Suzetrigine is a non-opioid, small-molecule analgesic that works as a selective inhibitor of Nav1.8-dependent pain-signaling

[LucidSDreamr]

Suzetrigine is a non-opioid, small-molecule analgesic that works as a selective inhibitor of Nav1.8-dependent pain-signaling

Vertex pharma is getting lose to approving this drug. Anyone tried it and can anyone comment on the mechanism of action as being possible an effecting analgesia?

The phase two trial shows no improvement over placebo but chronic pain is sort of becoming an orphan disease now that opioids are de facto banned in western medicine; so I would not be surprised if it gets rammed through. It wouldn’t be the first time drugs with such mediocre trial results received approval. They are also talking about redesigning the phase z3 trial to get the results they “want” (ie it improved pain).

Check the Wikipedia page for reference r the pharmacological action.

 

[bob_arctor]

now approved

 

[LucidSDreamr]

now approved

I’m wondering if this drug causes dependency. It apparently only acts at peripheral neurons mainly so I would think no? It is a ion channel targeting drug Ala benzos and gabaergics so I wonder if dependency is possible