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taking MDAI regularly - DOCTORS ADVICE NEEDED

Brian.Badonde

Brian.Badonde

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Jun 17, 2010
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96
Hey, I like MDAI and I want to start taking it regularly. (a 70mg dose once per week).

MDAI is a pure serotonin releaser. The serotonin causes vascoconstriction (cardio and broncho) and can make you feel sick. And it increases my resting heart rate from 72 BPM to 110+ BPM. A few days after I take it I can wake up in the middle of the night with extreme heartpain that lasts around 30 mins.

Could I take it safely with the following procedure?




2 hours before: Take a 5ht-3 antagonist. This will bind to the 5ht-3 receptor sites. This will prevent the serotonin from making me nauseaous and it will prevent bronchoconsitrction of the lungs. It should also prevent the serotonin from binding at the heart valve 5ht-3 receptor sites, preventing over stimulation of heart.

Now: 70mg MDAI orally.

30 mins after: Take a beta-blocker to keep the heart rate down. Take a small amount of aspirin to thin the blood a little bit.

1 hour after: Take a small Valium (vascodilator). Due to high blood pressure from peripheral vascoconstriction. (remember that I take a beta blocker 30 mins before which drops my heart rate to around 63 BPM).




What do you think? Can you suggest improvements? I want to do this on a long term basis as safely as possible.

Thank you.
 
Last edited:
you are your own self clinical trial! n=1 :\

Attacking the concept from pharmacological standpoint is definately logical. However if such logic always worked we wouldn't need clinical trials.

Interactions would be a one problem, no one has information on the full metabolism of MDAI.

Diazepam + Beta Blockers relatively benign but with MDAI ?? who knows
Only small and clinically unimportant pharmacokinetic interactions occur between most benzodiazepines and beta blockers, but there is limited evidence that some psychomotor tests may possibly be impaired in patients taking benzodiazepines combined with beta blockers.
Click to expand...
Stockleys + 3.Hawksworth G, Betts T, Crowe A, Knight R, Nyemitei-Addo I, Parry K, Petrie JC, Raffle A, Parsons A. Diazepam/β-adrenoceptor antagonist interactions. Br J Clin Pharmacol (1984) 17, 69S–76S.

also does MDAI somehow stimulate alpha-adrenoreceptors (even downstream) in which case the interaction between cocaine + beta blockers may become relevant (?dont know enough about this)

http://www.bluelight.ru/vb/showthread.php?t=351046
 
You've still got 5-HT2B agonism that will screw your heart up over time. Coupled with the fact antagonists and agonists will downregulate your receptors with regular abuse. You're going to start taking more to get the same effect quickly.

Also, taking Propanolol will slow your heart down because of adrenaline, not because of serotonin. My intuition tells me that fighting a serotonergic problem with adrenaline is not smart.
 
Brian.Badonde said:
Hey, I like MDAI and I want to start taking it regularly. (a 70mg dose once per week).

MDAI is a pure serotonin releaser. The serotonin causes vascoconstriction (cardio and broncho) and can make you feel sick. And it increases my resting heart rate from 72 BPM to 110+ BPM. A few days after I take it I can wake up in the middle of the night with extreme heartpain that lasts around 30 mins.

Could I take it safely with the following procedure?




2 hours before: Take a 5ht-3 antagonist. This will bind to the 5ht-3 receptor sites. This will prevent the serotonin from making me nauseaous and it will prevent bronchoconsitrction of the lungs. It should also prevent the serotonin from binding at the heart valve 5ht-3 receptor sites, preventing over stimulation of heart.

Now: 70mg MDAI orally.

30 mins after: Take a beta-blocker to keep the heart rate down. Take a small amount of aspirin to thin the blood a little bit.

1 hour after: Take a small Valium (vascodilator). Due to high blood pressure from peripheral vascoconstriction. (remember that I take a beta blocker 30 mins before which drops my heart rate to around 63 BPM).




What do you think? Can you suggest improvements? I want to do this on a long term basis as safely as possible.

Thank you.
Click to expand...
I think thats dumb and you'll end up a different person mentally then you were before. I know this for fact and think its the most retarded thing one can do to themselves (take mdxx everyday)
 
with all those negative side effects you noted, how can you say "i like mdai and want to take it regularly" ???

treat it like any other serotonin releaser and keep it to once a month. preferable to go once every three months.

we don't want you to become a statistic in the determination of MDAI's lethality, and also consider that ALL MDAI on the market is one of three possibilities: 1) intentionally cut with random compounds for higher profit; 2) unintentionally impure by nearly 50% with god knows what; 3) not MDAI at all.

please be safe. if your body is telling you that the drug is damaging your heart, i think you should listen. it sounds like you have an addiction-biased personality and really need to look forward to your "friday night binge" in order to get through the week. i suggest you get some support from friends who do not need to get spun out of their minds on a schedule. save these special drugs for times that are truly special, instead of trying to make every weekend into fear and loathing.
 
You are having a spectrum of side effects from MDAI which are extremely unusual - at low doses (70mg) it should not significantly increase you heart rate, cause chest pain, vasoconstriction, or make you nauseous. If you are not aware certain samples of MDAI have been analyzed and found to be mephedrone - I advise you to test your material with a Marquis reagent or whatever else you have at your disposal.
 
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