Harm Reduction Tramadol + stimulants

[Tranced]

My friend is going to London today and will be no doubt taking a variation of drugs, including Cocaine, MDMA and Ketamine. He doesn't have any Benzos and so was talking about taking Tramadol as a general cure for sketchiness/comedowns/sleep etc

I've told him that from what I've read before, Tramadol is not at all in the same league as benzos in terms of safety when mixing with other drugs.

Is this correct? What should be avoided and why? Going to tell him to steer clear anyway, don't fancy him experiencing a seizure tonight, for starters.

Thanks a lot.

 

[Xynthetic]

If he's going to use Tramadol I'd suggest using it by itself. It has a rather complex mechanism of action affecting levels of serotonin and dopamine on top of its agony of the mu opioid receptor.

Here's a blurb from wikipedia: Tramadol acts as a μ-opioid receptor agonist,[48][49] serotonin releasing agent,[6][7][8][9] norepinephrine reuptake inhibitor,[49] NMDA receptor antagonist,[50] 5-HT2C receptor antagonist,[51] (α7)5 nicotinic acetylcholine receptor antagonist,[52] and M1 and M3 muscarinic acetylcholine receptor antagonist.[53][54]

The mechanism of action of benzodiazepines is much simpler as they only affect the GABA receptors.

 

[Rx_]

advice

If he's going to use Tramadol I'd suggest using it by itself. It has a rather complex mechanism of action affecting levels of serotonin and dopamine on top of its agony of the mu opioid receptor.

Here's a blurb from wikipedia: Tramadol acts as a μ-opioid receptor agonist,[48][49] serotonin releasing agent,[6][7][8][9] norepinephrine reuptake inhibitor,[49] NMDA receptor antagonist,[50] 5-HT2C receptor antagonist,[51] (α7)5 nicotinic acetylcholine receptor antagonist,[52] and M1 and M3 muscarinic acetylcholine receptor antagonist.[53][54]

The mechanism of action of benzodiazepines is much simpler as they only affect the GABA receptors.

Good Advice..!! I would not mix Tramadol after all the above drugs listed. If he has no benzos to come down with i would recommend 50-75mg Benadryl (Diphenhydramine) ..to bad he can't get a benzo ..maybe he will get lucky and find someone who has some. I never do any stimulants without a benzo to come down with anymore. If he can eat something that will help to come down some.

 

[Sprout]

DPH and codeine should help if he has no access to benzos, they did for me.

 

[mdmantpa]

good advice so far, Ultram wont even work for the come down as it is not a true opiate and does not possess CNS depressant properties, from my experience its actually more of an upper. It also increases heart rate as well as lowers the seizure threshold, which will already be lowered from the stimulant usage....overall its a sketchy idea and I would not suggest finding out the hard way. Like someone else suggested try benadryl or tylenol pm for the comedown if you have nothing else, hell even alcohol or marijuana would be better choices in this scenario