RCs Using stimulants in anti depressant doses without depleting neurotransmitters?

[Harambulus]

Is this a realistic goal or doomed to fail due to inevitable depletion?

I havent really tried them in antidepressants doses in earnest before. Some might say youll always end up doing recreational doses due to fiendish nature of such drugs but Im not really a fiend for them at all and am more interested in a mild high with minimal after effects.

So is it realistic?

Certainly not a regular thing but every few months to give a decent mood lift if in a rut without having to pay for it on the back end given adequate precautions?

My main query is whether such drugs will definately cause total depletion.

I know Ive accidentally breathed in mdma powder in the past once when I was crushing up two grams of crystals. That gave a definite mood lift for a few minutes without any noticeable side effects afterwards.

Also mdppp has caused almost no adverse side effects in the past except the minor residual stimulation.

The stronger the drug tho is the more precarious Im sure.

Straight amphetamine i think causes inevitable toxicity and bad side effects prob due to its long half life.

I took 2-fa recently and that seemed much milder on the system altho I overdid it on the doses there- not intending to take low doses at the time and still suffered depletion so Im unsure if lower doses would yield more positive results.

Im thinking low doses of 2-fa or similar and another mild one like mdai for serotonin.

So could one realistically get a noticeable buzz from them without a comedown if the doses are low enough? and post loading with common supplements afterwards? or does it sound like a futile effort?

 

[NeighborhoodThreat]

Eventually you will have issues with depletion....there's no 100% foolproof antidepressant that's a stimulant.

 

[Harambulus]

How do you mean eventually...ie if you took it daily or if you took it once and it wore off?

If the former this wouldnt be an issue for me since as I mentioned I would only plan on doing them on a sporadic basis with the same sort of frequency most advise taking them recreationally.

 

[Harambulus]

thining about this more I thinkits an 'ill baked' idea actually.

Though taking the usual stims to get high then using the anti depressants on the comedown I think is an idea worth exploring.

Not new obv with tyrosine and 5-htp but things like st johns wort perhaps to add to the mix.

 

[Epsilon Alpha]

If you avoid redosing and take weekends off it would be fairly sustainable depending on on the stimulant in question and your personal neurology. Stims make fairly poor antidepressants due to the quick tolerance to the hedonic effects though if your issues are mainly with energy then it seems possible this could work out. Stimulants may work for depression if one has ADHD or narcolepsy, but for regular depression its a bad idea.

Also I'm going to take this opportunity to shamelessly plug modafinil, aside from Zoloft and Wellbutrin its probably the most "stimulating" antidepressant. Ask your doctor about mirtazapine and modafinil and see what happens, say you're extremely worried about the risk of sexual side effects from an SSRI.

 

[Harambulus]

Interesting.

Yes see Ive considered the prescription route of antidepressants before but I dont like the idea of regular use and they are always saying how you gotta keep taking them for ages.

I dont have as much of an issue with that with something like supplements for instance 5-htp which im giving another try but dont like the idea of tkaing a chemical all the time. Id also been recluctant to take those regualarly but since therapy isnt a realistic option Im thinking its time to give something else a go to tackle the depression and these are a lesser evil/more benign than taking prescription drugs.

My depression comes in bouts which is why Im interested in taking stims to blast my way out altho that idea has failed miserably in the past leaving me worse off.

In hindsight I probably am depressed all the time but it wells up and reaches a peak at certain times which would cause me to take stims.

So my main thing atm is dealing with the underlying depression (ny resolution if you will). As I said I dont like the idea of taking chems daily tho would look at that if all else failed. I havent really focused on getting it sorted as Id just been doing this same old cycle of be depressed, get more depressed, take stims, get even more depressed, swear myself off drugs forever, get depressed again, think stims will give me a release etc.

So Im gonna try the supplement route in earnest for a bit 1st. Tried 5htp thru the day yesterday and today and its def been giving me a moodlift- not as pronounced as citalopram (only had one does but def felt serotonin activity and was horny, yawning etc) did when i tried it but Im thinking it could be decent if I keep it up plus adding in some others like st johns which I recall has given the biggest moodlift when I tried that in the past.

Basically Im thinking take supplements to deal with the depression and maybe take stims now and then for the enjoyment and for energy as you say (rather than as an escape as before) and boosters of the supplements to circumvent comedowns.

 

[Znegative]

I think stims would only be effective if you took them vary rarely in your worst bouts of depression. They really are great for that. But for every day use, I find that they turn on me. However, since I also just love being sped up, I often dose too often or too large, which inevitably leaves me with a horrible crash where the depression is 10x worse, or I start to break from reality.

4-FA seems like it could have some potential for low dose usage, as for me I found it pleasant but not fiendish like coke, MDPV or 4-MCC. In fact it wasn't even that stimulating at all, just made me feel nice and calm, but with a little extra energy. If I had to choose a RC that I thought I could control my usage of, it would probably be this one.

 

[Opieator]

Wont work

 

[Harambulus]

Funny you mention this one as that is exactly what Id been looking into.

Ive tried 2-fa and loved that but am interested if 4-fa will have the 2-fa flavour with a little more depth.

Forget the antidepressant OP topic, sort of written that off. My goal has diverted to getting high without a crash.

Relatee to OP tho Im now interested in a stimulant with some serotinergic activity so I can reflect and work on my acceptance of some insecurities I have. 2-fa is fun and a great- the best Ive ever had- stimulant but didnt give me any insights except I am a horny bastard :D- so nothing new there. 4-fa seems like it might be the ticket from what Im reading. Im not inspecting the super love the world that mdma brings but just some more depth than straight dopa. From what Ive read 4-fa is likened to MDMA lite which sounds like what Im after.

Whats your opinion?

I think stims would only be effective if you took them vary rarely in your worst bouts of depression. They really are great for that. But for every day use, I find that they turn on me. However, since I also just love being sped up, I often dose too often or too large, which inevitably leaves me with a horrible crash where the depression is 10x worse, or I start to break from reality.

4-FA seems like it could have some potential for low dose usage, as for me I found it pleasant but not fiendish like coke, MDPV or 4-MCC. In fact it wasn't even that stimulating at all, just made me feel nice and calm, but with a little extra energy. If I had to choose a RC that I thought I could control my usage of, it would probably be this one.

 

[The.Ghost]

From wikipedia:

Cephalon plans to conduct clinical trials evaluating the use of Nuvigil [armodafinil] as a treatment for serious medical conditions such as bipolar depression and fatigue in conditions such as Parkinson's disease and cancer.

It *may* be an antidepressant. I'm also scripted the stuff and can't remember what for. It does certainly make my brain work better, though.

My depression comes in bouts which is why Im interested in taking stims to blast my way out altho that idea has failed miserably in the past leaving me worse off.

I'm curious, are you constantly mild-moderately depressed with occasional acute bouts of very severe depression?

I ask because I used to be like that. I later found out that the severe downturns were, in fact, mixed manic-depressive episodes (basically, hypomanic episodes mixing with the usual depression) and that I had bipolar disorder all along. If you have those acute bouts, you might want to have yourself checked.

 

[Harambulus]

I guess how you explained it soudns about right, but isnt it just semantics?

Ie depressions is depression? I mean of course theres diff shades not trying to say that but does it hlep much picking them out vs just resolving to beat the whole thing? Maybe it helps in terms of treatment I guess but since Im not gonna take prescription drugs I dunno if that would change my plans much.

Not disagreeing just interested why it is pertinent.