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Tetrahydropapaveroline, a natural dopamine reuptake inhibitor?

Nagelfar

Nagelfar

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Tetrahydropapaveroline (do a search here and it's postulated to be an opioid), according to WP, it is found naturally in the brain in trace amounts as a "condensation reaction" between dopamine and a metabolite of dopamine.

200px-Tetrahydropapaveroline.svg.png


Interesting to see if this was synthed and tested in larger amounts than it is found endogenously.
 
looks to be too polar to make it past the liver and into the brain, usually one phenolic OH is about all that is tolerated, more and BA goes to shit
 
'THP' is the abbreviation usually given not to tetrahydropapaveroline, but to an isoquinoline by the name of tetrahydropalmatine, its a dopamine antagonist, one of the Corydalis alkaloids, from C.yanhuoso, IIRC, although must be a damn weak antidopaminergic, else not a D2 antagonist, because I have taken it myself a fair few times (bought some 5g and I did not find it produced unbearable akathisia, which any 'respectable' D2 antagonist would do to me, I am EXTREMELY intolerant of this class of drug, almost as must so as I am to alpha2 adrenoreceptor antagonists (in contrast I eat clonidine and tizanidine like a fish gets wet. I LOVE intravenous, or rectal tizanidine on its own even, and I like a lot, to add 50-75 and occasionally up to 100ug of clonidine to a shot of morphine, dipropionylmorphine or dibenzoylmorphine.
 
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