Stimulants To Potentiate Effects and Reduce Tolerance

[themerv]

mainly using my Dexedrine script to get a lot of grad school work done and a lot of studying. Thus, im looking to make the most of my amphetamine. hopefully there are some knowledgeable people here who can help me =)

I've read that glass of water with (1/4 or 1/2 teaspoon? -correct me if i'm mistaken) Baking Soda (Sodium Bicarbonate) 30-45min before I take my Dexedrine will provide a much more alkaline pH level in my stomach thereby increasing the absorption of the amphetamine. Have heard it works very well by many sources.

A few additional questions regarding this, How does Tums Regular/Maximum Strength (Calcium Bicarbonate) compare to Baking Soda (Sodium Bicarbonate). Both are bicarbonates that will elevate stomach pH. Which one is more effective in terms of increasing amphetamine absorption?
It seems both are bicarbonates, so i would assume the're equal?

Next, how does Alka-Seltzer Gold (non-aspirin) compare to Baking Soda and Tums?
Here are the ingredients:
Anhydrous citric acid 1000 mg.
Potassium bicarbonate 344 mg.
Sodium bicarbonate (heat-treated) 1050 mg.

is it better than Tums, Baking Soda? neither?

Lastly, I've read magnesium supplement can somewhat help reduce tolerance, therefore i'm interested in it. Of course there are many variations, but i've read chelated versions are best? I've heard the magnesium glycinate is pretty okay too. Any suggestions on dosages? 800-1200mg are what i've read, need confirmation. And the timing of these dosages, should i take the magnesium supplement before or after taking Dexedrine, or simultaneously? or right before bedtime?

Many thanks to all who help!
your input is greatly appreciated.


P.S. why is Pepcid AC not used to create alkaline pH in stomach?

-the Merv (long time reader, first time poster)

 

[DoctorNinja]

Ok if you want to study forget all about antacids, it simply doesn't work. You'll get a huge euphoria for 30min and crash 2 hours later, it ruins the study. Unless you take pills every 2 hours you'll crash and won't study that well after.

What you want for study is to take the amphetamines on normal stomach and increase dose until you find something that works best for you. So study potentiation:

- Memantine (best study potentiator we have atm. good for memory good for everything)

- Caffeine with opiates like codeine for the crash. When you study for 10 hours and the amphetamines begin to crash you probably get headache, lose focus. To prevent pain and crash, you take opioid with caffeine. Caffeine potentiates amphetamines and eases the crash, opiate kills pain, all 3 together, you can work for 4 more hours.

I wouldn't worry about antacids, if you want to do serious stuff you won't need them. I take antacids when I wana binge...when I study I take acids.

So the dose could be:

20mg dexamphetamine now

25mg dexamphetamine 3 hours later

This is the same as 55mg dexamphetamine XR which lasts 6-7 hours.

 

[themerv]

In terms of caffeine source, what do you recommend? I'm assuming no energy drinks since its acidic. So best bet is to just stick with standard coffee?

sometimes to ease the crash, i take 2-3g piracetam with choline source + water.

additionally, any advice on magnesium source? and dosage + timing of the dosage?
would love to prevent some sort of increase tolerance as i need my medication to be effective for as long as possible -- usually pretty serious about getting work done.

thanks for the help

 

[DoctorNinja]

If you want 24 hours of study in a row you can do:

time 0: 5mg dex

time 3: 7.5mg dex

time 6: 10mg dex

time 9: 12.5mg dex

time 12: 15mg dex (painkiller!)

time 15: 17.5mg dex (painkiller! redose #1)

time 18: 20mg dex (painkiller! redose #2)

time 21: 22.5mg dex (painkiller! redose #3)

It's too long to explain why you have to keep increasing the dex dose throughout the day. Done it once, works well. After 24h I felt filled with energy and able to achieve things. Do that too many times and you won't stay around for long to tell about it haha still, for emergency study it's great.

 

[themerv]

haha, just looking for 10-12 hours of solid production on a daily base while being semi-healthy and keeping the meds effective, but i'll keep that 24hr in mind.

 

[DoctorNinja]

In terms of caffeine source, what do you recommend? I'm assuming no energy drinks since its acidic. So best bet is to just stick with standard coffee?

sometimes to ease the crash, i take 2-3g piracetam with choline source + water.

additionally, any advice on magnesium source? and dosage + timing of the dosage?
would love to prevent some sort of increase tolerance as i need my medication to be effective for as long as possible -- usually pretty serious about getting work done.

thanks for the help

I'm in Canada so I have these bottles of 222s, 15mg caffeine 8mg codeine per pill so the extract kind of provides both in my case. I've done the extraction...more than 500 times so It takes me 2-3 minutes maximum to do it in a public library...by looking at me you wouldn't suspect a thing, I'm just pro at it lol.

 

[DoctorNinja]

haha, just looking for 10-12 hours of solid production on a daily base while being semi-healthy and keeping the meds effective, but i'll keep that 24hr in mind.

XR pill would cover 7 hours followed by IR booster, or simply 3x IR taken like this:

time 0: 10mg IR

time 4: 12.5mg IR

time 8: 15mg IR

Covers 12 h


time 0: 10mg IR

time 3: 10mg IR

time 6: 10mg IR

Covers 9-10h

The amount I put is for example, you may require less or more.

 

[themerv]

i use XR, i dont need to split anything like you did. usually last 6-8hrs clean. then coffee i think is good to get me to 10. much simpler haha.

anyways, can someone else chime in on the tums vs baking soda prior to dexedrine?
even the magnesium.

 

[Captain.Heroin]

Most amphetamine potentiation relies in you taking a break from amphetamine. Nothing else works very well.

Magnesium is very important for your diet overall. I would start taking this as a supplement before you take any amphetamines, probably 1/2 to 1 hour before you take amphetamine.

NMDA antagonist drugs like ketamine (another example listed above would be memantine) are very useful but typically work best by themselves during a period of abstinence from amphetamine.

There are also negative experiences that can be had from the use of NMDA antagonist drugs. Some people may not like psychoactive effects of ketamine. Other people may like the psychoactive effects of ketamine too much, consequentially begin abusing ketamine, and end up with ketamine bladder syndrome (KBS).

For these reasons, I would just suggest with going on a break.

 

[themerv]

Most amphetamine potentiation relies in you taking a break from amphetamine. Nothing else works very well.

Magnesium is very important for your diet overall. I would start taking this as a supplement before you take any amphetamines, probably 1/2 to 1 hour before you take amphetamine.

NMDA antagonist drugs like ketamine (another example listed above would be memantine) are very useful but typically work best by themselves during a period of abstinence from amphetamine.

There are also negative experiences that can be had from the use of NMDA antagonist drugs. Some people may not like psychoactive effects of ketamine. Other people may like the psychoactive effects of ketamine too much, consequentially begin abusing ketamine, and end up with ketamine bladder syndrome (KBS).

For these reasons, I would just suggest with going on a break.

that was really informative and actually to the point. so thanks!

what is your take on increasing stomach pH to increase amphetamine absorption -- say with Tums or baking soda?

that way i'll be able to take less mg's, while getting a stronger effect? or should i just avoid it?

 

[Captain.Heroin]

that was really informative and actually to the point. so thanks!

what is your take on increasing stomach pH to increase amphetamine absorption -- say with Tums or baking soda?

that way i'll be able to take less mg's, while getting a stronger effect? or should i just avoid it?

I would just take one Tums before taking amphetamine. I would choose tums or magnesium, and avoid using both.

You don't need to increase your stomach pH by very much. This isn't going to cause much of a potentiation. With drugs like benzodiazepines or opiates, there are more choices for synergy. I would just avoid drinking acidic drinks or consuming acidic food. Meaning, drink water, not soda.

 

[NeighborhoodThreat]

I want to echo what Captain.Heroin said about magnesium supplements. It is extremely important to take 500-750mg daily when using amphetamines, and even when you're not taking amphetamines. It will help your anxiety (if you get anxiety with amphetamines at all), any muscle aches, and tolerance.

 

[Captain.Heroin]

I want to echo what Captain.Heroin said about magnesium supplements. It is extremely important to take 500-750mg daily when using amphetamines, and even when you're not taking amphetamines. It will help your anxiety (if you get anxiety with amphetamines at all), any muscle aches, and tolerance.

I also found this information relative enough to share with everyone...

Magnesium is a vital component of a healthy human diet. Human magnesium deficiency (including conditions that show few overt symptoms) is relatively common, with only 32% of the United States meeting the RDA-DRI; low levels of magnesium in the body has been associated with the development of a number of human illnesses such as asthma, diabetes, and osteoporosis.

http://en.wikipedia.org/wiki/Magnesium#Biological_role

Magnesium in treatment-resistant depression.

 

[InvisibleEye]

Thanks to you guys, I wasn't aware of the benefits of taking magnesium, let me rush to the pharmacy now...

 

[DoctorNinja]

750 may be overdone but do at least 250 magnesium. Since you don't get high and don't take large amounts (in which case 500-750 may be required).

Remember, you want to potentiate towards the end of the trip. If you potentiate in the beginning, you get a high, euphoria and then a huge crash. If you want to study you dont want that. You want no potentiation for first 3-4 hours and then potentiation when the effects start to ware off so that you increase the duration of your medicine.

I can study for 10 hours straight with only ONE instant release amphetamine dose:

time 0: 15mg

time 3: famotidine HCl 20mg

time 6: 50mg caffeine 20mg codeine phosphate

time 9: Pure codeine, study end, bed time.


Famotidine increases absorbtion of the drug to avoid a crash, but when crash is imminent, caffeine potentiates amphetamine and codeine eases the crash adverse effects.

I've gotten a college degree doing this dude, done it at least 300 times. It works well for me.

 

[DoctorNinja]

If you potentiate with famotidine HCl first, you get huge high, to the point where you can't focus on your study anymore. The high can be an ich to your genitals pushing you to masturbate, overall euphoria where you hyperfocus on thoughts of greatness and fame, etc. and then you get a crash few hours later. That's mismanagement.

However, if your stomach is too acidic, taking thums does not count as potentiation, it's simply treatment in order to feel the benefic effects of the drug. I've tried Nexium too. I found it was weaker then famotidine HCl although advertised otherwise. The onset for famotidine is within 5-10 minutes after administration, incredibly fast acting. Thums or other antacids are short acting and much much weaker. When I take famotidine, Jesus...lol It's a proton pump inhibitor.

 

[themerv]

does taking magnesium before the amphetamine affect any of the "high" and the effectiveness of the drug?

i know partially blocks the NMDA Ca2+ channels which is involved developing tolerance.

secondly, does it matter that much if you take the magnesium before or after?
i dont know what the general consensus is on taking magnesium after the amphetamine wears off.

also i tried the tums (anatacid with calcium bicarbonate) -- didnt really improve that much. Would baking soda (sodium bicarbonate) even be much of an improvement?

thanks again for all responses

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