I've read all or almost all opiate/tramadol potentiation threads and this seems to be the only reference to this potentiator. I can't find any additional info on this on BL. I read the below statement posted in one of the many opiate potentiation threads- which was regurgitated from a magazine article written in July 2000 which can be found here: http://opioids.com/opiates/index.html
Interesting site.
My QUESTION is:
Does Meclizine also potentiate Tramadol?
Tramadol is unique enough that I can't safely assume that what is effective on "opiates" in general is effective on an atypical opioid such as Tramadol.
15. Meclizine (Dramamine II) - This is effective at reducing the nausea of opiates in a lot of people and at therapeutic doses will cause some across-the-board increase in the effects of opiates (about 35% that of diphenhydramine) and has been demonstrated to steepen or move out the dose-to-response curve of opiates, hydrocodone particularly. The antihistamines cyclizine (Marezine) and tripelennamine (PBZ, Pelamine) also have similar effects. The latter is a strong anticholinergic and was famous for being mixed with pentazocine (Talwin) back in the old days before they started mixing it with Narcan. All of these can be taken in the therapeutic doses along with the normal dose of the opiate.
Interesting site.
My QUESTION is:
Does Meclizine also potentiate Tramadol?
Tramadol is unique enough that I can't safely assume that what is effective on "opiates" in general is effective on an atypical opioid such as Tramadol.
15. Meclizine (Dramamine II) - This is effective at reducing the nausea of opiates in a lot of people and at therapeutic doses will cause some across-the-board increase in the effects of opiates (about 35% that of diphenhydramine) and has been demonstrated to steepen or move out the dose-to-response curve of opiates, hydrocodone particularly. The antihistamines cyclizine (Marezine) and tripelennamine (PBZ, Pelamine) also have similar effects. The latter is a strong anticholinergic and was famous for being mixed with pentazocine (Talwin) back in the old days before they started mixing it with Narcan. All of these can be taken in the therapeutic doses along with the normal dose of the opiate.
