I haven't really saw many people talk about this, but I know some people had great results with varinostat as a HDAC inhibitor for fear extinction, but I was thinking of using valproate as it was used in studies for fear extinction, but how could it be used to reverse epigentic changes?Because people advised using varinostat about once a week as it can arrest cell cycles, but valpoate does the same if used daily and from what I have read and it has to build up in the system!If it is used at least 1000mg in one single dose, would it spike blood levels enough for it to work?And while on valproate, doing exposure therapy, maybe adding propranolol too if anxiety is too bad!Should exposure therapy be done only under these meds or even in the days where nothing is taken?
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BDD Moderators: Keif’ Richards | negrogesic
Valproate/valproic acid as a HDAC inhibitor for fear extinction
- Thread starter Rugarul7
- Start date
This is very specific question where most people probably don't have experience about. But you could maybe ask neuropharmacology mod if they considered it possible this got more attention in that subforum.
ChemicallyEnhanced
Bluelighter
I'm on Valproate (seizures) but have NO IDEA what your post even means, tbh. I think it's not getting many replies, because it's gonna take someone with a lot of niche, specific knowledge to answer you.