• 💊 OTHER DRUGS 💊 Welcome Guest
    Posting Rules Bluelight Rules
    Notable Threads 1 Notable Threads 2
    Dangerous Combos Addiction Support
    Emergency Services Benzo Guide v.1
    Addiction Stories Scary Case Studies
    Biology, Pharmacology & Drugs 101
  • Select Your Topic Then Scroll Down
    Alcohol Bupe Benzos
    Cocaine Heroin Opioids
    RCs Stimulants Misc
    Harm Reduction All Topics Gabapentinoids
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums

Benzos What is an equivalent dose of sublingual midazolam to oral clonazepam, nitrazepam or diazepam for example.

D

Drag2019

Bluelighter
Joined
Jan 4, 2020
Messages
314
Location
The City Of Atlantis
Keep in mind I'm wondering about sublingual absorption which should be much higher than oral absorption but I'm unsure what dose is equivalent to more common high oral ROA absorbing benzos like clonazepam, nitrazepam and diazepam?

I got 15mg Midazolam Tablets for oral roa that I don't know how small I can accurately measure out a dose or break apart the tablet into?
 
Last edited:
Well from what I remember sublingual Midazolam is very high close to I.V. Midazolam and the equivalency chart which was only 1 that even had Midazolam listed made 1-4mg a comparable dose? I got 15mg Tablets meant for oral dosing so if I break that into 4 pieces I will have roughly a 3.5mg dose but if that might be equal to far more than 1mg of clonazepam when taken via I.V. which should be comparable to sublingual absorption I think so that's a big difference and I'm on methadone and GABAPentin so I need to proceed as cautious as possible hence I'm really hoping to find anecdotes of personal use with Midazolam sublingually they can share or even someones opinion based on a lot or reading about the topic?


After reading about it I've learned it's extremely bitter tasting which would make it not ideal for sublingual use.
 
Wow, Drag, it looks like you may answer your own question. I got nothing but I figured I’d kick up your thread since you asked back in March.
 
Lol thanks... I'm struggling to find any official medical literature source for sublingual Midazolam being equivalent to I.V. the few I've seen say it's far lower but higher than oral bioavailibility? If it's too bitter to take sublingually I might try making a nasal.spray solution as that's a higher BA too but more importantly it's a more consistent BA for the drug and thus more predictable in the effect it will provide me.


EDIT: I just tried to sublingual it and it tasted like bitter ass almost as bad as alprazolam more or less... so I decided to take roughly 7.5mg dose orally. I also took a 0.25mg clonazepam 14 hours ago as I due everyday and depending on how strong and how long this Midazolam lasts I might be taking my 5 Nitrazepam tablet at night depending on how the experience is.
 
Last edited:
There is a big difference betweeen SL midazolam that is formulated specifically for that use and tablets filled with bunch of binders that are could be clogging sublingual absorption. For SL use midazolam usually comes in liquid form that has no binders and contains some ingredient that will help with absorption. If you are able to do an extraction of midazolam from tablets and get rid of binders than that might work. But as mentioned if you want to truly increase absorption intranasal is the way to go. As this study shows :

"As compared with intravenous application, the bioavailability of the nasal form is approximately 72.5% to 83%."

But they were using similar preparation to NAYZILAM (midazolam nasal spray) not crushed Versed/Dormicum. List of ingredients for this nasal spray can be found here and it contains:

"What are the ingredients in NAYZILAM?

Active ingredient: midazolam

Inactive ingredients: ethanol, PEG-6 methyl ether, polyethylene glycol 400, propylene glycol and purified water"

But for all people reading this - if you don't have a proper health reasons for using benzodiazepines it is just not worth it. This are potent anti-seizure drugs that act on GABA which is THE primary inhibitory neurotransmitter ( with glutamate being primary excitatory one) that is located all over the body and disruption of GABAergic system will lead to dependence which you don't want to even read about. Best anology is the car one - in which GABA are the brakes and glutamate is the gas pedal. Once disturbed it takes a lot of fine tuning for a body to achieve homeostasis - and the process is brutal. It is widely accepted that stopping long benzodiazepine addiction (dependency) ond the withdrawal that comes with it is more challenging thsn stopping (true) heroin addiction - because if GABA is fucked up all systems are fucked up. It is just not worth it unless one suffers from seizures, heavy anxiety that is truly naking life not worth living and other disorders for which benxodiazepines are truly valuable medications. Thread lightly if you must but please have respect for this class of drugs and avoid it if you can...

Take care people!
 
Last edited:
Well I consumed 12.5mg orally of Midazolam roughly which was somehow WAY weaker than taking only 10mg of Nitrazepam for me which I take 5mg daily of that and 0.25mg clonazepam so it doesn't make sense that this didn't even provide any slight anti-anxiety feeling forget any potential hypnotic effect for insomnia.


If I did not know the tablets were legit I would think I got fake tablets so... I'm wondering if maybe I've messed up my tolerance from using 4-6mg Clonazepam daily for like 4 years give or take a year. I also lowered my benzo dose dangerously quick to the dose I mentioned above and have been on that dose for roughly 2 years straight now without increasing my dose until now that's only reason I'm far more skeptical that it's tolerance especially. Except I did use 20mg Nitrazepam a few months back in May I think but it was far stronger of an effect too which makes me wonder if I'm simply poorly absorbing Midazolam via oral ROA or if I'm just not taking enough of it.


Also I thought sublingual is better than nasal spray solution midazolam but if it makes the nasty tasting drug to have less contact time with my taste buds I'm down for it either way lol. I just do not know how to even begin going about making a proper nasal spray solution as I haven't even made 1 for cocaine before which should be infinitely more simple than having to extract the midazolam somehow reducing the binders and fillers amount before making it into a nasal spray solution or sublingual solution of some type. Maybe mixing the sublingual solution with tang powder like they do methadone might help mask the taste of it or would that mess with the absorption even if it's liquid form?
 
Wish I could help you but I never tried to turn tablets into purified solution. Just wanted to emphasise that there is a big difference between taking tablets vs solution made for SL or nasal usage. Hope you find the relief you need.
 
Here's a link to a benzo equivalent calculator....https://clincalc.com/Benzodiazepine/
 
I have no clue how to make a solution. I just take mine orally or sublingual.
 
Since I was prescribed midazolam today I will share my experience in a week. But I have long history of benzo use and unfortunately a tolerance that goes with it. ~ 5 yars ago i was prescribed 7,5 mg lorazepam with 30mg of midazolam. Few months later i was put on 6mg SR Xanax (2mg tid) + 20mg of diazepam and 30mg of midazolam in the evening. But as my insomnia was really bad and I had to wake up fot work I took (not at once, but in the span of 3 hours) 75mg of midazolam and yet still went to work withouth a minute of sleep. Such a horrible experince. I am trying to get through that I am jot the best test subject due to high tolerance. But I hope that 15mg of SL midazolam will give me at least 4-5 hours of sleep. Will update my trsting.
 
But baesed on the studies that I bumped on in 30 seconds there is an agreement that even Roche Dormicum tablets are worth taking sublingualy.

Comparative study of sublingual midazolam with oral midazolam for premedication in pediatric anesthesia
SL Dormicum tablet is 2½ times more sedating than oral midazolam.

Also this study

Premedication with midazolam is more effective by the sublingual than oral route
Midazolam (Dormicum) 7.5 mg sublingual is a more effective pre-anaesthetic sedative than by the oral route.

Off to the benzo dreamland (I hope).
 
After a week or so I concluded that I do not feel noticeable difference between midazolam 15mg oral vs
sublingual. My tolerance to benzos is unfortunately just too fucked up... So I decided to take it 50/50. I brake the pill in half, drink one 1/2 and SL other 1/2. It certainly helped my sleep even though I still have a tendency to wake up too early.

In conclusion my experiment is inconclusive.
 
Well @MedicinalUser247 although I don't know your medical records probably you know how short life midazolam has and it certainly blows a short but strong punch to GABA-A receptor. I was long time forced upon it due to being wrongly diagnosed and that might be the only reason, besides hardcore insomnia, why it was prescribed to me now. If one doesn't need it for seizure disorder or eventualy 7-10 days if something traumatic happened to the person it is not prescribed anymore. Doctors rather give low dose (25-50mg) of quetiapine (Seroquel) for hardcore insomnia and midazolam is mostly used before surgery for calming people down and during surgery by an anesthesiologist. It hits hard, duration is short and if one uses it for anything else besides achieving sleep it will raise overall tolerance pretty rapidly. I am not the one to preach cause I am of a stance that adult person should be able to decide what substances are suitable and am against whole notion of making people juvenile by restricting them drugs. I would prefer that people can have diamorphine if they choose to after being informed about risks and benefits it brings. But for me midazolam is the benzo of the last resort when all else fails. Although it comes miles before quetiapine or any other neuroleptic. Maybe I would have a different equation if I was not on high doses of benzodiazepines for a very long time...but even then I wouldn't use midazolam for daytime anxiety of anything else that isn't sleep. But I would not keep it away from other adults either. I am rambling but the gist of it all is - midazolam is not a good choice for daytime benzo or if one has low to medium tolerance. But that's just my opinion based on too long of an experience with various benzodiazepines. Take care you all!
 
Well when I mean for any potential anxiety inducing situations I'd might want to use Midazolam for is maybe if I ever slightly overuse a stimulant or a psychedelic drug but even them I'd probably opt for something else.


So do you think it.l is my tolerance or that it's not my tolerance?
 
Psycho_Logic said:
"As compared with intravenous application, the bioavailability of the nasal form is approximately 72.5% to 83%."

But they were using similar preparation to NAYZILAM (midazolam nasal spray) not crushed Versed/Dormicum. List of ingredients for this nasal spray can be found here and it contains:

"What are the ingredients in NAYZILAM?

Active ingredient: midazolam

Inactive ingredients: ethanol, PEG-6 methyl ether, polyethylene glycol 400, propylene glycol and purified water"
Click to expand...
Sounds like a nasty spray they made, had on alike only it used IsoPropylAlcohol for its devestating spike.

to my surprise a other generic form doesn t use any type of Acohol or nasal congesting ingredient.

So no sting, no clogging. Without knowing the excact science,
their spray was based upon malto-dextrin and worked like a charm.
Didn t hurt and no clogging especially important for its intended use.
Epileptic/ Seizures.
 
You must log in or register to reply here.
Top