TheFunkeeJunkee
Bluelighter
- Joined
- Jul 11, 2024
- Messages
- 145
G'day folks.
Kindling is a well known and studied phenomenon when relating to GABAergics, but Opioid kindling seems to be seldom discussed in the literature. It's well known to occur and numerous anacdotes on forums such as Bluelight confirm it's existence. It's complexities are however largely unknown.
I finished my degree last year and have a good 4 years of sobriety. I always told myself I'd stay clean to finish my BSc and I did. After getting employment in the field and making good money I figured I'd roll the dice once more and try to limit my use to the weekends. So I ordered a large quantity of Heroin and have been using maybe 250mg every weekend since February.
Even after 4 years of sobriety, even very small quantities of opioid produce a mild but noticeable withdrawal syndrome. Mostly insomnia and night-time RLS but occasionally a runny nose and a very mild "fever-like head" feeling. It's certainly manageable although it's got me wondering exactly why this happens and how long can someone expect to experience this rapid-onset withdrawal after even decades of sobriety. Have you returned to use after decades of sobriety and found the same to happen?
A brief search of the literature discusses this phenomenon in patient settings but very little outside of large case studies.
My major was in chemistry and neuroscience has only ever been a side interest of mine, but from my understanding receptors are more or less degraded via various mechanisms after at most a month depending on the type. This makes immediate sense as tolerance for various classes of drugs has always returned to baseline after at most a fortnight. How is it that even after half a decade, there can be such a rapid development of tolerance and subsequent withdrawal? This rapid development of tolerance (from my understanding) is also seen with monoamine modulators and α2δ inhibitors.
Another brief question: Many folks on this forum and others discuss the use of competitive antagonists and others drugs in the hope it reduces tolerance. This seems to be supported scientifically. Does anyone have experience using an antagonist after a short binge to reduce tolerance? Was the withdrawal syndrome intensified? I can get a hold of large quantities of Nalaxone and Naltrexone so maybe some recommendations are in order.
Kindling is a well known and studied phenomenon when relating to GABAergics, but Opioid kindling seems to be seldom discussed in the literature. It's well known to occur and numerous anacdotes on forums such as Bluelight confirm it's existence. It's complexities are however largely unknown.
I finished my degree last year and have a good 4 years of sobriety. I always told myself I'd stay clean to finish my BSc and I did. After getting employment in the field and making good money I figured I'd roll the dice once more and try to limit my use to the weekends. So I ordered a large quantity of Heroin and have been using maybe 250mg every weekend since February.
Even after 4 years of sobriety, even very small quantities of opioid produce a mild but noticeable withdrawal syndrome. Mostly insomnia and night-time RLS but occasionally a runny nose and a very mild "fever-like head" feeling. It's certainly manageable although it's got me wondering exactly why this happens and how long can someone expect to experience this rapid-onset withdrawal after even decades of sobriety. Have you returned to use after decades of sobriety and found the same to happen?
A brief search of the literature discusses this phenomenon in patient settings but very little outside of large case studies.
My major was in chemistry and neuroscience has only ever been a side interest of mine, but from my understanding receptors are more or less degraded via various mechanisms after at most a month depending on the type. This makes immediate sense as tolerance for various classes of drugs has always returned to baseline after at most a fortnight. How is it that even after half a decade, there can be such a rapid development of tolerance and subsequent withdrawal? This rapid development of tolerance (from my understanding) is also seen with monoamine modulators and α2δ inhibitors.
Another brief question: Many folks on this forum and others discuss the use of competitive antagonists and others drugs in the hope it reduces tolerance. This seems to be supported scientifically. Does anyone have experience using an antagonist after a short binge to reduce tolerance? Was the withdrawal syndrome intensified? I can get a hold of large quantities of Nalaxone and Naltrexone so maybe some recommendations are in order.
