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Help! What is the relation between 2C-X family and DOx family ?

Dr.Methyl

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Jan 14, 2025
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I have some experiences with compound from the 2C family and other from the DOx but I've never tested a 2C-Y and its DOY analogue.

For example I've tried 2C-B and 2C-C but never DOB nor DOC and I tested DOM and DOT but never 2C-M/D nor 2C-T... It is logical to think that the DOY will do the same effect as 2c-Y but with a longer coming up and longer duration or I am wrong and they're completely different experience ? I like 2C-C because it is sedative and don't like 2C-I because it is very stimulant, so can I expect that DOC will also be some kind of sedative despite its amphetamine structure and DOI the most stimulating of its family?

How do you compare a 2C-Y and its DOY brother ?

if I give you blindly and an halogenated 2C-X at moderate dose can you guess which one it is, or the effect are too close to have an idea ?

Thank you in advance,

Dr.Methyl
 
I don't have enough experience to give you a detailed comparitive analysis, but in my limited experience the two are different drugs that may or may not share some core qualities.

I don't really find DOC to be particularly similar to 2C-C even though I'm primed to expect to see a relationship, but the color scheme of the the visuals that I get from them are the same. Unlike 2C-C, DOC is decidedly stimulating, but in a way that is easy to focus, channel, and relax into. An imperfect analogy would be the the relationship between 5-MeO-MiPT and 4-HO-MiPT — shared qualities, different materials.

I've heard many people see similarities between DOM and 2C-D, but for me they couldn't be more different. I feel no relationship at all. An imperfect analogy would be the the relationship between 5-MeO-DMT and 4-HO-DMT — really just completely different experiences where assignments may as well be coincidences.

I haven't ever had 2C-P so take this with a grain of salt, but DOPr honestly had a lot of the qualities that people ascribe to it. It was rich in very dreamy, cloudy, semi-dissociative qualities.
 
Of psychedelic phenethylamines I've used DOB, DOC, DOM, MDA, 2C-B, 25C-NBOH, 25-NBOMe, 25B-NBOMe, allylescaline, and Mescaline. Of them, DOM, Mescaline, DOB, and allylescaline feel the most "flat". DOC, MDA, and all of the 25X-NBXX's have a more "velvet"-y sort of feeling and are a little bit more visual and stimulating, more LSD-like in a way. The fact that DOB and 2C-B share a 4-Bromo group is noticeable in the style of visual and bodily feelings, as is the shared chlorine-related feeling between 25C-NBOMe and DOC. Visually, they'd be grouped as [Mescaline, allylescaline, 25C-NBOMe, MDA, DOM, and Mescaline] vs [25B-NBOH, DOB, 2C-B, 25I-NBOMe, and DOC], so it seems like halogenation gives it a visual style that moreso resembles the way that NMDA antagonists like ketamine and PCP can cause things to look vaguely like a PlayStation 2 game, as if light is reflecting differently.

They all have different headspaces which lead to different qualities cognitively though, energy levels and come-up time/duration overall vary extensively as well.
 
I've never had the chance to try any of the DOx compounds, but the relationship between them and their corresponding 2c-x relative is something I've always been curious about as well.

Re: DOM vs 2C-D - I have a lot of experience with 2C-D, and it sounds to me like DOM is a very different beast, almost opposite ends of the spectrum - their durations, potency and intensity are wildly different - but perhaps they are nonetheless on the same spectrum. Whereas something like 5-meo-dmt vs 4-ho-dmt don't even belong on the same spectrum if you ask me. I don't know, but Id be curious to try DOM.

It's interesting that 25C-NBOMe ends up being an exception in the way you lumped those compounds @Esperighanto
 
Yeah, DOM is a weird one. I get the impression that user experiences vary widely, and not just due to the wide individual variance in its dosage-response curve.

I liked it the two times I was able to try it. It felt hollow, but pregnant with potential. I never got to see what lay on the horizon, but it seemed like a deep pool. And yet others find it lush, rich, and colorful. For me, it felt like the psychedelic amphetamine equivalent of 4-HO-DiPT, something that doesn't feel at all like 2C-D to me.
 
but the relationship between them and their corresponding 2c-x relative is something I've always been curious about as well.
Technically a single methyl group, a single carbon at this corner of the molecule referred to as the alpha position is the physical difference between 2C-D and DOM. DOM could be called alpha-methyl-2C-D if you wanted to be extra verbose with it, but Shulgin was big on abbreviations.
It's interesting that 25C-NBOMe ends up being an exception in the way you lumped those compounds @Esperighanto
Yeah it had the same velvet-y charm of mescaline, allylescaline, DOC, and MDA, but 25C-NBOMe is uniquely a favorite of mine. I often refer to it as "acid meth" because it feels very similar to taking a large dose of methamphetamine and a light-to-moderate dose of LSD, but all condensed into like 6-8 hours total (assuming you're not redosing). If I were to pick a top 5 psychedelics I've ever used, it'd very likely be 25C-NBOMe, LSD, DOC, Allylescaline and Miprocin. Notice that both of the 4-chlorinated phenethylamines are on the list? They're absolutely stunning compounds, I wish they were more available.
Yeah, DOM is a weird one. I get the impression that user experiences vary widely, and not just due to the wide individual variance in its dosage-response curve.
I've not used Diprocin nor 2C-D to measure up to your comparison, but the first time I took DOM I thought I got a bunk batch, so I ended up taking 18mg of crystal orally. I was watching a series of documentaries about the evolution of hip-hop and certain musicians, and I noticed ~2-3 hours after dosing that I was sweating and shivering, pacing around in my apartment like I'd just dropped a few tenstrips of really good acid, but the visuals reminded me more of mescaline, a slithering drift of the textures around me settling in slowly. Once it calmed down, I returned to watching the documentary and realized that the conglomeration of glowing crystal-like shapes on the wall were not in fact some sort of "fae" entity (which for some reason, in that moment I blew off as just being normal?) but it was instead a complex shape and pattern that represented a variety of human emotions and actions, as well as the butterfly effect echoes of their impacts. I've since pushed DOM up to 45mg, and one of my most significant trips ever was on 25mg of DOM, 25mg of 2C-B, 40mg of Miprocin, and a couple hundred milligrams of 3-MeO-PCP that I chain smoked later that night once the shorter-lasting psychs wore off, hoping it would help me get to sleep.

It did not. My vision was overcome by dark tentacle/vine-like structures and I passed out into a DMT-like breakthrough experience, where I was shown every demon my brain damage has ever caused me to hallucinate being reconstructed out of these roots, growing out of the ground as if they were structures of nature itself. These then turned into a "Santa Muerta" type of deity/entity/spirit figure, whatever you'd want to call it. This entity told me that it was death, and it was also me. Since then, even when I stop using anything antipsychotic (for me cannabis makes me functional and normal, whereas 3-4 days without cannabinoid exposure I'm inseparable from a schizophrenic) I no longer see those demons or anything, just weird shadow people darting around and shit. It's a lot better than watching my mother walk into the room, shoot herself in the head, sobbing over her corpse for hours just for it to disappear without me even blinking, because it was a hallucination the entire fucking time.

My medical team's best guess right now is that I likely have a demyelination disorder, simply put it's like my brain just endogenously performs the equivalent of eating a fistful of benadryl or datura seeds if I don't adequately supply it with neuroprotectives (like cannabis) or neuroregeneratives (like psychedelics). It's a big part of why I trip so often, and in such high doses. It's made me as stable and functional as I've ever been. It also likely reflects part of why I can take somewhat monstrous doses of psychedelics though, despite DOM's somewhat "flat" or "hollow" character, 25-45mg of DOM would probably send most people into a crisis. Once when coping with the death of a friend I grew up with, I put ~25mg each of 2C-B, DOM, 3-HO-PCP and an eyeballed but massive amount (150-250mg) of ketamine onto a tray and insufflated the whole thing, dropping ~2/3 of a milligram of acid in an "acid smile" (one drop in each eye, remainder in the mouth). I proceeded to have a trip reliving his death, how it must've been to flip your car over a guardrail late on a cold, snowy Maine night and drown, alone, freezing in a marsh. For days afterwards I couldn't get the marshwater out of my mouth. In my life I've been an alright person, I don't think I'm bad necessarily but there's some monstrous shit I could've likely deescalated instead of further escalating to the point of permanent trauma that I'd rather not get into. That friend that died was unironically a fucking saint of a human, one of the brightest glowing souls I've ever met in my entire life. I've still got the clothes he made me, I'd literally kill somebody if they tried to take them, they're the last physical connection in this world that I've got to him. The trip brought up this weird trauma from growing up in the hospital terminally ill for a few years (just "chronically ill" now), the old "Why do all the other kids get to die but I'm stuck here suffering?" thing. When I'm dealing with difficult shit, I tend to trip as hard as possible to sift out my mind and utilize the enhanced neuroplasticity to try to cope as well as I can. Psychedelics overall are predominantly just cognitive reprogramming tools for me, my background in life is hacking/programming so I suppose it makes sense that the mindset extended.

In addition to the brain damage/likely undiagnosable demyelination disorder, I have lost all but 5-6 feet of my intestines, which is where many of the body's serotonin receptors are, so there's a chance that I just under-absorb many psychedelics. It's why I tend to insufflate every drug I can, some things just don't work when I eat them.
 
Re: DOM vs 2C-D - I have a lot of experience with 2C-D, and it sounds to me like DOM is a very different beast, almost opposite ends of the spectrum - their durations, potency and intensity are wildly different - but perhaps they are nonetheless on the same spectrum. Whereas something like 5-meo-dmt vs 4-ho-dmt don't even belong on the same spectrum if you ask me. I don't know, but Id be curious to try DOM.
Interestingly, their LD50 seem to converge. With DOM being the less toxic compound. I only have one experience with DOM and a handful with 2C-D (all of them after DOM). Apart from DOT at inactive dosage, this is the only 2C-x/DOx pair I have tried. And with the stars not aligning for the DOM day, my experience with it was very mediocre. Since reading more about the history of DOM, I'd like to give it another try, maybe with the isolated eutomer. However, despite the bad day for such an endeavour, the DOM behaved relatively tame at 5 mg. The little visuals I got on DOM where quite similar to what I later got to know on 2C-D.


Edit: This is of course old LD50 data in animals. I'm not suggesting trying any dosage known to be safe-ish with 2C-D with DOM. Regardless, there seem to be many pointers towards DOM being a relatively safe compound physiologically.
 
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DOM behaved relatively tame at 5 mg.
DOM is more of an "I need to get a ton of things done in a hyper attentive and effective manner" type of drug for my fiancee and I until we push it over ~15mg, meaning I'd assume that maybe 10mg or so for most people would be that point. Maybe try titrating up in 2.5mg intervals over a series of trips and edging your way up to the 12.5 range, I bet you'll encounter further psychedelia. It may also be wise to keep long-lasting benzos such as clonazepam (or another of similar duration) on hand in case you want to mute the trip, if I recall correctly you'd mentioned being particularly sensitive to serotonergic psychedelics.
 
DOM is more of an "I need to get a ton of things done in a hyper attentive and effective manner" type of drug for my fiancee and I until we push it over ~15mg, meaning I'd assume that maybe 10mg or so for most people would be that point. Maybe try titrating up in 2.5mg intervals over a series of trips and edging your way up to the 12.5 range, I bet you'll encounter further psychedelia. It may also be wise to keep long-lasting benzos such as clonazepam (or another of similar duration) on hand in case you want to mute the trip, if I recall correctly you'd mentioned being particularly sensitive to serotonergic psychedelics.
I heard of quite rich experiences with 3 mg already. In my experience, the bodyload was just not worth the little effects I got. Hence why I'd really like to try (R)-DOM in hopes of it being a better experience.
 
Edit: This is of course old LD50 data in animals. I'm not suggesting trying any dosage known to be safe-ish with 2C-D with DOM. Regardless, there seem to be many pointers towards DOM being a relatively safe compound physiologically.
I vaguely remember stories about when DOM was unleashed on the streets in haight-ashbury in ancient times as STP and people were taking it in mega high doses and ending up in the hospital. Not sure if that was just because they were tripping so hard they were going nuts, or if they were getting into physically dangerous territory.

Technically a single methyl group, a single carbon at this corner of the molecule referred to as the alpha position is the physical difference between 2C-D and DOM. DOM could be called alpha-methyl-2C-D if you wanted to be extra verbose with it, but Shulgin was big on abbreviations.
Yes that really close structure is what makes me so curious about how their subjective effects.
I always thought Shulgin should have named 2C-D as 2C-M for the Methyl.
 
I vaguely remember stories about when DOM was unleashed on the streets in haight-ashbury in ancient times as STP and people were taking it in mega high doses and ending up in the hospital. Not sure if that was just because they were tripping so hard they were going nuts, or if they were getting into physically dangerous territory.


Yes that really close structure is what makes me so curious about how their subjective effects.
I always thought Shulgin should have named 2C-D as 2C-M for the Methyl.
Afaik, there are zero known deaths from it. Not to say it can't get hairy, but I wouldn't worry with "normal people doses" at all.

"Since these latter had the original two-carbon chain, they were given names based on the identifier of the last letter of the amphetamine prototypes with a prefix that said, there are only two (not three) carbons in the molecule. Thus, there appeared 2C-M, 2C-B, 2C-I, 2C-E, 2C-T and on and on. And when modifications of them were made and found to be active, they were named with sequential numbers, such as 2C-T-2, 2C-T-7, 2C-T-21, and on and on."


The problem with phenethylamine nomenclature is how it grew organically. And Shulgin's whimsical nature did not help.
 
so can I expect that DOC will also be some kind of sedative despite its amphetamine structure and DOI the most stimulating of its family?
I would not count on this. All of the DOx seem to have a more stimulating body load, and a much longer timeline.

I've been able to try 2C-B, DOB, 2C-D, DOM (I still don't quite understand why he didn't name 2C-D 2C-M)

The DOx are almost all much longer lasting, noticeably more stimulating, and of the 2 I've tried, both had more of something akin to confusion at the peak especially in a hot climate. I feel like the DOx aso noticably raised my body temperature to a higher degree. I do NOT like taking DOx in a hot environment, ive done it a few times. The visuals are somewhat comparable IME of the 2cx and dox, but also unique. DOB visuals are more grandiose and intricate. DOM and 2C-D both cause prinarily intense color saturation, but in a different way. If that holds up across the board I don't know.

Also taken 25B, as well as DOPr tho I've not tried 2C-P.
 
Also taken 25B, as well as DOPr tho I've not tried 2C-P.
25B-NBOMe, -NBMD, -NB, -NBF, or -NBOH? And how was the DOPr, I already hear people complaiin that 2C-P lasts too long so I can't imagine DOPr.

Last night I tried to split 6mg of DOC with my fiancee, but I think in the action of crushing the tablets, his acute nicotine withdrawl, or some cruel act of the gods, I ended up not only ingesting virtually all 6mg of DOC but also 4.5mg (6 tabs) of DOB almost immediately after, making the classic "oh these ain't shit!" mistake. I woke up in the middle of the night shrieking to a calf cramp. I awoke this morning, eyes still blown the fuck out, visuals like numerous tenstrips of good acid, noticeably probably closer to the come-up than come-down, and it's been eleven hours.
 
25B-NBOMe, -NBMD, -NB, -NBF, or -NBOH? And how was the DOPr, I already hear people complaiin that 2C-P lasts too long so I can't imagine DOPr.

Last night I tried to split 6mg of DOC with my fiancee, but I think in the action of crushing the tablets, his acute nicotine withdrawl, or some cruel act of the gods, I ended up not only ingesting virtually all 6mg of DOC but also 4.5mg (6 tabs) of DOB almost immediately after, making the classic "oh these ain't shit!" mistake. I woke up in the middle of the night shrieking to a calf cramp. I awoke this morning, eyes still blown the fuck out, visuals like numerous tenstrips of good acid, noticeably probably closer to the come-up than come-down, and it's been eleven hours.
Sorry i wasn't more specific. 25B-NBOMe.

Jeevus 4.5mg of the DOB alone would have me in a gnarly state. Never tried DOC sadly
 
Jeevus 4.5mg of the DOB alone would have me in a gnarly state. Never tried DOC sadly
I actually went to sleep within a few hours of dosing, waking up though it feels like it did that thing acid does where you dose then go to sleep -- it waited for me --

All of a sudden it's like I took the tabs a few hours ago still, bro I am tired. Nervous to take bupropion for any energy as it might potentiate possible releases of norep or dopamine from the DOB/DOC, so I might just caffeinate my way through the day and see how I do.
 
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