Easy…..the legendary…..the infamous….the one & only…. Brompton Cocktail
Invented/concocted in the 1890’s in the United Kingdom’s Royal Brompton Hospital for terminally ill patients to make them comfortable, ease their suffering & pain, while having the patient alert and social/talkative, and yes, even euphoric
Original Brompton Cocktail formula : …..essentially an oral Speedball
Diacetylmorphine (Heroin)
Cocaine HCL
Chloroform
Cannabis Indica
Ethanol (mostly Gin)
I have been using a hybrid Brompton Cocktail for many years for chronic pain…..the most essential components are absolutely staple. Period. A potent mu-opioid agonist, a dopaminergic stimulant, a rapid acting benzodiazepine with robust anxiolytic & muscle relaxant properties, plus gabapentinoids and ethanol ….my custom cocktail
Methadone 100-125mg
Methylphenidate (Ritalin) 50-70mg IR
Diazepam (Valium) 20-30mg
Alprazolam (Xanax) 1mg
Pregabalin (Lyrica) 300mg
Ethanol-Gin 2.oz every 40min or so
For a tolerant user, 240lbs / 6’ male this cocktail is very effective…..it’s not weak by any means, but not in the danger zone in any way….for ME
Adding a dopaminergic stimulant to an opioid is absolutely essential ….it enhances the analgesic painkilling properties of the opioid, it reduced sedation and improves cognitive function and enhanced vigilance…..also, both have VERY robust mood-boosting properties and can be extremely euphoric & pleasurable
Valium is the best benzodiazepine of earth, Anxiolytic & muscle relaxation
Xanax is the most euphoric benzodiazepine with antidepressant properties due to the significant dopamine increase as compared to all other benzodiazepine compounds
Pregabalin (Lyrica) 300-450mg is simply amazing to add to a cocktail…..Very robust anxiolytic & mood-boosting properties, in addition to being an anticonvulsant gabapentinoid
Oxycodone is the most euphoric potent opioid painkiller ever synthesized (besides Diamorphine & Dilaudid) but I’m on Methadone 100mg daily ….which is also reasonably pleasurable, and a VERY potent & effective long acting opioid analgesic
….the oral Brompton Cocktail

(all tablets pulverized and powder in glass dissolved in hot water, add juice to mask the bitter taste and drink. 30-45min onset creeps in / 1h near full effects and you’re NICE
a Speedball (Oxycodone & Ritalin) (Heroin & Cocaine) ….Ive slammed both …..VERY pleasurable & euphoric. A euphoric opioid and a dopaminergic stimulant. Hands down ultimate drug combo