
cuz i was wondering weather u could get either effexor or pristiq in extended release.
i dont wanna find myself still stimulated when i wanna tka eme sleeping meds.

im sure prtisiq only comes in extended realease but not sure about effexor

I loved tramadol & effexor is suppose to be its closest related cehmical or something so id probably like that too.
although the opiate effect of the tramadol probably made the jittery side-effects more barable.

u know the dr presribed me trmadol for depression beleive it or not he have me 180 pills 160 100mg tie realease & 20 50mg instant. cuz i liked t chew a 100mg & than ake a 50mg instant. cuz i thought 150mg was just right.
any more & it was to stimulating. i was getting valium there too but when i when they found out i went to another suirgery to get valium/temaze/xanax i got cut off. but honestly i said i suffered from migranes & depression & got tramadol. I wish i didnt fuck that up. u dont have to wait a month for tramadol to start working either. it should be prescribed for depression. it was easy t quit. i only tapped for a week. but i didnt have a little valium help

for anyone who doses know if u redose small amounts of tramadol over the day instead of taking it all at once u get an inhanced opiate effect out of it if ya looking for the opiate effect & not the SNRI. it seems to balance at about 100mg

 

[Anon54]

As for your comment on pregabalin, it doesn't matter if you need to take 40mg of diazepam to get high, tolerance to benzodiazepines doesn't really matter when switching onto pregabalin. Only to a certain extent. The effects of pregabalin are rather different to benzodiazepines. The only similarities being sedation & anxiolysis. Pregabalin is less sedating but in my opinion it's a better anxiolytic. It also has anti-depressant qualities. 300-450mg are good doses. In studies 450mg of Pregabalin has been shown to be roughly equivalent to 4mg alprazolam. The duration of pregabalin is 8-12 hours depending on the dose you take. I highly recommend you try it.

WOW 4mg of xanax. i may have to ask the dr about it. whats in usully precribed for? anxiety or something else.
cuz i need a chage. took 150 temaze yesturday didnt do anything. my 400mg codeine was stronger & i havnt had benzos for a while.

the zyprexa i take works stronge. i swticed from seroquel which was even stronger. they coem in 300mg at the most. one of them will have u asleep in less than an hr. it may help for those pl experienceing w/d & are having concerns abotu insomnia. seroquel has little side effects unless u start taking em every day. even 100mg would have someone out.


I know its a bit off topis but grapefruit juice always works for xanax & temaze we well as valium. right?
i take codeine regually anyway so it probably wouldnt help cuz it lowers te conversion to morphine

wiki says prsitiq peaks in 3 days. 14 max. is it the same for effexor.

so yeah wanna know if there is an instant release for effexor. im assuming IR stands for instant release
gives me insomnia so i only wanna be feeling it during the day before i take my downers




quoted from wikipedia
Multiple double blind studies show venlafaxine's effectiveness in treating depression. Venlafaxine has similar efficacy to the tricyclic antidepressants amitriptyline (Elavil) and imipramine, and is better tolerated than amitriptyline. Its efficacy is similar to or better than sertraline (Zoloft) and fluoxetine (Prozac), depending on the criteria and rating scales used

it anyone could find any links comparing the efficancy of AD that would be great. i wanna take the best one i can find with little side effects. cuz im sick of depression

www.askapatient.com
is a very good link for anyone wanting to read comments about different meds. ppl rate there meds.

 

[Mugz]

venlafaxine made me terribly ill for the first day that I started taking it, I probably should have given it a longer shot but after the negative effects I got from just one day of taking it I didn't take any more of those pills ever again, felt like poison.

 

[percozakk]

I am priscribed a combination of Citalopram(an antidepressant ) and. Topiramate(a mood stabilizer because I'm borderline bipolar. ) the two together though are really helpful. Occasionally I may have a bought of depression but I get nowhere near the lows I got before and it last way shorter. I hope this is helpful.

 

[K'd-OUT-in-AZ]

I've tried Effexor, Cymbalta, Zoloft, & Wellbutrin. The most effective one was Zoloft which is what I'm currently on. It helps for the anxiety & depression with little to no side effects and sexual dysfunction is the only bothersome one. The least effective one was Wellbutrin because it caused so many side effects including irritation, anger & compulsions. I simply didn't feel good on it. The Effexor & Cymbalta worked to a certain extent, they helped with my fibromyalgia.

As for your comment on pregabalin, it doesn't matter if you need to take 40mg of diazepam to get high, tolerance to benzodiazepines doesn't really matter when switching onto pregabalin. Only to a certain extent. The effects of pregabalin are rather different to benzodiazepines. The only similarities being sedation & anxiolysis. Pregabalin is less sedating but in my opinion it's a better anxiolytic. It also has anti-depressant qualities. 300-450mg are good doses. In studies 450mg of Pregabalin has been shown to be roughly equivalent to 4mg alprazolam. The duration of pregabalin is 8-12 hours depending on the dose you take. I highly recommend you try it.

 

[Tripman]

Suboxone is honestly the BEST anti-d in my opinion, unfortunately i'm tapering up to 32mg's a day which is a tad extreme.

Pregabalin is FANTASTIC for restless leg syndrome. 4mg of xanax however is just nothing. Maybe my benzo tolerance but i need 5 bricks for any relief.

 

[laCster]

60-90mgs DXM combined with 15-30mins of exercise daily is the most effective for anxiety/depression for me. i've tried numerous SSRI/SNRI's, but none did the 'job' for me. however, it is possible that they might work for you.

side note....
while benzos/opiates/amphetamines might seem the best for short term, they are definitely not worth your health in the long run.

 

[Tripman]

Well yes that is along the same lines as using bupe for an anti d. Only problem is potential addiction...