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tramadol - seizure threshold - benzodiazepines

lurching

lurching

Bluelighter
Joined
Aug 1, 2009
Messages
1,973
far as i know, this has been covered in 2007 once on this board but i'd like some second opinions if possible.

i have been taking tramadol "extend release" (Sandoz Retard 150) at doses around 300 - 400mg per 24 hours. that is: 300mg extended release in the morning, sometimes with a "boost" of 100mg instant release 6-8 hours later.
or, 150mg extended release in the morning, with another 150mg extended release + 100mg instant release 6-8 hours later.

i have not been experiencing any seizure symptoms, although the serotonogenic properties of tramadol appear to have slight side effects in the form of a light pressure on the eardrums and jaw-muscle tightening. or am i? how would one notice?

first and firstmost: are these dosages safe? i use twice a week normally, but have gone up to four times a week - for almost two months now. safe not only in the sense of neuro-toxicity, but physical dependence?

secondly: would benzodiazepines reduce risk in therapeutic doses? i am thinking of combining a long-lasting benzo like clonazepam with the tramadol extended release. what dose would be advisable? 1mg xanax is "moderate" for me.

just curious
 
The doses that you're taking are right on the line of no risk / risk with regards to seizures (400mg).
Neurotoxicity is not an issue with Tramadol as far as I'm aware otherwise the FDA wouldn't have allowed it to go on the market. Physical dependence is most likely already an issue but it'll be far from a concern to be honest, atleast Opiate withdrawal wise. Most people find the SSRI discontinuation side effects to be more unpleasant than the Opiate withdrawals.

Yes, a Benzo would reduce the risk of experiencing a seizure but nobody can say exactly by how much. It's a very personal thing and depends on many factors. But it's also good to remember that respiratory depression becomes more of an issue upon ingesting multiple CNS depressants.
But that should be too much of a dangerous issue with such a weak Opioid as long as the dose of Benzo isn't too big also.
I wouldn't be able to comment on the dose you should take of Clonazepam of Alprazolam with regards to their Anti-Epileptic abilities so maybe someone else could shed some light on that.
 
monstanoodle said:
The doses that you're taking are right on the line of no risk / risk with regards to seizures (400mg).
Click to expand...

are they? note that i'm using extended release tramadol, which (as i've understood) releases half of its dose immediately and gradually spreads the rest of its dose over the next eight hours.

can that be compared to "immediate release" regular tramadol?

Neurotoxicity is not an issue with Tramadol as far as I'm aware otherwise the FDA wouldn't have allowed it to go on the market. Physical dependence is most likely already an issue but it'll be far from a concern to be honest, atleast Opiate withdrawal wise. Most people find the SSRI discontinuation side effects to be more unpleasant than the Opiate withdrawals.

Yes, a Benzo would reduce the risk of experiencing a seizure but nobody can say exactly by how much. It's a very personal thing and depends on many factors. But it's also good to remember that respiratory depression becomes more of an issue upon ingesting multiple CNS depressants.
But that should be too much of a dangerous issue with such a weak Opioid as long as the dose of Benzo isn't too big also.
I wouldn't be able to comment on the dose you should take of Clonazepam of Alprazolam with regards to their Anti-Epileptic abilities so maybe someone else could shed some light on that.
Click to expand...

ok, cool, although alprazolam would be too sedating (and short-lasting) for my purposes i guess.
 
lurching said:
are they? note that i'm using extended release tramadol, which (as i've understood) releases half of its dose immediately and gradually spreads the rest of its dose over the next eight hours.

can that be compared to "immediate release" regular tramadol?
Click to expand...

Well you're going to end up with it all in your system eventually.

And yes it would be better to use a longer-acting Benzo for the job, so Clonazepam would be a better choice.
 
i had a seizure on 200mgs once
i recently took 175mgs the other day along with 3-4 mg of klonopin, i can't remember how much and i was fine....just dont drink alcohol...that seemed to be the trigger for my seizure...i only had maybe half of a shot before i felt too fucked up with 200, went to take a piss and ended up seizing out and pissing my pants.
 
The complication with higher doses of tramadol is that the natural seizure threshold can vary among people, and an individuals seizure threshold can vary from day to day depending on a variety of factors, from stress and lack of sleep to other medications.

Taking a benzodiazepine would decrease the risk of seizure. It would need to be a longer acting benzodiazepine, so clonazepam would be ideal as others have mentioned. Just be sure not to overdo the benzo+tramadol combo in terms of respiratory depression.
 
be careful with tramadol too, once you have been on it for about a week or so you really notice the anxiolytic SSRI and SSNRI effects and those combined with its opiate effects and the benzo buzz of klonopin make it really enjoyable and an excellent anti-depressant. definitely dont underestimate the power of tramadol.... i advise not taking more than 100mg per 12 hours
 
crazykidck69 said:
tramadol is fkn junk! Get some Hydros!
Click to expand...

There is always a guy like this in a tramadol thread.. Its fine if you don't like tramadol, but saying shit like that isn't helping anyone.

Anyways, I find tramadol to be a fine substance. I don't use it to get fucked up as I would with standard opiates, but it still has it's place. I enjoy using it in social settings, when studying, or just to lift my mood.

I read in another tramadol thread that seizures induced by tramadol are typically preceeded by muscle smasms. Does anyone know if there is any truth to this? I ask because this is a common symptom of mine when taking tramadol. Not exactly muscle spasms, but a jittery feeling and slight muscle twitches. Such as my hand shaking slightly. If you have taken IR doses of 400mg then perhaps you know what I am talking about.

I find benzos (I use clonazepam for it's longer lasting effects) does a great job of reducing the jittery feeling - which may tie into the fact that benzos reduce the seizure risk.
 
I've taken literally about 2000mg of Tramadol (Ultram) over an 8 - 12 hour period with no ill effects aside from headaches and the feeling of a 'heavy head'. I'm not saying it is great for your body but I've never had a seizure or anything like that.

I generally start out popping 5 - 8 at a time to begin the day then taking 2 - 4 at a time throughout the day. I've probably taking at the most 30 100mg pills over an 18 hour period. Then repeat the process the next day.

Then I reduce my dosage slowly over the next couple of days and quit totally for about two days then begin the cycle over again.

I've done with for about a year.

Now with Percocet 10s, the most I generally take at a time are 3, taking no more than about 10 a day.

Lortabs 10s I usually start with 2 - 4 at a time and take up to12 - 15 a day.

I don't interact these drugs however.

Sometimes I will mix with Xanax or Klonopins as well but rarely.
 
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