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  • N&PD Moderators: Skorpio | someguyontheinternet

tryptamine enzymes crossing psilocybe and 5-Meo-DMT

IntoXicated

IntoXicated

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Mar 1, 2004
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Nebraska
I will quote Dr. Shulgin Link
However there is a very interesting study that took place in Leipzig about 15 years ago. Jochen Gartz, a mushroom explorer whom I know quite well, has done some fascinating studies with Psilocybe species by raising them on solid media containing strange tryptamines that are alien to the mushroom. Apparently the enzymes that are responsible for the 4-hydroxy group of psilocin are indifferent to what it is they choose to 4-hydroxylate. He has taken things like DPT or DIPT and put them in the growth media and the fruiting bodies that came out contain 4-hydroxy-DPT or 4-hydroxy-DIPT instead of psilocin. In fact, he has a patent on the process. These active compounds are made by the mushroom so they really are natural and yet they never have been observed in nature. I'll give you even odds that if you put spores of a psilocybe species on cow droppings loaded with 5-MeO-DMT you would come out with mushrooms containing 4,5-HO-MeO-DMT. This way you avoid a 10 step synthesis by growing a psychoactive mushroom that contains no illegal drug.
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I find this interesting. Can DMT be used instead of 5-MeO-DMT?
 
yeah, and you'd end up with 4-HO-DMT; AKA PSILOCIN. There might be some threads on this in here allready, do a search. (though maybe it's cacti.. try fungi as a search string).

I think there's evidence that you end up with more psilocin/psilocybin... I'm not an expert on that one... wait for the other guys (I might flick it to PD if we don't get some proper answers in a while)
 
Yes you can get hugely increased yields of psilocin/psilocybin; I think it must be downstream of the rate limiting step in the biosynthesis. If you feed the fungus DET you get 4-HO-DET, same applies for DPT, DiPT, MiPT, MET etc etc etc.

L-DOPA works in a similar way if you inject it into mescaline producing cacti a few weeks before harvesting.
 
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