Benzos tagamet, temazepam and benzos

[laCster]

finally got my hands on 30mg temaz capsules (fuck yes!), and im stoked because i've only heard rumors of the euphoric stupor it provides and not actually gotten to see from first hand experience if this is true.

so my questions are, is temazepam metabolized through 3A4 thus being potentiated by tagamet and other enzyme inhibitors? also, which would be the better combination in terms of recreation in your opinion, xanax and temaz, or klonopin and temaz? any other input concerning HR and temazepam would be greatly appreciated

thanks,
-lac

 

[Psychonauticunt]

Is temazepam metabolized through 3A4 thus being potentiated by tagamet and other enzyme inhibitors?

No. Temazepam, like the rest of the 3-hydroxy group of benzodiazepines, is metabolized through conjugation and does not rely CYP3A4 - accordingly, its metabolism is unaffected by inhibitors of that enzyme.

Which would be the better combination in terms of recreation in your opinion, xanax and temaz, or klonopin and temaz?

Xanax. It is stronger, kicks in quickly (as does temazepam - clonazepam takes a while), and is more strongly anxiolytic than clonazepam. Clonazepam is a stronger muscle relaxant than alprazolam, but temazepam also has decent muscle relaxant properties. Alprazolam simply adds more to the equation than clonazepam.

 

[laCster]

thanks, i am going to switch out kpin for xanax and even though the the tagamet wont potentiate the temaz, it will still boost the effects of my suboxone and xanax

this is not a pill id question, but if i have temaz capsules, does that mean that the temaz i have is XR?

 

[Psychonauticunt]

thanks, i am going to switch out kpin for xanax and even though the the tagamet wont potentiate the temaz, it will still boost the effects of my suboxone and xanax

this is not a pill id question, but if i have temaz capsules, does that mean that the temaz i have is XR?

No. There is no extended release formulation - as a hypnotic with short to intermediate action, a single dose of the drug is meant to be absorbed quickly to induce sleep, and exert its primary effects over 6-8 hours, preventing premature awakenings.

 

[laCster]

thank you very much, this is what i thought, but my naive friend tried to tell me otherwise

about to take .25mg of kpin as 30mgs temaz and .5mg xanax isnt holding me over

 

[THC2LSD]

finally got my hands on 30mg temaz capsules (fuck yes!), and im stoked because i've only heard rumors of the euphoric stupor it provides and not actually gotten to see from first hand experience if this is true.

It's one of the better benzos, but don't expect something like Quaalude.Expect something more like Xanax or Valium. Kind of weak, though the buzz is nice once you take about 60mg or more. And it's the best sleeping pill I've tried. It's not particularly sedating, it's about like most benzos. Seems more to relax you to sleep.

Those Normison gelcaps the rest of the world gets are supposedly much better than Restoril, particularly IV. Although IV's a bad idea, especially since they put the anti-abuse shit in it or they're counterfeits made god know how.It's very hard on the veins, and people have lost limbs by accidentally shooting it into an artery.

 

[kokaino]

Is temazepam metabolized through 3A4 thus being potentiated by tagamet and other enzyme inhibitors?

No. Temazepam, like the rest of the 3-hydroxy group of benzodiazepines, is metabolized through conjugation and does not rely CYP3A4 - accordingly, its metabolism is unaffected by inhibitors of that enzyme.

Which would be the better combination in terms of recreation in your opinion, xanax and temaz, or klonopin and temaz?

Xanax. It is stronger, kicks in quickly (as does temazepam - clonazepam takes a while), and is more strongly anxiolytic than clonazepam. Clonazepam is a stronger muscle relaxant than alprazolam, but temazepam also has decent muscle relaxant properties. Alprazolam simply adds more to the equation than clonazepam.

While temazepam is a stronger sedative and muscle relaxant than both clonazepam or alprazolam, I wouldn't say that alprazolam is stronger than clonazepam. I think their sedative properties are roughly equal. Clonazepam is a much more powerful anticonvulsant and muscle relaxant than alprazolam. They are equally good anxiolytics, in fact, clonazepam might be the better one overall due to various reasons.

 

[kokaino]

It's one of the better benzos, but don't expect something like Quaalude.Expect something more like Xanax or Valium. Kind of weak, though the buzz is nice once you take about 60mg or more. And it's the best sleeping pill I've tried. It's not particularly sedating, it's about like most benzos. Seems more to relax you to sleep.

Those Normison gelcaps the rest of the world gets are supposedly much better than Restoril, particularly IV. Although IV's a bad idea, especially since they put the anti-abuse shit in it or they're counterfeits made god know how.It's very hard on the veins, and people have lost limbs by accidentally shooting it into an artery.

Yes, Restoril is the worst temazepam brand despite the fact that they come in 30 mg doses. The 20 mg Normisons are way better as are many of the European tablet forms.

 

[DubNaut]

cool, will cut the 200mg Cimetidine in half
will be trying 100mg with 1mg clonazepam and 1-2 mg etizolam.

or should i just take the full 200?

 

[tricomb]

Yes, Restoril is the worst temazepam brand despite the fact that they come in 30 mg doses. The 20 mg Normisons are way better as are many of the European tablet forms.

Worst in what way? What about the countless generics of 30mg temazepam in the USA.

I've had quite a few generics of the 30mg capsules (which, lacster, are just powder... no time release ) and I don't think they were better than the 20mg Normisons.

It would be nice if we had tablet form in the US.

 

[kokaino]

Worst in what way? What about the countless generics of 30mg temazepam in the USA.

I've had quite a few generics of the 30mg capsules (which, lacster, are just powder... no time release ) and I don't think they were better than the 20mg Normisons.

It would be nice if we had tablet form in the US.

All the North American temazepam generics and Restoril pale in comparison to the Normisons or the tablet forms. Thanks to online pharmacies I have been able to try tablets and Normisons and I especially like the really small white tablets. I can start feeling the drug within 15 minutes and it intensifies as it reaches the 30 minute mark and by the hour mark it is pretty much near its peak. Another good brand of temazepam is Hypnotil, which I believe is a South Asian brand.

I find the North American brands of temazepam are really hampered by the capsules. Personally, for me I don't have this issue because I do start feeling it at the 30 minute mark after ingestion, but there are some that complain that the onset drags on - which is very strange since temazepam is a very rapid acting benzo. It's definitely the brands and the capsules IMO. The best solution to this is to open the capsules up and pour the powder in a little glass of wine and just shoot it back real quick or parachute it with a thin piece of tissue or something. When I do this I usually start feeling the effects within 10 minutes.

Temazepam pharmacokinetics (based on a study done by the FDA):

After oral administration, temazepam is rapidly absorbed and fast acting. Following ingestion of 30 mg temazepam, measurable plasma concentrations are achieved 10-20 minutes after dosing with peak plasma levels ranging from 666-982 ng/mL (mean 865 ng/mL) occurring approximately 1.2-1.6 hours (mean 1.5 hours) after dosing. Strong hypnotic, sedative and anticonvulsant effects are noticeable 20-30 minutes after ingestion.

 

[tricomb]

I've always felt capsuled temazepam in 15 minutes without tampering with the capsule. The capsule literally disintegrates very rapidly on contact with moisture, so I'm not convinced that the capsule significantly delays the time of onset.

 

[kokaino]

I've always felt capsuled temazepam in 15 minutes without tampering with the capsule. The capsule literally disintegrates very rapidly on contact with moisture, so I'm not convinced that the capsule significantly delays the time of onset.

That's actually true. I'm really at a loss as to why the North American brands of temazepam suck compared to the European and Australian brands. I swear to god a 20 mg Normison is stronger than a 30 mg Restoril, at least in my experience. I've heard similar things from others. Don't get me wrong - Restoril is still great and probably the best benzo on the US market, but for some reason it just doesn't measure up to its European counterparts.

 

[xxxyyy]

i've had temazepam prescribed for a while, in 20mg gel capsules. they were gppd for sleep but not much else besides. in the recreational deparment i found them completely lacking and alprazolam is much better in any case, unless you just need a good nights slep.

 

[laCster]

^ i feel completely opposite. temazepam is the most euphoric and recreational benzo IME,

i ran out of my temaz, all i got is xanax and klonopin left

 

[kokaino]

^ WoW xxxyy, you're definitely in the minority here.

Temazepam is the benzo which caused a mass epidemic across two continents - there was a damn good reason for it too. It's absolutely the best benzo hands down!

Xanax is boring.

 

[laCster]

xanax is...wellll....idk what it is because i dont want to say boring because it is a benzo and there are alot more boring drugs out there IME. it doesn't come with much else besides relaxation which is goood.

i definitely don;t think xanax is boring when combined with other drugs. amps and xanax, opiates and xanax, ect... it adds a a warm feeling and contributes to the anxiety IMO

this is not good HR, don't try this at home kids

Bro, if its not HR dont post it. -TC

 

[tricomb]

That's actually true. I'm really at a loss as to why the North American brands of temazepam suck compared to the European and Australian brands. I swear to god a 20 mg Normison is stronger than a 30 mg Restoril, at least in my experience. I've heard similar things from others. Don't get me wrong - Restoril is still great and probably the best benzo on the US market, but for some reason it just doesn't measure up to its European counterparts.

Yeah I want the tablets and gels to be marketed in the US so bad, I'd replace my Restoril RX for the tabs and gels.

 

[kokaino]

Xanax does its job and it does it well (relieve bad anxiety), but other than that it is really nothing special. It is a very very weak muscle relaxant, weak anticonvulsant and mediocre sedative. It has no real value besides its powerful anxiolytic properties.

 

[kokaino]

Yeah I want the tablets and gels to be marketed in the US so bad, I'd replace my Restoril RX for the tabs and gels.

Oh the gelcaps are a thing of the past. The only country that still carries the "eggs" is the Netherlands and they only come in 20 mg and are listed as List I under the "Opium Law". That means they are scheduled alongside morphine, heroin, cocaine, methamphetamine, hydromorphone etc. I think Australia might still have it, but it is generally not prescribed.

The UK definitely doesn't got them no more. They only carry the tablets now. In the United Kingdom, midazolam and temazepam are Schedule III controlled drugs. British law requires temazepam (but not midazolam) to be stored in safe custody. Safe custody requirements ensures that pharmacists and doctors holding stock of temazepam must store it in securely fixed double-locked steel safety cabinets and maintain a written register, which must be bound and contain separate entries for temazepam and must be written in ink with no use of correction fluid. Disposal of expired stock must be witnessed by a designated inspector (either a local drug-enforcement police officer or official from health authority).