well I know you can have a sezuire on mushrooms, if they are contaminated. So unlikely but that would be my main concern. increased energy, feelings of well-being, heightened perceptions, dissolution of stress, freedom, or possibly a loss of appetite, coldness in the extremities, increase of heart rate, numbness of the mouth and adjacent features, nausea, elevated blood pressure, weakness in the limbs (making locomotion difficult), muscle relaxation, yawning, swollen features and pupil dilation.
Now there are pros in there that could help the taper, but there are cons too.
Nausea and weakness would be my concerns. If you are on a taper, mushrooms might just magnify these and make you feel like total hell.
Really it is just a choice you are going to have to make based on the info you have...