Tolerance of Adderall with Famodine

[tacybear714]

I posted a similar topic on BDD and never got an answer so I experimented for myself to see what the effects of taking Famodine with my adderall (that I take as prescribed) would be as far as potenation. Feel free to hop on over there to see what happened. (Ty what you would expect).
This has however got me concerned because I feel 'stronger' effects that I will build a tolerance quicker. I do take chelated magnesium for tolerance reduction (most of the time - it kills my stomach - even if I take it at night it sometimes wakes me up with a stomach ache) anyways…the amphedmine ramble aside tell me about the effects of antacids (specifically Pepcid) on adderall/amphedmines.

 

[pasha]

Homeless -> Basic Drug Discussion

 

[BlueStar13]

Taking antacids will increase the absorption of certain drugs including amphetamines and, from what I've heard, opiates too. Basically what happens is more of the drug is able to be absorbed and retained in the body, leading to an increase in the AUC(Area under the curve - this is an indicator of how much of a drug you have absorbed and how long it stays in your system, an increase in this value usually means an increase in your maximum high and/or duration). Now, don't expect antacids to be some kind of miracle potentiator but do be wary of increased effects, so maybe take a little less amphetamine the first time you try this. I've heard that the best time to take antacids before the medication that you are trying to potentiate is about half an hour before you take the pill. Additionally, if you want more of your Adderall to be absorbed, don't drink any soda or other acid beverages during this period, as they will increase the acidity of your stomach thus negating some of the pH-lowering properties of the antacids.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670101/
Check out this link and ctrl-f antacids if you want a citation.

 

[tacybear714]

Thank you so much. I understood about TUMS and such, but was hazy about other antacids. I am actually most concerned with the drugs becoming overwhelming (as I am truly using them as scripted for ADD) at work, or the dreaded tolerance building too quickly. The lack of food from eating less from the Adderrall, has made my heartburn awful. The crazy thing is for once in my life all of this is legit, so I am trying to be responsible. Thank you again for your informative, clear, and through reply!

 

[BlueStar13]

No problem. Oh, and if you want another drug that can prevent tolerance formation, in addition to your chelated magnesium, you should check out Dextromethorphan - the main ingredient in msot OTC cough syrups. Studies, and multiple anectodal reports, have stated that it can slow the development of tolerance to both opioids and amphetamine type compounds. If you do decide to use it, be sure to get either a gel capsule or syrup that contains only DXM as the active ingredient, and dose no more than 30 mg per day, as at higher dosages it, in combination with amphetamine, can cause some strain on the heart. However, the benefits of a lower tolerance probably outweigh the minor cardiac risks taken when combining the two.

Here's the study(it was done on morphine, but the same concept should apply to amphetamine):
http://www.ncbi.nlm.nih.gov/pubmed/8951930http://www.ncbi.nlm.nih.gov/pubmed/8951930

 

[tacybear714]

Most nights I take the chelated magnesium and 1 -1.5 mg of ativan (lorazpam) - to help with sleep. Wpuld the DXM interact negatively with either of those? I bought some, but am just leery of mixing too many substances. I have a 2 year old that I have to be around for

 

[bronson]

Adderall and DXM combined can cause a rise in serotonin levels in some individuals. It varies on a person by person basis, but if it is something you are still considering, start with a low dose of DXM, as if you're having to take other things to help with sleep it's likely the Adderall is still active in your system.

The main thing you want to avoid is serotonin syndrome which is no fun at all. Symptoms include:

• Cognitive effects: headache, agitation, hypomania, mental confusion, hallucinations, coma
• Autonomic effects: shivering, sweating, hyperthermia, hypertension, tachycardia, nausea, diarrhea
• Somatic effects: myoclonus (muscle twitching), hyperreflexia (manifested by clonus), tremor

(Source)

The more severe symptoms indicate highly increased levels of serotonin, whereas the lesser ones are a sign you're starting to tread in very dangerous territory. A low dose of DMX should be fine, but start as low as possible, and titrate up very slowly for your own sake.

 

[Intenselife]

I feel your pain with the dumb adderall tolerance thing. After taking it as prescribed for the first 5 days (20mg ir twice a day) i realized the euphoria, extreme motivation/concentration, mood lift started decreasing, and i'd be left feeling a little depressed when the meds would wear off with a pretty big headache. I now take breaks in between dosing because luckily my adhd symptoms are mild and i can function most days without the medication.

This keeps my tolerance pretty low, and gives me the maximum benefits of the medication when i take it without as much side effects. But although i have yet to get the chelated magnesium, you might want to look into getting L-tyrosine as well because it is one of the few vitamins that has a significant effect on dopamine levels (which adderall mainly affects). If you take it once a day or twice a day, or in my case a few times a week, it helps re-store the dopamine the adderall burns out thus preventing tolerance to keep the medication working.

I sometimes combine the L-tyrosine with the adderall and notice even a further boost in the adderall working since i'm not frying out my dopamine receptors and it helps replenish and your brain but, it is recommended sometimes not to the mix the two so if you did get it, i would recommend just taking a small dose at night when your medication has woren off.