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The main 5-HTP (and psychedelics) thread

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BelgianJ

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Joined
Nov 18, 2001
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57
General 5-HTP Thread

Here's a few mushrooms or LSD + 5-HTP combo threads:

one
two
three
four

and a long one and 5-HTP and visual trails.

Snippets and bits may be collected here

original post:

Hello all,

I was wondering has anyone tried 5-HTP with LSD???

LSD-25 acts upon your 5-HT neurons so I was wondering if pre-loading with 5-HTP would affect your trip...

If anyone has tried this please comment bellow.


-- BelgianJ :)
 
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Im going to say no for the same reasons I and many others stated in the previous thread on this subject.
 
I just now found the other posts on the subject....


too bad... even after 2 weeks of not tripping, I still cannot trip out really. I guess more time is required. I wish there was a way to uncondition my mind from controlling my trip so much.
-- belgianJ
 
I would say it does, here's why

5-htp will increase the amount of Serotonin in the synapse.
More serotonin in the synapse = more serotonin receptor binding. Mind you that LSD is a serotonin receptor agonist...

So LSD + 5-htp may lead to a significant increase in 5-ht receptor binding comapared to LSD alone (Properly timed of course)..

Then again, it may not.(Too many variables)
 
The only way to find out would be to take some lsd now and then preload with 5-htp for the next 2-3 weeks before tripping again. I think that it takes multiple dosages of 5-htp to actually raise your mean serotonin level. If you are sick of taking 5-htp and decide to stop preloading half way through, just take the remaining 5-htp in one large dose to catch a buzz. When i took 9 capsules it made me a little relaxed and my vision became softer.
 
Overdosing on 5htp might not be the safest thing in the world, and can certainly lead to some serious nausea.
 
Actually preloading for weeks in advance would be counter productive as serotonin levels would level off and your body would just begin discarding the excess 5-htp.

The only spike in serotonin levels would come on the first day, maybe few days.. If your serotonin levels are lower than normal, then 5-htp can help to maintain a normal level, even after the spike.

Anyway, if you wanted to try this, Id say 100mg 5-htp in the morning and another 50mg in the afternoon, with the LSD in the evening.. I wouldnt go much higher than this with the 5-htp, and I would try LSD of known medium or low potency.. In case it actually does work. :)
 
Sounds like it would work to me. I`ve takin 5-htp before rolling and that deffinately had an effect. And as for dosing high on 5-htp....yea it makes ya nauseas, and the buzz is shitty
 
Is there such a thing as postloading? silverfucked mentioned that 5htp can raise serotonin levels to normal in serotonin-depleted individuals. Normally, the day after 120 mg ecstasy I feel a little sad or whatever but not nearly as ill as I get after taking 2 hits of licuid cid. I dont know if the feeling of dirty skin after dosing is from diminished serotonin levels but if your experimenting you might as well take 100mg 5htp the day after. couldnt hurt, right?
 
On the weekend I decided to take 1 pill, and 1 hit of acid. The acid is some I have had for a while. 1 hit usually gives me only a threshold dose pretty much. I had been preloading with 5htp for 2 days before the trip. The trip was going great, just as you would expect a candy flip to be, untill all the sudden it felt like one side of my brain collapsed. I just got stupid, I couldnt remember anything at all for more then 5 seconds. I became very confused and in retro spect i felt crazy. I felt good, but was definatly feeling crazy, and everyone with me thought I had just taken a hit and flipped my shit or something. It definatly made the trip very diff, and more intense but not in away acid has ever been for me. What happend is something I would never have even imagined happening. So ya, it definatly works for me at least.
 
dude theres so many variables in that story there is no way to conclude that the 5-htp had effect, unless you had taken the same dose of mdma and lsd together before from the same exact batches and without the 5htp
 
I remember reading a trip report on Erowid because I was wondering if 5-htp would reduce anxiety during a trip.
The first couple times (estimated 10) I did acid I never had any problems with it (over a 6 month period). But recently the last 3 times have been a bit hectic; I start to feel guilty like I've done something wrong, my chest feels as if its collapsing, I get real worried about something/anything, and I can't sit still and if I do everything gets progressively worse. So I begin to pace back and forth in my room or wherever I am. I read around and think Xanax (.5 - 1 mg dose) could possibly help my problem but don't have access to any right now and would rather not have to rely on something thats inconvenient for me to get. Which is why I've been kind of curious how 5-htp would effect a trip, I might try it. However I have doubts (which is bad) about trying to trip successfully again. I've been laying off it, I plan on giving it some time because I believe it's simply the point in my life I'm in resulting in this paranoia.

Anyhow, I went back and found the report. It's titled 'Smooth Ride', and he heard somewhere that 5-htp in combination with acid gives the trip a slight MDMA feel. In his post he says: "One thing I noticed was that it was a total positive vibe from start to finish. I attribute this to the 5-HTP." He also stated it wasn't anything like LSD in combination with MDMA (of course). Check up on the report if you want to read his story. Any advice and comments would be appreciated. Peace.
 
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Me and a friend have experienced an increase of effects of lsd and 2-cb when taking 5-htp prior. In both our cases it was unpleasant. It does not seem to increase all the effects evenly.
 
the acid I dropped, I had dropped a few times before, usually one hit was barely enough to get me off. THis time tho I felt crazzzzy like never before, definatly effected it grreeatttly. very much so. I was confused more then you would believe.
 
fromthestars said:
On the weekend I decided to take 1 pill, and 1 hit of acid. The acid is some I have had for a while. 1 hit usually gives me only a threshold dose pretty much. I had been preloading with 5htp for 2 days before the trip. The trip was going great, just as you would expect a candy flip to be, untill all the sudden it felt like one side of my brain collapsed. I just got stupid, I couldnt remember anything at all for more then 5 seconds. I became very confused and in retro spect i felt crazy. I felt good, but was definatly feeling crazy, and everyone with me thought I had just taken a hit and flipped my shit or something. It definatly made the trip very diff, and more intense but not in away acid has ever been for me. What happend is something I would never have even imagined happening. So ya, it definatly works for me at least.
Click to expand...

It sounds it where the E who hit u :) its very common not to remember anying in the last 5 secs when doing E
 
Here is a quote from somewhere I found the day after the trip I had. The 5htp did 100% definatly cause these effects for me. shit I wish somebody would try this and post about it.

" In the Clyde Mood Scale the pretreatment with 5-HTP accentuated significantly only the parameter of adventureness A. This corresponds to clinical signs of abolished depersonalization and derealization. Dl-tryptophane increased significantly the intensity of LSD induced anxiety (J) and LSD induced confusion (C)."


"Pretreatment with 10 g dl-tryptophane exaggerated the psychotic feature of LSD intoxication and led in the cases of two persons to a prolonged psychotic state with marked schizophrenic symptoms enforcing the treatment with phenothiazines."
 
as an interesting note too. I have been preloading with 100mg of 5htp for a few days. The other day I ripped a fairly big toke of dmt, enough to breakthrough normally, and felt practically nothing. about 4% of what I would expect. That has never happened before.
 
Ok well given my own personal experience and experimentation in this issue over the last few weeks, combined with previous experimentation with 5-HTP and it's interaction with other RCs and their effects on my migraines in the last 4 years I can say this.

A post trip dose has the usual sedative effects of any 50mg+ 5-HTP dose with noticable effects (drowsiness, reduced anxiety) evident within 45 to 60 minutes in most subjects
Two fellow psychonauts I know did a post-trip dose recently, one after a T=0:00=100 ug LSD/T=+6:00=300 ug/T=+14:00=100 ug LSD trip and the other after only a 250 ug LSD trip and 50 ug 5-HTP dose. Both mentioned the previously mentioned effects, in addition to elevated canabis sensitivity and a delayed come up when smoking ("psuedo-creeper-shit" as it was coined).

Returning to the subject of pre-loading, however, I have noticed that it can potentiate a reduction in anxiety (perhaps if only through placebo) while definately increasing the dangers of drowsiness if dosing LSD in a less than energetic or outgoing attitude. This has caused a few expereinces where I have completely fallen asleep/navigated the "dreamscape", either until the LSD stimulation overpowered any potentially elevated malatonin secretion or my desire to return to a more material plane withdrew me from internal immersion. The interaction between canabis and the 5-HTP in these experiences I feel, must be addressed, because as it might have been mentioned, the potentiation of effects/echo-roll when combining 5-HTP and MDA/MDMA is evident in a similar fashion when smoking canabis both during and after the LSD trip. This particular interaction/combination I feel warrents further investigation as some heads I have spoken too experience the opposite with canabis making clear acceptance, focusing and appreciation of the LSD mind set.
 
I wish somebody else had the same kind of experience I had. Maybe if I ever see some more lsd I will have a friend take the 5htp before hand.lol
 
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