Benzos Uncoupling of the GABA-A receptor

[fairnymph]

Not many people can claim to be 'casual' pain users although I remain convinced that their is a minority addicted to pain - or, rather, the endogenous opioids pain releases.

For sure.

 

[HealingEnergy14]

In the UK at least, baclofen (which is after all a GABA analogue) is sometimes used to treat such symptoms.

It's certainly not abusable but it does produce a certain amount of sedation. Have you come across it?

It apppears to increase the effect of opioids. It may be an alternative to diazepam. I'm pretty sure it's cheaper.

Baclofen might not be the greatest high but it can certainly be abused, I'm not sure why you would think otherwise. The effects are most comparable to GHB, Phenibut and drugs like that. Although less euphoric and pleasurable.

 

[4DQSAR]

Baclofen might not be the greatest high but it can certainly be abused, I'm not sure why you would think otherwise. The effects are most comparable to GHB, Phenibut and drugs like that. Although less euphoric and pleasurable.

Baclofen gets toxic pretty quickly. In that way it is to some extent self-limiting. Even slightly above prescribed doses many people develop side-effects such as nausea and confusion along with the typical effects of the related compounds.

I actually wonder if the -Cl was chosen because in animal models, it showed the lowest rate of self-administration of the series.

I'm not saying it cannot be abused - but then some people will take ANYTHING that is psychoactive. A few years ago a friend of a friend vouchsafed that the quetiapine they were prescribed for bipolar disorder found ready buyers. I mean the 200mg tablets. Fine it being unconscious for 24 hours is your idea of fun, I guess. Oddly, just a year later their psychiatrist decided that 200mg was inappropriate and they were prescribed 25mg tablets. THAT is how shady the pharmacutical industry is and why in the UK we don't use the DSM V - we stick to the DSM IIIa. It became clear that manufacturers were inventing disorders for which they just happened to have a medicine that was IDEAL. Indication creep is creepy.

 

[Conky]

ah, yes. I almost forgot people inject suboxone

 

[bigjackaal96]

Baclofen gets toxic pretty quickly. In that way it is to some extent self-limiting. Even slightly above prescribed doses many people develop side-effects such as nausea and confusion along with the typical effects of the related compounds.

I actually wonder if the -Cl was chosen because in animal models, it showed the lowest rate of self-administration of the series.

I'm not saying it cannot be abused - but then some people will take ANYTHING that is psychoactive. A few years ago a friend of a friend vouchsafed that the quetiapine they were prescribed for bipolar disorder found ready buyers. I mean the 200mg tablets. Fine it being unconscious for 24 hours is your idea of fun, I guess. Oddly, just a year later their psychiatrist decided that 200mg was inappropriate and they were prescribed 25mg tablets. THAT is how shady the pharmacutical industry is and why in the UK we don't use the DSM V - we stick to the DSM IIIa. It became clear that manufacturers were inventing disorders for which they just happened to have a medicine that was IDEAL. Indication creep is creepy.

Just like how they claim SRI/SNRI's don't affect 5HT2 receptor in the same manner as Shrooms. Yet DXM shows otherwise It too warm to be from NMDA blockade triggering D2 agonism & has no direct 5HT2A agonism. Even DMT Is a SRI/SRA(115nM) but has direct 5HT2A agonism.

I'm sure I saw that a Pharmacy had to hide the SNRI's because a few who tried them at sudden high doses got effects matching Shrooms but much more stimulating.