Bupe what to expect from 10mg percocet?

[ongos]

When taking an aspirin for pain relief the pain is present but slowly subsides, not sure what the feeling will be with an opioid analgesic. Does the pain simply vanish?

Also...

"μ-Opioids, such as hydrocodone and tramadol, may improve OCD symptoms.[89] Administration of opiate treatment may be contraindicated in individuals concurrently taking CYP2D6 inhibitors such as fluoxetine and paroxetine."

Is percocet this type of opioid or not?

 

[Bliss26]

The pain slowly subsides between 30-60 minutes.
If you've never had an opiate and are not looking for a buzz wou may want to eat first. Some newbies get a sick tummy from opiates on an empty stomach

Re the SSRI a- yeah "they" say use caution mixing opiates and SSRI s but I'd guess 90% of is are on both and all is well.

 

[iodo]

The pain doesn't simply go away, the opiate just manages the pain. The pain is usually still there, but it isn't in the foreground of what's happening.

When I sprained my ankle a couple of years ago I got a good amount of hydrocodone. It took most of the pain away, but it would still ache every once in a while. But the big mistake of it was that the opiates gave me confidence that I was more healed than I really was. I walked on my foot too early and ended up slowing down the healing process. So don't end up overworking yourself because you feel better.

 

[The Doc.]

With a percocet its basically going to act the same way by letting the pain slowly subside over about a half hour but the pain relief will be greater compared to an aspirin. They should last about 4-6 hours until a redose may be needed to continue controlling pain.
Percocet is oxycodone quick release mixed with acetaminophen (Tylenol).

As others have said the pain may not vanish but be well controlled letting you not be in agony. Although depending on your level of pain your first time taking opiates may make you completely numb and let you feel nothing at all. As time goes on and tolerance increases this will no longer be so and the opiate will simply manage but not eliminate pain.

Yes oxycodone is similar to hydrocodone and tramadol although tramadol is an atypical opioid analgesic with additional serotonin norepinephrine reuptake inhibiting effects. Basically Tramadol is an atypical opioid because it is a serotonin-norepinephrine reuptake inhibitor along with the fact it's a very weak opioid agonist compared to others such as oxycodone or hydrocodone.

Now CYP2D6 metabolism has been shown to play a big role in how effective oxycodone controls pain. The same goes for CYP3A4 metabolism.

CYP2D6 blockade has been shown to reduce subjective pain threshold for oxycodone by 30%. So to put it simply studies have shown CYP2D6 inhibitors to decrease the effects of oxycodone on patients using it for pain relief.
Whereas CYP3A4 blockade had a major effect on all pharmacodynamic assessments and subjective pain threshold increased by 15%.

This shows by inhibiting the CYP3A4 gene, pain threshold was increased while taking oxycodone. Yet CYP2D6 inhibition was shown to decrease the patients pain threshold making the oxycodone less effective.

Studies have also tried using CYP2D6 inhibition to see whether the failure to activate oral opiates in people with the defective gene was a protection factor in opiate dependence.
A study using people dependant on oral opiates suggests that the CYP2D6 defective genotype is a protection factor for oral opiate dependence. This suggests inhibition of the CYP2D6 gene may reduce the chance of addiction and dependance in patients taking oral opiates. In my opinion we still need to study this claim further and right now i believe inhibition of the CYP2D6 is not a very practical way to avoid dependance in patients taking oral opiates. Researchers could be onto something big though.

 

[thelung]

If this is your first time doing opiates, I'd just eat the pill like any other pill. You'll feel it. i'd avoid snorting the pill(s) just take them orally. Good luck and Godspeed my friend

 

[The Doc.]

If this is your first time doing opiates, I'd just eat the pill like any other pill. You'll feel it. i'd avoid snorting the pill(s) just take them orally. Good luck and Godspeed my friend

Your right here snorting oxycodone is not very efficient because the oral Bioavailability is so high already. Pills with low oral B/A's such as hydromorphone make more sense to snort. But on the other hand people with deficiencies in the genes responsible for absorbing oral oxycodone (for example the CYP2D6 chromosome) snorting would give them a better B/A than oral use would. A small amount of the population have this deficiency or take SSRIs which inhibit the genes responsible for absorbing oral oxycodone so for them they would find intranasal oxycodone to work better than oral oxycodone. Myself the first time I took my oxycodone by mouth cause my nose was plugged back when I was a teenager, I thought gee why have I been snorting the pills when I feel it almost twice as better taking it orally. So from then on I only take oxycodone by mouth.

 

[mabzie55]

Depends how much pain you're in.

For me when I had no tolerance, that dosage would completely get rid of minor pain.

Strong pain it will dull it and make you feel much better.

Opiates are the best painkillers and it will be 100x more effective than aspirin.

 

[fizzymk]

When taking an aspirin for pain relief the pain is present but slowly subsides, not sure what the feeling will be with an opioid analgesic. Does the pain simply vanish?

Also...

"μ-Opioids, such as hydrocodone and tramadol, may improve OCD symptoms.[89] Administration of opiate treatment may be contraindicated in individuals concurrently taking CYP2D6 inhibitors such as fluoxetine and paroxetine."

Is percocet this type of opioid or not?

Like others have said on here, your pain wont simply vanish...only a few drugs that will make that happen, but since you are new to opiates, you definitely dont want to take ANY of those just yet, youd probably throw up or get VERY high.

The perc/ vicoden will kick in within about 30-40 minutes, and more than likely you will feel it in your head first, look for slight euphoria, suddenly feeling like everything is great with your life, you feel motivated to do just about anything, etc. it will lessen the pain you have, but the pain will still be there, but not as bad, usually people will take another pill once they feel the effect of a single one, thinking more will equal more pain relief, more good feelings in your head...and they are right, this will work, but will lead you down a very bad road...abusing opiate painkillers long enough and frequently enough, WILL lead to heroin eventually, it becomes a cost issue at some point, as opiate pain pills are pretty pricey on the street compared to heroin anyway.

Good luck. If you can use these pills for the pain you have and NOT get too used to the good mental effects it will give you, it is do able, just DO NOT start taking more than prescribed or longer than needed, it is ridiculous how quick and easy it becomes to get EXTREMELY addicted to opiates, and Heroin is the biggest and baddest of opiates, basically its a percocet on steroids, if that makes any sense!

 

[Bliss26]

Just relax OP I think you got info overload here, lol

Don't forget though if it really is your first time you may feel fuzzy, happy, nausea, talkative,sleepy have impaired judgement etc.

This is not a good time to;
- babysit
-sign a prenup or any legally binding documents
- drive (not the 1st time, sry)
- operate heavy machinery
- fry bacon in the nude
- take any other CNS depressants like alcohol, Ativan, sleeping pills

Feel better soon.

 

[ongos]

I believe dosing is suggested every 1-2 hours if pain persist. Does that mean the effect vanished within 1-2 hours then?

 

[mabzie55]

Like others have said on here, your pain wont simply vanish...only a few drugs that will make that happen, but since you are new to opiates, you definitely dont want to take ANY of those just yet, youd probably throw up or get VERY high.

The perc/ vicoden will kick in within about 30-40 minutes, and more than likely you will feel it in your head first, look for slight euphoria, suddenly feeling like everything is great with your life, you feel motivated to do just about anything, etc. it will lessen the pain you have, but the pain will still be there, but not as bad, usually people will take another pill once they feel the effect of a single one, thinking more will equal more pain relief, more good feelings in your head...and they are right, this will work, but will lead you down a very bad road...abusing opiate painkillers long enough and frequently enough, WILL lead to heroin eventually, it becomes a cost issue at some point, as opiate pain pills are pretty pricey on the street compared to heroin anyway.

Good luck. If you can use these pills for the pain you have and NOT get too used to the good mental effects it will give you, it is do able, just DO NOT start taking more than prescribed or longer than needed, it is ridiculous how quick and easy it becomes to get EXTREMELY addicted to opiates, and Heroin is the biggest and baddest of opiates, basically its a percocet on steroids, if that makes any sense!

Gonna have to second that.

I started opiates by prescription for legitimate pain relief-- was addicted and buying pills immediately after my prescription was gone, and was doing multiple times heroin daily within 2 years.

 

[mabzie55]

I believe dosing is suggested every 1-2 hours if pain persist. Does that mean the effect vanished within 1-2 hours then?

No, you will have effects 4-6 hours depending on many factors.

I think they mean that if you still have pain after 1-2 hours of dosing you can take another.

 

[ongos]

would percocet make me drowsy? Some guy said he does not use it because he does not want it making him drowsy. Another person mentioned it makes you get up and do stuff, which is the opposite of drowsy.

 

[The Doc.]

When you first take it most likely you will be drowsy but it's when you become addicted to the percocet that they start giving you energy instead of making you drowsy. Once addicted you don't have any energy at all until you take a percocet then you need another one a few hours later to keep going.

 

[ongos]

It's best to avoid percocet before bedtime right? I thought I read that somewhere but not sure what the reason is. Sleep apnea?

 

[mabzie55]

It's best to avoid percocet before bedtime right? I thought I read that somewhere but not sure what the reason is. Sleep apnea?

I've never heard that.

Unless you already have some trouble breathing during sleep, sleep apnea, etc you should be fine. Especially with a low dosage like 10mg.

 

[Bliss26]

It only makes you drowsy if you take more than u need.
For example: if you're very opiate naive and you're lucky enough to feel good on 5mg. If you took 15mg you'd be tired , if you took your 5mg you'd feel slightly energized

 

[Bliss26]

Pretty sure you're golden after four days or so but it's not my area so if wait for someone to confirm or maybe do a search .

 

[Thomas29]

Not Sure what the Question Is Exactly Here OP?

 

[ongos]

I'm anxious in trying out the opioid at 10mg, not sure what to expect. That was the question.

Not Sure what the Question Is Exactly Here OP?