Ketamine salts solubility

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When You're Trying To Draw Cocaine, But Forget One O And Somehow End Up With A New Creation.

CATHINONEICOCAINE
N-methyl-2-carbomethoxy-3-(benzoyl)-8-azabicyclo[3.2.1]octane

Note: The acetyl (R-(C=O)-CH3) functional group plays an important role in Fragrance Chemistry.

TRIACETYL-2-BZP
1-(3,4-diacetylphenyl)-1-(2-piperidinyl)-2-oxopropane

^--Is It Mellifluous? Possibly.

THE_VAMPIRE_LESTAT
1-(3,4,5-triacetylphenyl)-2-aminoethane

 

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THE_WRIGHT_STUFF
N-cyclopropylmethyl-2-acetyl-3-benzoyl-8-azabicyclo[3.2.1]-octane

Learn To Fly!

A_LIL_IFFY but so are the lottery & the stock market
2-phenyl-3-benzoyl-8-azabicyclo[3.2.1]octane

3-ISO-ESTER-COCAINE
N-methyl-2-carbomethoxy-3-carbophenoxy-8-azabicyclo[3.2.1]octane

SAGACIOUS_THO_SATYRICAL_SALAMANDER
1-(2,6-dimethylphenyl)-1-methoxy-N-allyl-2-aminopropane

INDRA
N-allyl-2-carbomethoxy-3-benzoyloxy-8-azabicyclo[3.2.1]octane

 

[MedicinalUser247]

Got another one. 4-(2-Aminoethyl)Methyl-1-Phenylpropan-2-amine. It's a cross between Dopamine and Meth.

 

[Azed]

Haven't seen any mentions of this drug or its combination products. Anyone have information on Samidorphan. Information on this one seems to be very much limited, anyone with experience should share if they are comfortable.


Best wishes and stay safe!
Azed

 

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I took this new drug for 3 weeks. Extreme dysphoria. One of my least favorite drugs. Had to discontinue.

 

[Azed]

I took this new drug for 3 weeks. Extreme dysphoria. One of my least favorite drugs. Had to discontinue.

Thank you for sharing your experience! Sorry to hear that it didn't work out for your needs. Did you try the Samidorphan alone or in a combination product? If so which one (if you are comfortable sharing)?


Best wishes!
Azed

 

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Olanzapine / samidorphan. Don't recall Dosage.

 

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DRESDEN
1-phenyl-1-oxo-2-(1-pyrrolidinyl)decane

 

[someguyontheinternet]

Got another one. 4-(2-Aminoethyl)Methyl-1-Phenylpropan-2-amine. It's a cross between Dopamine and Meth.

You can't just stick the text names of two compounds together like that, it's nonsensical. It doesn't even create a real structure as far as I can tell

 

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ABRA_DE-OTTOR
1-(4-butyl-3,5-dimethoxyphenyl)-2-aminopropane

 

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CHEAP_GEAR
N-tert-butyl-1-phenyl-2-aminopropane

Insuffulated. For when Wellbutrin (bupropion) won't cut the depression.

N-tert-butyl-MDA
N-tert-butyl-1-(3,4-methylenedioxyphenyl)-2-aminopropane

RIDE_THE_LIGHTNING!
N-tert-butyl-1-(4-methoxyphenyl)-2-aminopropane

 

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STORMY
1-phenyl-1-carbomethoxy-2-(1-piperidinyl)-hept-4-ene

 

[AlsoTapered]

1 hosted at ImgBB

Image 1 hosted in ImgBB

ibb.co

The only modification medicinal chemists might not immediately understand is the replacement of a 3-hydroxy for a 3-carboxamide. This actually halves the potency BUT does substantially increase duration of action by removing the major metabolic pathway of 3-gluconation as demostrated:

8-Carboxamidocyclazocine - Wikipedia

en.wikipedia.org

As for the other modifications. The (S)-beta hydroxy N-2-(2-furyl)ethyl moety:

https://www.unodc.org/images/odccp/bulletin/bulletin_1958-01-01_4_page007_img001_large.gif

https://www.unodc.org/images/odccp/bulletin/bulletin_1958-01-01_4_page007_img002_large.gif

The 14-methoxy:

14-Methoxymetopon - Wikipedia

en.wikipedia.org

The 6-methylene:

Nalmefene - Wikipedia

en.wikipedia.org

In essence, QSAR analysis suggests that the potency of the compound will certainly be in the range of thousands of times that of morphine BUT importantly, all of the references suggest a hugely increased TI. While I would be VERY careful in exploring this aspect, it would appear that while much more potent than morphine, the lethal dose due to respiratory collapse will be similar to that of morphine.

Of course the downside is that the affinity would mean that naloxone is of limited use in the case of overdose. That said, it would appear to be of limited utility in cases of overdose with fentanyl and carfentanil. That said, M5050 has been known since the early 1970s and whenever etorphine or carfentanil as used (only for large mammals), protocol dictates that M5050 is also available in case of accidental ingestion:

Diprenorphine - Wikipedia

en.wikipedia.org

My limited knowledge of diprenorphine is that it's restricted use is due to it's side-effects, specifically hallucinations and dysphoria. I've never quite understood the resistance to the use of diprenorphine when fentanyl or carfentanil overdosage is possible beyond the fact that it's quite an expensive drug to manufacture and since all patents have expired, their is no obvious profit-motive for producers.

I do know that KW bentley and his team also developed the N-allyl homologue of diprenorphine which I presume will have a significantly shorter duration of action but it's interesting that even by the 1960s the N-methylcyclopropyl moiety was favoured over the N-allyl moiety.

 

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Opiates are Killers.

COSMIC_CHARLIE
1-(1S)-phenyl-2-(2S)-aminocyclohexane

R.I.P

 

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UBERMENSCH
1-(3,4-methylenedioxyphenyl)-2-aminocyclohexane

 

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HEPTYL_CHRONICITY
1-(3,5-dimethoxy-4-heptylphenyl)-2-aminoethane

 

[AlsoTapered]

Development of 5-Substituted N-Methylmorphinan-6-ones as Potent Opioid Analgesics with Improved Side-Effect Profile

One of the most important functions of the opioid system is the control of pain. Among the three main opioid receptor classes (<i>μ</i>, <i>δ</i>, <i>κ</i>), the <i>μ</i> (MOR) is the main type targeted for pharmacotherapy of pain. Opioid analgesics such as morphine, oxycodone and fentanyl are...

www.hindawi.com

I consider the above to be the index paper of the work by Helmut Schmidhammer who looked into the 14 substitution of phenanthracine opioids. It's interesting to note that he uses several chemically unrelated MOR/DOR ligands and examines the increased activity of such compounds.

14-methoxymetopon demonstrates the classic 'magic methyl' problem that is the bane of medicinal chemists. While alternatives to his synthesis exist, they are based on recent advances in organic chemistry and all are problematic. As it is he was forced to use methyl iodide and sodium hydride to methylate the quaternary hydroxyl moiety.

I did try to find facile alternatives but all of them proved to be lower yielding than his route.

 

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Phenyl-DOPE
1-phenyl-2-methylaminopropane

The Birch Reaction Can Be Modified So That The Amine Source Is EDTA. Works In Under 60 Seconds Or Less.

 

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SASHA_SHULGIN
1-(3,4,5-trimethoxyphenyl)-2-aminocyclohexane

TAYLOR_SWIFT
1-(3,4-methylenedioxy-5-methoxyphenyl)-2-aminocyclohexane