Mental Health Wellbutrin - same problems as other stimulants?

Sure

Greenlighter
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Jul 8, 2016
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Wellbutrin is a stimulant.
 
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I wouldn't recommend Wellbutrin to anyone. It messed up my sleep patterns, possibly permanently. I can't sleep more than an hour at a time now without waking up... and I stopped taking it 4 years ago.
 
Maybe it's a stimulant in purely technical terms. But as for its effects, it's energizing, but not really like a classic stimulant is. This is a situation in which you'd need to look beyond the basic way it works to understand.

Wellbutrin has a reputation for creating less hypo/mania than basically any other antidepressant.

Wellbutrin works fairly selectively on nor/epinephrine at doses up to 200mg. Psychosis is mostly too much dopaminergic activity. Amphetamine is much much much more dopaminergic than Wellbutrin. That's why amphetamine (including Vyvanse) is a Schedule II controlled substance, while Wellbutrin isn't a controlled substance.

This is kind of a classic case of self-prescription based on reductive knowledge.

Give it a shot. If he comes up with psychosis again (very doubtful) then take him off of it.

The two are related structurally, but amphetamine and wellbutrin have very different effects.
 
The problem with just "giving it a shot" is that the patient is not reliable in reporting side effects.
 
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It can be difficult to determine if someone is psychotic or not. That said, his psychiatrist should be able to tell, especially considering that you now know how he acts when he's psychotic. Psychosis can come on fast, but I would imagine that you and his psychiatrist would be able to sense early warning signs.

It's really not likely that he'll become psychotic from Wellbutrin.

People read up a little on the drugs they or close one is taking, then jump to conclusions about it basd on incomplete knowledge. That's what I meant.

Did you ask why the psychiatrist wanted to give him Wellbutrin?
 
The new team suggested trying Wellbutrin because the SSRI types don't seem to be helping the depression.
 
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I don't just read a little on the internet and jump to conclusions. I try to be as informed as possible, read scholarly articles, examine chemistry, cross reference several sources.

If this were true, you would know that Wellbutrin and Vyvanse are quite different in effects, and that Wellbutrin is better termed an antidepressant than a stimulant. It's not even uncommon knowledge.

Wellbutrin is often prescribed off-label for ADHD (because it's a stimulant).

...

Eventually he reported that the psychosis was gone. Either the psychosis went away because of the antipsychotics or simply because the Vyvanse was discontinued.

So he knows what it feels like, and that he should report it. Didn't you say something different? I don't see the issue here in trying Wellbutrin.
 
If this were true, you would know that Wellbutrin and Vyvanse are quite different in effects, and that Wellbutrin is better termed an antidepressant than a stimulant. It's not even uncommon knowledge.

Never suggested they were the same thing. But it doesn't matter what the drug rep calls it; anyone can read up on the chemistry.


So he knows what it feels like, and that he should report it. Didn't you say something different? I don't see the issue here in trying Wellbutrin.


Wow. I'm not trying to argue. No he doesn't reliably report.
 
Maybe just go with good old Ritalin, or Biphentin/Concerta (extended release formulas, although I think we only have Biphentin in Canada, it's easier to abuse because its time-release beads in a gelcap, one can crush it all with a mortar and pestle while abusing Concerta is almost impossible, unless of course, you take the 54mg pills but I don't think your son would be scripted 54mg Concertas or if Canadian, the damn Biphentins go up to 80mg, I actually have a couple 80mg Biphentins in a little box with a bunch of stuff I don't intend on using, 2 80's and 5 60's (there is no 70's). Which reminded me, Vyvanse doses stop at 50mg here, no 70mg ones.

But yeah, good old regular twice a day (2x5mg...I was put on 2x10mg right off the bat and it didn't agree with weed at all so I ditched the script way back then). Ritalin might be a stimulant but its pretty mild, especially at that dose when eaten. But you can go with that weird stuff nobody likes I forgot the name of, for ADD, or Tenex and if you have an extended release form of Tenex, like we do here (Intinuvir XR), they're totally the opposite of stimulants, it can be used alone for ADD/ADHD, like Clonidine can,, Tenex is related to Clonidine, they tend to work best for ADD:PI.
 
Hey Sure,

Sorry about that.

I have to hold my position, though. If you look at some other details, it's probably a little more clear.

Wellbutrin can cause psychosis, but I believe it has a much lesser chance than Vyvanse at causing it.

Again, I got a little too surely. My apologies.
 
No worries Ho-Chi-Minh. Thank you for your input. Your discussion of Wellbutrin's effect on nor/epinephrine versus dopamine was useful for my research and helpful to my understanding.
 
The new team suggested trying Wellbutrin because the SSRI types don't seem to be helping the depression.

That's a perfectly legit reason to try Bupropion. SSRI's/SNRI's don't work for alot of people and in my case since i have Bipolar disorder it's the least likely Anti-Depressant to cause Mania or mixed states. The one and only time i took a SNRI was when i took Effexor before i was diagnosed Bipolar and it drove me completely Manic and made my life hell while i was taking it and even though i was only taking it maybe 6 weeks the withdrawals where perhaps the worst i have experienced from any drug. It even beat out going basically cold turkey off 6mg's of Clonazepam a day.

Wellbutrin is a Stimulating Anti-Depressant as it's a Norepinephrine and Dopamine reuptake inhibitor but it's not a stimulant like say Dextroamphetamine as Amphetamines are Dopamine Agonists not reuptake inhibitors. Wellbutrin is more like Methylphenidate aka Ritalin then Amphetamines but it's effects are not even very similar to that. In my experience it takes a few days for the mood lifting and slight stimulant effects to kick in while it takes about a week at 300mg's a day for the full Anti-Depressant effects to kick in. Of course everyone is different and for some they notice the mood brightening effects almost right away while with others it may take a good 2 weeks or longer just like SSRI's. Out of all the Anti-Depressants i have taken not only is Wellbutrin one of if not the most effective Anti-Depressant i have tried (especially for Seasonal Affective Disorder) but it has about the mildest side effects out of all of them and unlike SSRI's/SNRI's Bupropion does not cause any real withdrawal symptoms except a return of Depression.

As for it causing psychosis yes it can the same as any Anti-depressant or just about any stimulant for that matter. But Amphetamines are much more likely to cause psychosis then Wellbutrin is. I am diagnosed as having Bipolar with psychotic features and i have never experienced any type of psychosis because of wellbutrin. I believe SSRI's and SNRI's are much more likely to cause psychosis then Wellbutrin as well.
 
Welbutrin was somewhat effective for my depression/lethargy..i felt more activated on it an hour after my first dosage..yet my anxiety also went up along with blood pressure..the good effects seemed to disappear over time but the negatives stayed so i got off..
 
Hi belfort, do you mind me asking what was your approximate age range when you tried Wellbutrin?
 
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