Tolerence is a bitch

[streetsurfer]

Man, The other day I started prozac, my god, all of a sudden (after 3 days) I wasn't shy, I was charming the pants off everyone I came across. I felt so positive about the direction my life was heading and felt centred in myself.

One glorious Day

Then, I return back to the old me. Timid, angry, repetative intrusive thoughts sad sad sad. All these things are still good that have happened, but they don't make me feel good.
I am so borderline, my moods cycle from suicidality to elation several times a day. I am on lamictal 250mg but it doesn't seem to be working. I am just so sick of it.
Amygdala Dysfuntion yes? How do I deactivate it, could you, through psychosurgury do so? what about D- cyclozine, Anyone know much about that? Does the Amygdala serve any fucking purpose asides cause misery? Lastly, to get back on topic, do you think this study would be applicable to other drugs like ssri's so they work longer than a god damn week.

Many Thanks

Chronic elevation of brain-derived neurotrophic factor by ampakines.


J Pharmacol Exp Ther. 2003 Oct;307(1):297-305. Epub 2003 Jul 31.
"The ampakine CX614 positively modulates alpha-amino-3-hydroxy-5methyl-4-isoxazolepropionic acid (AMPA) receptor-gated currents and increases brain-derived neurotrophic factor (BDNF) expression. In rat hippocampal slice cultures, CX614 rapidly increases BDNF gene expression but with time, mRNA levels fall despite the continued presence of active drug. The present study examined this apparent refractory period and the possibility that spaced ampakine treatments could sustain elevated BDNF protein levels. In cultured hippocampal slices, CX614, a second ampakine CX546, and the cholinergic agonist carbachol each increased BDNF mRNA levels with acute (3-h) treatment. After 4-day pretreatment with CX614, fresh ampakine (CX614 or CX546) did not induce BDNF mRNA, whereas carbachol did. Western blots confirmed that after an extended period of ampakine treatment, AMPA receptor protein levels are indeed reduced, suggesting that with longer treatments receptor down-regulation mediates ampakine insensitivity. Finally, using a "24-h on/24-h off" CX614 treatment protocol, the ampakine refractory state was circumvented, BDNF mRNA was induced with each ampakine application, and elevated BDNF protein levels were maintained through 5 days in vitro. These results suggest that spaced ampakine treatments can be used to sustain elevated neurotrophin levels and to test the utility of this manipulation for neuroprotection by endogenous neurotrophins." [Abstract]

 

[hugo24]

Maybe,your problem is that you switch,mix and change too many drugs too many times in a too short time?Everytime adding a further impetus to the cycle of imbalance.

A case for comparison:my father took at some point 4 different drugs against high blood pressure,and not the lightest ones,I wondered how he even could stand on all the stuff.The fourth he added was I think Diovan,with no effect at all.Then,the doctor decided to quit them all-and what happened?The blood pressure started to lower!

Its not the first story I hear of people quitting a shitload of cascading (prescribed) drugs (and the USA is a fucking overprescriber of all kind of shit!) and a bad condition slowly got into a good condition.Let the natural corrective forces of your body work on it to find a balance.But you need to be mentally prepared and work on it.

 

[jasoncrest]

Tolerance develops quickly, even to non-recreational helpful drugs like Prozac....

For me the only way to fight depression, bad mood, lack of self-confidence, etc... is to switch every 4 months from one kind of drug to another...

Because you will develop a tolerance to every kind of mood-brighteners, Prozac, other antidepressants and everything else that makes you feel good. So you have to switch between them...