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wellbutrin and psychedelics

2c-b should be ok.
MXE is a little more experimental but I can't see any interactions here - take it slow.
 
Bupropion is an NDRI and nAChR antagonist (and CYP2D6 inhibitor1), it is contraindicated with DXM (SNRI, CYP2D6 substrate), which has been reported to feel unpleasant in combination. 4-MeO-PCP has some NE activity too, but it's a lot weaker. PCP and Ibogaine might interact as well (NE, DA, nAChR).

Should be perfectly fine with serotonergic psychedelics (though a few people report their trips, or ability to trip being negatively affected), and a cursory look shows no problems with MXE.

Oh, and don't take it with MAOIs.
 
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^ Aw shit that explains why 200mg of DXM made me nauseous for two days last month.

Didn't think hard enough about it, and overlooked metabolic interactions.
 
I've been taking Wellbutrin for 10 months and have had a few experiences. I'd used none of these drugs before taking Wellbutrin.
  • I used up to 50mg MXE while at 150mg Wellbutrin XL, everything seemed normal, although a few times I got headaches/felt nauseous. This may have been due to dehydration.
  • I tried 1mg 25i-NBOME, also while at 150 mg Wellbutrin XL, and had a very bad time, but I had also taken a 5 Hour Energy beforehand (this was a very bad idea). Very bad panic attack with sweating and rapid heartbeat. Took klonopin and that seemed to make things better. I later tried 25i-NBOME again, at 500µg, without the 5 Hour Energy, and didn't notice many effects (psychedelic or physical).
  • I used 5-MeO-MiPT a few times. The first time I took 12mg and was on 150 mg Wellbutrin XL and I'd been drinking. There were no bad effects, no anxiety or anything. The second time I took 8mg while I was on 300 mg Wellbutrin XL and nearly had a panic attack while coming up - took a small dose of Xanax to calm down. My heart rate wasn't too high (
  • I took shrooms twice while on 150mg Wellbutrin XL. Not sure of dosage but neither were that strong. Both times were anxiety free, but both times I felt a weird pain in my neck that felt cardiovascular-related. No other physical side effects.
  • I used 6-APB too many times, doses ranging from 65 to 120 mg, while on both 150 mg and 300 mg Wellbutrin XL. I had physical side effects that are in line with other people's experiences - elevated heart rate, more thirst, jaw clenching, etc. (I have some complaints about this drug but they are not related to Wellbutrin.)

In general I've found that it's easier to get dehydrated while on Wellbutrin, so be sure to drink an appropriate amount of water.
 
thanks for the info. havent had any problems yet... a good antidepressant that doesnt have many side effects and interactions seems too good to be true
 
I'd be interested to hear how you would do without the 5 hour energy and the same dose or more of 25i nbome.

I'm taking 300mg for ADD, and I like it, but I havent had any of my 5 meo mipt or my 25i nbome since I started wellbutrin. My drive to consume drugs and alcohol has much lessened since, I have actually gone a few weekends without beer! But I am also broke too and beer costs money, of which I have not a lot of right now, but still I don't crave it much (on weekends)

There is not much on the net about this.
I think that some of your symptoms seem like normal negative attributes for these drugs, I know 5 meo mipt can give me anxiety on the come up, and so can 25i nbome, just due to the excitement I guess?
I wonder if when you took the 500mg of 25i nbome and felt nothing and had no 5 hour energy may mean you'll be fine at a higher dose again next time?
 
I've been thinking about psychedelics and Wellbutrin lately, and I think I will stick to precisely measured light doses for as long as I'm on the drug, even when around experienced people and even when benzos or antipsychotics are available to reduce anxiety or end the trip.

PowerFarts said:
I think that some of your symptoms seem like normal negative attributes for these drugs, I know 5 meo mipt can give me anxiety on the come up, and so can 25i nbome, just due to the excitement I guess?
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On 5-MeO-MiPT it might have been regular anxiety that I would have gotten even if I hadn't taken Wellbutrin, yes.

I wonder if 25i may be unsafe with stimulants (it doesn't seem to be particularly safe to begin with). This post explains some of the physical reactions that I felt. The same day I tried 25i-NBOMe I had taken Adderall XR in the morning. Wellbutrin is pretty much a stimulant, so there could be danger there.

This trip report on 2CB, shrooms, and Wellbutrin indicates minor physical side effects.

In general Wellbutrin increases anxiety, so it can make any bad trip worse. It also lowers seizure threshold so there's risk there too. Tripping alone seems to be a lot riskier.

PowerFarts said:
I wonder if when you took the 500mg of 25i nbome and felt nothing and had no 5 hour energy may mean you'll be fine at a higher dose again next time?
Click to expand...
500mg is an extremely dangerous dose! It doesn't seem right that 500µg (micrograms) would have no effect on me given how powerful 1mg was. I wonder if maybe I only took 250µg, or if it was a bad tab.

I'm not sure if I want to try 25i again.
 
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500mg's, I meant 500µg, that would be just too much!
I have taken 2.5mg's before the wellbutrin and had a good time.
As a comparison, I would like to know if you have taken any decent dose on the same day that you have not taken wellbutrin, or adderall.
Thanks for your post.
 
I'd never taken 25i before that time. I might not be able to tolerate it at all in moderate to large doses.

I've been taking Wellbutrin XL 300mg for a while, including today, and earlier I tried a dose of 10mg 2C-B. I was in a good mindset before dosing, with a low heart rate, but right after dosing I started to feel anxious and my heart rate jumped to 100, so I took .5mg Xanax. Overall it was a slightly dysphoric experience. The psychedelic effects expected from a low dose were mostly there, but the physical effects were more than I would have liked and much more than I'd experienced on a higher dose before Wellbutrin. Sore neck (vasoconstriction?), tense muscles, and a bit of body load. I've definitely felt the feeling in my neck before when combining psychs and Wellbutrin. Blood pressure normal (125/79) and heart rate 105 a few minutes after taking a walk, 90 lying on the couch watching TV. Didn't feel any real anxiety during the trip, but I did take the Xanax beforehand. My mood actually got worse as I was coming up, but I'm not sure why & don't think it could be related Wellbutrin.

I think I was right to stick with the low dose. I might have had a panic attack at 20mg. I'm not sure if I'll repeat this experiment for as long as I'm on Wellbutrin - maybe in a different setting. Compared to my positive experiences with shrooms and Wellbutrin, the psychedelic effects were not enough to make up for the physical side effects (but might have been if the drug had elevated my mood).

I think Wellbutrin is likely to increase physical side effects on psychedelics, but since some report not having these problems, I may be more susceptible to them. That, combined with increased anxiety while on Wellbutrin, makes me think I should avoid psychedelics for now.

EDIT: What would the effect of skipping a Wellbutrin dose or two be? I've stopped for days at a time before, back when I was on 150mg XL, and the withdrawal is minimal. Half-life data: Wellbutrin itself: 12–30 hours, each of its metabolites:15–25, 23–43 and 24–50 hours. Clearance: 4–12 days. Could skipping Wellbutrin on Friday and Saturday morning be enough to make Saturday night a little safer for psychedelics?
 
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a dream said:
I think Wellbutrin is likely to increase physical side effects on psychedelics, but since some report not having these problems, I may be more susceptible to them. That, combined with increased anxiety while on Wellbutrin, makes me think I should avoid psychedelics for now.
Click to expand...

I have found wellbutrin to give me less anxiety, I feel or when I look back before wellburin, life in general was giving me anxiety.

Thanks for your input and your honest opinion.
 
OK, I consumed 10mg of 5-meo-mipt, I am taking wellbutrin 300mg/day for ADD.
Seems 10mg is just as enjoyable as a 25mg trip, at least since starting Wellbutrin.
And I didn't have as much dysphoria at this lower dose, but 25mg was pretty good pre-wellbutrin.

After I took it I smoked a joint, grabbed a beer and went out and mowed the lawn with the reel mower, took a few strokes of the thing each few feet because after all that rain the weeds were tall and out of control, despite being choked out by all that pesky grass that I can't get rid of.
Well that was fun, then it started to rain and I did some happy lucky fun good time strokes indoors, that was a SWELL time for sure (thanks 5-meo-mipt :) ).

Then I went to bed and my mind was wired and I layed there unable to sleep for a few hours, lack of sleep today, but I pulled through.

Now the 25i nbome.....
 
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