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Using the body to make drugs!

So will a sample of urine from a person who has recently used codeine yield a sufficient amount of morphine?

More input please?
 
This sounds like my have the constructs of a good idea. See if you can strike a deal with your local sewage plant. There must be all sorts of goodies in there :P
 
So will a sample of urine from a person who has recently used codeine yield a sufficient amount of morphine?
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If you use grapefruit juice at the same time (to prevent any N-demethylation), the final products of metabolism of codeine will be nearly all morphine and morphine-6-glucuronate, so by adding together all the pissed out compounds (codeine, morphine and morphine-6-glucuronate), it should be a near quantitative yield.
 
^^^ Great! Now who has a piss fetish? J/. BTW I was the one who posted the initial thread (After reading about people drinking pee after eating Fly Agarics).
 
Right, someone is going to have to try this.

Can anyone suggest a good extraction technique to use in this scenario? It doesn't have to be very pure, I think I could stomach a bit of urine. Can anyone also suggest how long I should collect my piss for?
 
Best extraction would be to make the urine alkaline with ammonia soln (not NaOH/KOH because of phenol salt formation), and extract using chloroform or methylene chloride. Best rough and ready way is to evaporate all the water from the piss and extract the dry residue with ethanol or isopropanol. This method will also extract a certain amount of creatinie, urea and other compounds found in urine.

As for collection time, if you take the grapefruit juice 30 mins before the codeine/dihydrocodeine, then collect all urine from 30 mins after taking the codeine/dihydrocodeine for about 6-8 hours, you should recover 90%+ of the original dose as the unchanged compound, morphine/dihydromorphine and the glucuronate conjugate (and at least half should be metabolically O-desmethylated)

Potentially 300mg of codeine could produce anything up to 200mg of morphine/morphine-6-glucuronate.
 
It doesn't work. I just tried it :(

I think it had something to do with my urine being too dilute.
 
Potentially 300mg of codeine could produce anything up to 200mg of morphine/morphine-6-glucuronate
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I hate to break everybody's hearts, but typically 10% of codeine is bioconverted to morphine, and 5-15% are excreted unchanged as codeine, while the rest is metabolized into the BIOLOGICALLY INACTIVE codeine-6-glucuronide and morphine-6-glucuronide.
The grapefruit juice will help reduce the 5-10% of codeine converted to the half-as-active (compared to codeine) norcodine and the 5-10% of the 10% of morphine which are converted to the half-as-active (compared to morphine) normorphine. This will improve the potency overall by between 0% and 2.5%, depending upon how much it inhibits the N-demethylation enzymes.

The idea of recycling the drugs in one's urine IS a sound one, but you can't magically expect the total amount of active material in your urine (and thus the high from it) to ever exceed the amount in your body at the time of urination. In other words: you are ALWAYS going to get LESS high from drinking your pee than you were at the time you created that pee.

Also, the only way to metabolise a majority of injested codeine into MORPHINE (not any of the other weaker/inactive metabolites), is to somehow significantly induce your CYP2D6 enzymes to work faster, while inhibiting your CYP3A4 enzymes.

Unless of course you're this lucky fuck: http://content.nejm.org/cgi/content/short/351/27/2827 [smile]

By the way, I've heard cimetidine and quinidine PREVENT codeine from being metabolised into morphine.

If you read enough patents at http://gb.espacenet.com you'll learn that the epoxy bridge and overall structure of the opiates is much more stable than commonly believed, and that the 3-O-methyl position is typically the first to break in certain conditions. (boiling mineral acids) All opiates with a ketone at the 6 position are even more stable (including hydrocodone and oxycodone), and demethylation is pretty selective to the 3-O position.
 
BTW WhoMe? I was impressed by the number of articles you have amassed at dopers.org. I sent you a PM regarding this. At poppies.org I think there is a patent describing a route to oxycodone that uses codeine as a precursor (yeah, right).
 
Well technically speaking you would not be drinking your piss since you have converted the piss into another chemical means via extraction. You folks are just having a fun word play. It would be similar to you stating that you are eating grass by drinking milk. Not many consider that the grass is the predominate compound that is converted to milk by whatever means the cow processes it by. I really have no knowledge in this area sorry.

Just the chemical reduction and etc means no longer is the original chemical thought to be part of the completed product.
 
Piss is not bad for you, Ghandi drank his own for years. There are many books and websites out there devoted to healing using urine. It can be used to heal a number of internal problems as well as being very potent for healing skin disorders.
 
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