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Ketamine salts solubility

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Ho-Chi-Minh said:
Which sterioisomer of amphetamine is considered more toxic?
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D-amphetamine, to the best of my knowledge DAT mediated uptake is linked to toxicity and it has a far greater affinity for that transporter than L-amphetamine. For reasons that only kind of make sense the NE system is durable as hell so NET uptake doesn't really cause any damage to the nerve terminals.

Granted I don't know how relevant if at all that would be in humans/anything outside a Petri dish.
 
EtOH is such a goddamn dirty drug. Is there anything it doesn't interact with?
 
The great thing about EA is he's extremely knowledgeable, has a sense of humor, is helpful, AND is humble.

No hate towards the other mods/titans of add though, and special shout-out to seker the wrecker.

I wonder why in that study though the author didn't conclude the same about mixed amp salts. I was always under the impression that they're more effective for attention disorders than the piperazine-derived ones.

Also, why don't they use diethylpropion and phenmetrazine for attention disorders, as they have less potential for abuse and have more adrenergic and ne activity than their phenylethylamine-related counterparts?

And if cathinones are primarily releasers as Ebola said then why is bupropion basically strictly an ndri?

Feel free to correct anything I said.
 
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And if cathinones are primarily releasers as Ebola said then why is bupropion basically strictly an ndri?
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There are *always* exceptions. Usually, empirical observations of activity take precedence over assuming it "should" be a resleasing agent.

diethylpropion and phenmetrazine for attention disorders, as they have less potential for abuse
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Ask the Beatles about that one - esp. phenmetrazine.
 
1. Varenicline is a partial agonist at nicotinic receptors, so full agonists might not share this property and
2. the relationship between nicotine and alcohol consumption might differ between those with alcohol dependence and those without alcohol dependence. Anecdotally, we can refer to people who take up chain-smoking while beginning AA.

ebola
 
Ho-Chi-Minh said:
The great thing about EA is he's extremely knowledgeable, has a sense of humor, is helpful, AND is humble.

No hate towards the other mods/titans of add though, and special shout-out to seker the wrecker.

I wonder why in that study though the author didn't conclude the same about mixed amp salts. I was always under the impression that they're more effective for attention disorders than the piperazine-derived ones.

Also, why don't they use diethylpropion and phenmetrazine for attention disorders, as they have less potential for abuse and have more adrenergic and ne activity than their phenylethylamine-related counterparts?

And if cathinones are primarily releasers as Ebola said then why is bupropion basically strictly an ndri?

Feel free to correct anything I said.
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Awe thanks bro :) But lets not forget some of the ADD veterans like nuke, ebola?, the various Hamms, and some of the up and comers like gaius and cannibalsnail.

Bupropion is (according to my old British neuropharmacology prof) a NDRI likely because its too bulky to be transported into the cell via DAT/NET. This is the same logic some drug companies had when creating methylphenidate "yo bro lets make this amphetamine backbone bulky as hell and possibly charged so it can't diffuse through the membrane, that'll probably block catecholamine reuptake".
 
And if cathinones are primarily releasers as Ebola said then why is bupropion basically strictly an ndri?
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My point was actually that cathinones relatively close to the cathinone skeleton itself tend to be releasers. Put some bulk on that alpha-chain, and you wander into reuptake inhibition instead. I think that EA's explanation is sound, but I still wonder why alpha-substitutions tend to abolish releasing activity more effectively than ring-substitutions.

ebola
 
There is probably an undiscovered mechanism against depression. I know, it may be due to trpa receptors, but I don't think so. Just read the abstracts please/concluding sentence of each. I'm trying to find out why it has antidepressant effects. I could do more research but I already typed this twice and I'm sick as a dog. Thanks.

http://www.biomedsearch.com/nih/Antidepressant-like-effect-Delta9-tetrahydrocannabinol/20332000.html

http://www.biomedsearch.com/nih/Inhibitory-effect-cannabichromene-major-non/22300105.html

http://www.biomedsearch.com/nih/cannabinoid-TRPA1-agonist-cannabichromene-inhibits/23373571.html

http://www.biomedsearch.com/nih/Non-psychoactive-cannabinoids-modulate-descending/20942863.html

http://www.biomedsearch.com/nih/Pha...on-natural-constituent-Cannabis/20619971.html
 
^^^^^
very nice.

I think that we should establish a norm in here that each post should contain at least a little description and commentary (even just a couple sentences) in addition to the link. I think that this would pique more vigorous discussion.

ebola
 
So many amphetamine pro-drugs! So few in use!

CEO of Shire wakes up one day with a revelation: "How about we create a drug which is metabolized to amphetamine in the body, but slowly, so that we can patent it as a new, abuse-proof drug and don't have to worry about possible inefficacy!"

Scientist: "they already have those" *lists clobenzerex, benzphetamine, others*

CEO: "well make another one! I want more goddamn money!"

So many phenethylamines/cathinones which are under-utilized.
 
Well, it looks like they finally finished removing me as a mod. It was fun guys!
 
I remember this thread!

We'll miss you nuke! Thank you for your contributions I've enjoyed them over the years.

In other news:

33265433.jpg


:D


ebola? said:
I think that another couple parts of the story are that d-deprenyl is not a common prescription drug, and clandestine syntheses are nonexistent, so scheduling is unnecessary. The DEA typically avoids scheduling compounds when the additional publicity it would give them outweighs the amount of recreational use the regulations would be expected to prevent. Also, deprenyl's typical synthesis involves methamphetamine as a precursor (heh...doing a bit to explain why d-deprenyl was not pursued as a prescription medication).

ebola
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That's a shame. Deprenyl is a rather fine substitute to most of the traditional stimulant medications currently employed in the states.

Still quite attainable through various other means but certainly not available at your local pharmacy.
 
nuke, you've contributed a huge amount to this site and have been a huge asset over the years. Thanks for everything girl.
 
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