Ah, I completely missed out on that whole generation of noids, hadn't even heard of them until recently, but yeah I've heard JWH01 will get you utterly wasted. How's it stack up to the current noids being sold (AKB, PB-22, etc)?
As for negative effects, the only ones I've experienced are elevated bp and a major panic attack from smoking around 20 mg of 5fakb48. If you're looking for long-term damage, toxicity, etc from these noids, there really is not much research data out there at all, so smoking them is a risk. I guess the negative effects of AM-2201 are kind of moot now, as it's been an illegal drug for ages, and pretty hard to get hold of.
But yeah, if you've never smoked a noid before, BB-25 may be a good place to start; it was the first one I tried. Duration is excellent for a noid, with high doses lasting (me) up to four hours. It's quite sedating, with a strong body high but minimal head-fuck. OP if you decide to use noids, are you gonna be smoking them in a herbal blend, or in the pure form? I only ask cause it's very easy to smoke far too much if you're using pure.