Opioids Very strange -- has anyone ever heard anything like this?

[incaseofaburglar]

Once off opiates, your brain chemistry WILL return to a natural state. But it takes time. Sometimes, a lot of time. Your receptors, your GDNF, your neurotransmitters, the way your endorphins, dopamine and serotonin works, etc., etc....all affected by continuous opiate use.

Suboxone has a very nasty long term effect on the receptors, yes. But it is not permanent. With time, exercise, taking care of yourself...your brain will heal. Ibogaine is a quick way to reset the brain chemistry. People don't talk about this aspect very much, most people focus on it's ability to interrupt opiate withdrawal symptoms (which is extremely notable!), however, in very simple terms the brain "reset", is quite phenomenal. Suboxone directly to ibogaine is ineffective, due to suboxone's ability to store itself in one's fat cells. However, I got off suboxone with ibogaine (which is why I am talking so much about it). I switched to a short acting opiate for a duration of time and then went through ibogaine treatment. I came out the other side with what felt like a pre-addicted brain. I was happy. My receptors did not crave opiates. My endorphins worked properly. So I would not say that suboxone has a permanent effect on the brain. The brain is constantly changing. Whether you get off through tapering and let the brain heal itself over the course of a couple of years - or you pick up natural supplements, yoga, etc. to speed up the process - or you do something like ibogaine -- your receptors can and will heal! Think positively. Suboxone is a nasty thing, a hard thing to get over, but it is definitely more than possible!

 

[f33lg00d]

Ibogaine doesnt "reset" brain chemistry. A good trip can help work out psychological problems though, and therefore making people come out happier w less desire to use; but in no way will it return your endorphins and monoamines levels to normal before drug abuse levels instantly. Its not that your receptors didnt crave endorpins/opioid, its that your consciousness didnt.

It lessens withdrawals because it (including its metabolites) is an opioid and nmda antagonist, among other methods of action, with a long half life. So essentially its like a short taper, the nmda antagonism helps this to as drugs with nmda antagonism lessen withdrawal symptoms (ie dxm, ketamine, pcp).

 

[incaseofaburglar]

Ibogaine doesnt "reset" brain chemistry. A good trip can help work out psychological problems though, and therefore making people come out happier w less desire to use; but in no way will it return your endorphins and monoamines levels to normal before drug abuse levels instantly. Its not that your receptors didnt crave endorpins/opioid, its that your consciousness didnt.

It lessens withdrawals because it (including its metabolites) is an opioid and nmda antagonist, among other methods of action, with a long half life. So essentially its like a short taper, the nmda antagonism helps this to as drugs with nmda antagonism lessen withdrawal symptoms (ie dxm, ketamine, pcp).

Actually, ibogaine eliminates withdrawals, because it's metabolite, nor-ibogaine is an agonist at opioid receptor sites, particularly at mu and kappa. It does interact with NMDA for long periods of time along with dopamine, serotonin, nicotonic channels, amongst other (etc., etc.). By agonizing mu, noradrenaline is kept in check. Opiate addicts are receiving a pronounced level of noradrenaline. Chills, tremors, etc. are onset when noradrenaline is offset.

Ibogaine is a weak reuptake inhibitor at dopamine and serotonin (amongst others), it blockades the nicotinic channel and yes, antagonizes NMDA. It absolutely reprograms opiate signaling in the brain along with other neurotransmitter systems back to a state of homeostasis. It doesn't do this instantly (no one said it did), this occurs over a period of about 72 hours, usually once the person in treatment has been able to sleep for a bit. It absolutely brings the brain back to a neurobiological equilibrium. Furthermore, it is releasing so many neurotransmitters, the body is forced to start the production of so many of our "well being" chemicals and neurotransmitters.

Stating ibogaine can not bring the brain back to an equilibrium is like saying you can build a castle out of legos, but you could never take it apart again and put the pieces back in the box... ... ...

 

[wezface]

what does it mean for opiates to have "changed my brain chemistry?" actually did not know something like this was possible. obviously it changes brain chemistry but i did not know they could do anything long-term and permanent.

for anyone interested, in the sake of science, i am going to try a previous dose of pharms that got me high. even though i am fairly sure the pharms won't work either. I'm not trying to be stubborn, just logical; as I know what information i can trust/discard at this point. also, i would be shocked beyond belief if it was a tolerance problem.

like i said, i have tried a few different batches of heron from a few different dealers that I have always had good experiences with, not discounting the fact that my friends love the product.

This has happened to me. Read up on PAWS (post acute withdrawal syndrome) and you'll find some of the answers you're looking for.

 

[incaseofaburglar]

This has happened to me. Read up on PAWS (post acute withdrawal syndrome) and you'll find some of the answers you're looking for.

Yes. Definitely. PAWS is no fun and very, very real.

 

[wezface]

They say it lasts for up to two years but, quite honestly, I'm pretty sure I have a permanent case. When I take opiates of any sort my nerve pain goes away, my fatigue goes away, my depression improves. I've been diagnosed with fibromyalgia but I am pretty certain it's just indefinite PAWS, as I used very heavily for a very long time.