Voacanga africana - ingredients and uses.

[izo]

next plant profile, also rather well known:

Voacanga africana - Wikipedia

en.wikipedia.org

Voacanga is a shrub native to Africa that belongs to the dogbane family. The seeds and bark of Voacanga africana have hallucinogenic and stimulant effects.
The bark is used by locals as a hunting drug. In addition, this medicinal plant is considered an extremely potent aphrodisiac in Africa.
The seeds are primarily used by shamans and sorcerers to create visions. In Gabon, a different way is used to get naturally intoxicated. It is the species Voacange bracteata that is used as a marijuana substitute in Gabon.

alkaloids on wiki:

Voacangine - Wikipedia

en.wikipedia.org

Ibogaine - Wikipedia

en.wikipedia.org

Voacamine - Wikipedia

en.wikipedia.org

 

[izo]

from rätsch:

Voacanga spp. (Apocynaceae) - Voacangus shrub
The bark and seeds of the African dogbane plant Voacanga africana STAPF.3jy contain up to 10% indole alkaloids
of the iboga type (cf. Tabernanthe iboga, ibogain) and are said to be stimulating and hallucinogenic (BISSET 1985b, OLIVERBEYER
1982:8). Voacamine is the main alkaloid.
The seeds are said to be used by African sorcerers to produce
used visions. In West Africa, the bark is used as a hunting drug and stimulant (SCHULDES 1995: 77*). It applies
also as a potent aphrodisiac. The bark of Voacanga bracteata STAPF. used in Gabon to indicate "high".
(probably as a marijuana substitute; cf. Cannabis indica). It contains 2.46% alkaloids (Voacamine, Voacamine-Noxide,
20-epi-Voacorin, Voacangin), which are closely related to the ingredients of Tabernanthe iboga, but apparently
only have a slightly dampening effect (DE SMET 1996: 145*, PUISEux et al. 1965).
Likewise, Voacanga dregei E.
MEY have a hallucinogenic effect (SCHULTES and HOFMANN 1980: 366*). The seeds of
Voacanga grandiflora (MIQ.) ROLFE are taken by sorcerers in West Africa for visionary purposes. Unfortunately they are
Details are not yet known, as the magician's knowledge is kept secret.

 

[izo]

1997 - Ibogaine and a Total Alkaloidal Extract of Voacanga africana Modulate Neuronal Excitability and Synaptic Transmission in the Rat Parabrachial Nucleus In Vitro

ABSTRACT: Ibogaine is a natural alkaloid of Voacanga africana
that is effective in the treatment of withdrawal symptoms and
craving in drug addicts. As the synaptic and cellular basis of
ibogaine’s actions are not well understood, this study tested the
hypothesis that ibogaine and Voacanga africana extract modulate
neuronal excitability and synaptic transmission in the
parabrachial nucleus using the nystatin perforated patch-recording
technique. Ibogaine and Voacanga africana extract
dose dependently, reversibly, and consistently attenuate
evoked excitatory synaptic currents recorded in parabrachial
neurons. The ED50 of ibogaine’s effect is 5 mM, while that of
Voacanga africana extract is 170 mg/ml. At higher concentrations,
ibogaine and Voacanga africana extract induce inward
currents or depolarization that are accompanied by increases in
evoked and spontaneous firing rate. The depolarization or inward
current is also accompanied by an increase in input resistance
and reverses polarity around 0 mV. The depolarization
and synaptic depression were blocked by the dopamine receptor
antagonist haloperidol. These results indicate that ibogaine
and Voacanga africana extract 1) depolarize parabrachial neurons
with increased excitability and firing rate; 2) depress non-
NMDA receptor-mediated fast synaptic transmission; 3) involve
dopamine receptor activation in their actions. These results
further reveal that the Voacanga africana extract has one-hundredth
the activity of ibogaine in depressing synaptic responses.
Thus, ibogaine and Voacanga africana extract may
produce their central effects by altering dopaminergic and glutamatergic
processes.

 

[izo]

2000 - Anti-ulcer actions of the bark methanol extract of Voacanga africana in different experimental ulcer models in rats

Abstract
The antiulcerogenic effects of the bark methanol extract of Voacanga africana were studied using various
experimental ulcer models in rats. The effects of the extract on the volume of gastric juice, gastric pH, acid output,
mucus production and peptic activity were recorded, as well as the preventive action against lesions caused by
HCl:ethanol and indomethacin. Oral administration of the extract (500–750 mg:kg) inhibited the formation of gastric
lesions induced by HCl:ethanol (40–63% inhibition). The inhibitory effect against HCl:ethanol was significantly
(PB0.01) suppressed by pre-treatment of the rats with indomethacin (30 mg:kg, i.p.). The extract significantly
reduced gastric lesion formation in pylorus ligated rats, but this was not associated with an increase in gastric mucus
production or with a reduction in acid content, volume of gastric secretion or pepsin activity of the gastric juice.

 

[izo]

2002 - Extraction Studies of Tabernanthe Iboga and Voacanga Africana

The root bark of Tabernanthe iboga contains ibogaine as its predominant alkaloid and has been an important
source ofit. Ibogaine is used experimentally to interrupt drug addiction and allow therapeutic intervention,
but is currently unaffordable to doctors in less economically developed countries. To meet this need,
an extraction ofalkaloids from T. iboga root bark was optimized and simplified to use only diluted vinegar
and ammonia, and was successfully applied to related alkaloids from Voacanga africana bark also. The
alkaloids were converted to their hydrochlorides and purified, and the minor alkaloids were recovered.

 

[izo]

2009 - Chemical and DNA Analyses for the Products of a Psychoactive Plant, Voacanga Africana

Abstract
Voacanga africana (Apocynaceae) is a small tropical African tree. The root bark and seeds of this tree contain a number of alkaloids, including ibogaine (a hallucinogenic/aphrodisiac compound in bark), tabersonine (a major constituteent of seeds) and other voacanga alkaloids, traditionally used in Africa for religious purposes. Recently, some kinds of products containing this plant (root bark and seeds) have been distributed in the drug market in expectation of its hallucinogenic/aphrodisiac effects. There has been no report that has discussed quantitative analyses of these alkaloids in the products and their botanical origins. In this study, to investigate the trend of such a non-controlled psychotropic plant of abuse, a simultaneous analytical method was developed using LC/MS for the voacanga alkaloids including ibogaine and tabersonine in the commercial products of V. africana. Moreover, the botanical origins of these products were investigated by DNA analyses. As a result of the LC/MS analyses, the products were classified into two chemical types; an ibogaine-type and a tabersonine-type. The samples of the ibogaine-type contain ibogaine (0.05-0.6%) and other voacanga alkaloids; voacamine, voacamidine and voacangine, while those of the tabersonine-type mainly contain tabersonine (0.6-1.6%). The sequence analyses of chloroplast DNA, trnL-F region suggested that most of the products were derived from V. africana or closely related plants. They were classified into four genotypes based on nucleotide sequence of the trnL-F IGS region. The proposed methods of chemical and DNA analyses would be useful for investigating the trend in the distribution of the products of V. africana.

 

[izo]

2019 - Extraction and Conversion Studies of the Antiaddictive Alkaloids Coronaridine, Ibogamine, Voacangine, and Ibogaine

Several species from the Apocynaceae family, such as Tabernanthe iboga, Voacanga africana, and many
Tabernaemontana species, produce ibogan type alkaloids, some of which present antiaddictive properties. In this
study, we used gas chromatography/mass spectrometry (GC/MS) to examine the efficiency of methanol, acetone,
ethyl acetate, dichloromethane, chloroform, and hydrochloric acid in extracting the antiaddictive compounds
coronaridine, ibogamine, voacangine, and ibogaine (altogether the CIVI-complex) from the root barks of
Tabernaemontana alba and Tabernaemontana arborea. These Mexican species have recently shown great
potential as alternative natural sources of the aforementioned substances. Methanol proved to be the most
suitable solvent. Furthermore, the crude methanolic extracts could be engaged in a one-step demethoxycarbonylation
process that converted coronaridine and voacangine directly into its non-carboxylic counterparts
ibogamine and ibogaine, respectively, without the intermediacy of their carboxylic acids. The established
protocol straightforwardly simplifies the alkaloid mixture from four to two majority compounds. In summary, our
findings facilitate and improve both the qualitative and quantitative analysis of CIVI-complex-containing plant
material, as well as outlining a viable method for the bulk production of these scientifically and pharmaceutically
important substances from Mexican Tabernaemontana species.

 

[izo]

2020 - Quantitative Evaluation of a Mexican and a Ghanaian Tabernaemontana Species as Alternatives to Voacanga africana

In continuation of our efforts to provide quantitative information on antiaddictive ibogan type alkaloid-producing
Tabernaemontana species, we used gas chromatography-mass spectrometry (GC-MS) to compare the alkaloid profiles of the
barks and/or leaves of one Mexican and one African species – T. arborea and T. crassa, respectively – with the primary
sources of commercially available semisynthetic ibogaine, Voacanga africana root and stem bark. The qualitative and
quantitative similarities between T. arborea and V. africana barks consolidate previous reports regarding the potential of the
former as a promising alternative source of voacangine and ibogaine. The results also suggest that T. crassa could be used
to produce conopharyngine and ibogaline, two compounds with the same basic skeletal structure and possibly similar
antiaddictive properties as ibogaine.

 

[izo]

1997 - Ibogaine and a Total Alkaloidal Extract of Voacanga africana Modulate Neuronal Excitability and Synaptic Transmission in the Rat Parabrachial Nucleus In Vitro.pdf
2000 - Anti-ulcer actions of the bark methanol extract of Voacanga africana in different experimental ulcer models in rats.pdf
2002 - Extraction Studies of Tabernanthe Iboga and Voacanga Africana.pdf
2009 - Chemical and DNA Analyses for the Products of a Psychoactive Plant, Voacanga Africana.pdf
2019 - Extraction and Conversion Studies of the Antiaddictive Alkaloids Coronaridine, Ibogamine, Voacangine, and Ibogaine .pdf
2020 - Pharmacology of Herbal Sexual Enhancers A Review of Psychiatric and Neurological Adverse Effects.pdf
2020 - Quantitative Evaluation of a Mexican and a Ghanaian Tabernaemontana Species as Alternatives to Voacanga africana.pdf

 

[izo]

tested the 100x extract already last year, had a nice evening on it along with some bdo. nice tryptamine like feeling. it is a whole plant extract.