Taking GABA whilst on opiates

[Bad_Boy_Blue]

Since GABA inhibits the firing of dopamine in dopaminergic neurons and opiates activate the presynaptic opioid receptors on GABA neurons, inhibiting the release of GABA and indirectly causing dopaminergic neurons to fire more vigorously, would suplementing with GABA while under the influence of opiates destroy your high?

 

[bouncer]

GABA doesn't cross blood-brain-barrier - meaning it won't work as you say. There's Picamilon - supplement which contains GABA+niacinamide (FWIR) - maybe try with that. Or with GHB/Phenibut.

 

[Rcin]

Well like bouncer said GABA won't work like you say, but something else like Benzodiazapines or Alcohol that interacts with GABA receptors would over depress your brain to the point of unconciousness our death perhaps. Just a bad idea in my opinion.

 

[Tialis]

But a small percentage of GABA must pass the BBB, otherwise it wouldn't give any effect, which it does.

 

[PhorIndicator]

So would that mean that benzos are alcohol would destroy an opiate high? According to the original poster's statement, it would suggest this, it seems..... :/

 

[BilZ0r]

But a small percentage of GABA must pass the BBB, otherwise it wouldn't give any effect, which it does.

Well... yes and no. There is no evidence that large oral doses of GABA (5g+) has an effect on the brain. But saying that that is due to it getting into the brain is a bit jump. For instance, a small injection of adrenaline will cause the brain to activate a sympathetic response, and in suscpetable people, might cause a full-blown anxiety attack. Is this caused by adrenaline getting into the brain? Absolutely not, it's caused by the brain reacting to altered sensory input.

Since GABA inhibits the firing of dopamine in dopaminergic neurons and opiates activate the presynaptic opioid receptors on GABA neurons, inhibiting the release of GABA and indirectly causing dopaminergic neurons to fire more vigorously, would suplementing with GABA while under the influence of opiates destroy your high?

This conventional wisdom is probably massively oversimplyfied. Benzos massively potentiate GABA action, but still cause an increase in dopaminergic cell firing rates... likewise muscimol, a direct GABA-A agonist.

 

[Tialis]

This conventional wisdom is probably massively oversimplyfied.

Can you give us a better, more detailed explanation?

 

[fungus44]

^^^ As a non-scientist, the way I understand it is that some neurotransmitters (like GABA) or their precursors (l-dopa) will sometimes cross the blood brain barrier in some people. While most people will ot getting manic or euphoric from l-dopa it does occur in a significant minority of people.

Perhaps the scientists could explain some of the role GABA plays in the autonomic nervous system as opposed to the CNS.

 

[blase deviant]

Well... yes and no. There is no evidence that large oral doses of GABA (5g+) has an effect on the brain. But saying that that is due to it getting into the brain is a bit jump. For instance, a small injection of adrenaline will cause the brain to activate a sympathetic response, and in suscpetable people, might cause a full-blown anxiety attack. Is this caused by adrenaline getting into the brain? Absolutely not, it's caused by the brain reacting to altered sensory input.

Yes. I was thinking of getting some GABA even though it doesn't cross the BBB, because I remember reading in an anti-anxiety book "A relaxed mind makes for a relaxed body, and you cannot have a relaxed mind in an unrelaxed body" or something like that, in regards to relaxing your muscles, deep breathing, posturing yourself as relaxed... etc.

So I figured if it were cheap enough it might be worth looking at.

In regards to the original question, if you were high on some sort of dope and your body were more relaxed, you might feel better/more high. I dunno.

Semi on-topic, I've always wondered if benzos + amphetamines mimicked the effects of opiates. You'd be firing more dopamine, but less often, since the benzos suppress firing...

 

[BilZ0r]

Can you give us a better, more detailed explanation?

Well, the idea that Mu opioid receptors inhibit GABA release in the Ventra tegmental area (VTA) is fine enough... disinhibition of dopaminergic cells, more dopamine. But then you look at benzos, barbiturates and muscimol: GABA-A agonists and potentiators. These compounds should shut down dopaminergic firing, but they don't, they increase it.

 

[Dr. Beat]

On the weekend i tried 15mls of methadone a friend gave me, and about the 6 hours mark i was getting very high and scattered (felt like LOTS of dopamine releasing with a slight lowering of seratonin probably due to low blood suger) and was going to a house party and was going to be on public transport for 2 hours, and thought I cannot be this high and manic on the train, so i took Baclofen 10mg and when it hit (about 1 hour later) it took away ALL my high for the rest of the night and made me very calm and serious.

So i googled and found this:

http://opioids.com/heroin/baclofen.html
http://opioids.com/heroin/heroinnac.html

I will try methadone and a benzo (like rohypnol) next time and post the results.

I have also tried methadone a few weeks ago, and at the 6 hour mark taken mirtazapine to calm me down and that worked REALLY well. Awsum combo with a few nicotine lollies.