The behavioural pharmacology of serotonin receptors?

[D_DOOD]

Results of agonism at various receptor sites

anybody knows an online chart or article? something along the lines of -
5-HT1A - mediating antidepressant activity of SSRIs
5-HT2A 5HT2C 5-HT3 - anxiety, wheight gain, insomnia...

 

[BilZ0r]

In regards to SSRIs and serotonin receptors, or every single receptor in the brain?

 

[D_DOOD]

not every single one...just the important ones...please

 

[BilZ0r]

This kind of pharmacological phrenology is pointless. Receptors have different functions in different parts of the brain at different times under different conditions. Case in point, beta-adrenoreceptors can be either wake promoting or sleep-prominting when they're in the pineal gland.

Why do you want to know this anyway?

 

[D_DOOD]

I'm a chem engineering student so most of the pharm stuff I read on the net is comprehensible to me, but alot of bio stuff I don't know because I don't have the academic background...
I'm researching various pharms for my hard to treat depression, and I often wonder about certain agonism at some receptor like what it does or about how actions and proccesses in ion channels are expressed as feelings.

 

[BilZ0r]

Well thats just the point. Processes in ion channels aren't expressed as feelings. That's why behavioural pharmacology has the tendancy to be so stupid. On a slight tangent. You'll often read stuff that says something like "the 5-HT2 receptor effects hormone release" no while thats true, it's probably because it effects dopamine release. Now 5-HT1A receptors will effect 5-HT2 receptor active... and prefrontal glutamate will effect 5-HT1A receptor activity... and prefrontal dopamine will effect prefrontal glutamate... it's all a big circle, you can't just break it down in the way people try to.

Meanwhile this review might be of some help. It's more about nomenclature, but still.

 

[D_DOOD]

thanks!