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Super Brew - Ayuhasca + Cacti extract... is this safe?

motiv311

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My friends have been buggin me to hook them up with some of "that weird shit you buy on ebay" (cacti and ayuhasca) which i have bought and made for them before. The first time i bought cactus and we ate it all up, we were kind of dissapointed with the results - although we did feel something. The ayhuasca actually worked, and we cant really put all the detailes together of what actually happened, but it worked. So I am thinking of making a super brew using : a 1/2 pound of dried pachanoi powder, and adding a moderate portion of of Ayuhasca with special care to the amount of Harmala (maoi) that i include. I am going to use reverse Ph double-layer extraction of the Cacti.

Is this safe?
 
Probably not. San Pedro contains tyramine related phenethylamines that act as pressor agents (increase blood pressure). These are normally inactivated by gut MAO - inhibit it with harmala alkaloids & there's a good chance of your blood pressure noticably going up.

From what I've read, you can combine competetive MAOIs like harmala alkaloids with smaller doses of mescaline, but San Pedro doesn't just contain mescaline...
 
I didnt mean specifically San pedro. I was actually planing on using dried peruvians incense (which i hope contains the alkoloids) . Im sure ill pick a pretty good one. I have a knack of discerning bullshit artists from good ebayers.
 
i know this is a redundant question, but what is the most practical cacti to use for this sort of an experiment?
 
Actually, I know someone that took a full dose of san pedro with an unknown amount of plant matter containing harmala alkaloids.

He said he vomited profusely, and it felt like someone was compressing his head in a vise. I can't remember exactly how he described it.. something about how it felt like there was so much pressure in his head it felt like his eyeballs were goign to rupture, or his head was going to crack open and that a migraine was a fart in the wind by comparison.

not a great idea.
 
He said he vomited profusely, and it felt like someone was compressing his head in a vise. I can't remember exactly how he described it.. something about how it felt like there was so much pressure in his head it felt like his eyeballs were goign to rupture, or his head was going to crack open and that a migraine was a fart in the wind by comparison.

A pretty good description of what sounds like the beginning of a hypertensive crisis
 
Ayahuasca like combo in cacti

i doubt there is one that can be used safetly, as previously stated

Shulgin will report many in his next book. He mentioned in Basel the Pachycereus pringlei as extraordinary peychedelic, although none of its components are active by itself. It must be the combination which probably act as a ayahuasca. Many of the present IQs are MAOIs and they obviously make the PEAs active.
I just had a look in Shulgins isoquinoline book and attached the formulae of the present compounds.

Nevertheless I suppose a lot of sideeffcts from such a brew.
 

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i've done dmt(freebase, smoked) many times while on mescaline. its too heavy for many, trust me!

i think aya would be fine after taking mescaline, but not pedro tea, that sounds like a formula for puking
 
i think aya would be fine after taking mescaline

Pure mescaline (synthetic) as opposed to mescaline & other alkaloids from any cactus source. Also the dose of pure mescaline would be considerably smaller (60mg with harmala alkaloids being equivalent to 300-400mg on its own).

REMEMBER. The chances of getting synthetic mescaline from any dealer (basically anybody other than the synthetic chemist responsible for it) are next to zero; it's most likely be a 2C-X being called mescaline to make it sell and a 2C-X in combination with harmala alkaloids is a trip to a hospital emergency dept just waiting to happen.
 
REMEMBER. The chances of getting synthetic mescaline from any dealer (basically anybody other than the synthetic chemist responsible for it) are next to zero....

I guess that must just be the market or the fact that so much is required per hit? I wouldn't have thought M would be too difficult to synthesize. Gallic acid is easily available and fairly inexpensive, and OTC routes exist to produce the methoxy ethers and the nitro-condensation....

I was given what was claimed to be a dose of M in NZ some 25 years ago. That trip was one of the profound things I've ever experienced.
 
Bit of both really. Mescaline isn't difficult to synthesize at all - there are several usable routes to mescaline, it's just that anything with a 3,4,5-trimethoxy substitution pattern is pretty likely to set alarm bells ringing unless you've got a totally kosher front for ordering it. Combine that with the fact that at best you only get 3 doses from a gram and that the monitored reagents used for some routes (eg lithium aluminium hydride) could be used to make compounds that produce many more doses from a gram via a similar synthetic route (eg DOM at 300 doses/g) and you get very few clandestine chemists going for mescaline synthesis.

This produces a drug with a demand that outstrips supply by orders of magnitude (hence silly prices are thrown around); as you know, whenever that happens, then sharks will appear to rip people off, and with the availability of 2C-X compounds in the last few years the chances of something being sold as synthetic mescaline actually being mescaline are as rare as hen's teeth.

You might get the odd flush of mescaline from plant sources, but again the demand is so great that anyone doing that generally only does enough for friends to buy some. So unless you know the person with the cactus abbotoire, you'll not come across any.

25 years ago, when all the 2C-x's were just as rare and exotic, something said to be mescaline would have a reasonable chance of actually being what it was claimed to be as the only other psychedelics commonly available (to the dodgy little fucks who try to pull off such frauds) that could be substituted were LSD & psilocybin, which are really easy to distinguish from mescaline (although some sharks back then did try with things like 'microdot mescaline' and other obvious frauds).

My first mescaline was from a piece of cactus that had broken off and naturally dried from a T. pachanoi in the university greenhouses (lost at least half a pint of blood sneaking the bloody thing out!) and was so different from psilocybin & LSD that once you'd tried it you'd never be fooled by a tryptamine/ergoline. Since then I've become the Pol Pot of Trichocereus cacti!
 
I guess LiAlH4 and even borohydrides are difficult to obtain for most people, but as for the 3,4,5 trimethoxy pattern, if one started from gallic acid, the trimethoxy moiety could be made relatively easily. I'm surprised we don't hear of anyone making hydrides. They might be difficult to prepare, but the black market value would be considerable. Some are easier to prepare than other of course, and with Li hydrides there's always the required supply of Li to deal with. That is unless you're situated on top of a deposit of spodumene, or care to extract it from natural brine....


More OT: I have never experienced quite what I got from the supposed M, with Trichocereus pachanoi. We used to boil up the inner layers and the syrupy liquid was consumed. The early times involved condensing the liquid so a half a cup was quite potent, but people got lazy and just brewed it like a tea - then often proceeded to drink liters of the stuff. At one time, it seemed everyone in town had a flagon or two of cactus extract lying around.

A rather awful thing occurred in our rather small town. At ~ age 17 I made the discovery (Hallucinogenic Plants - A Golden guide - by R. Evans Schultes & Elmer W Evans) that san pedro contained mescaline, and word spread quickly. But apart from a few unnoticed specimens in back yards, the only san pedro everyone knew of was the one that greeted all who drove into town. It was a majestic thing, some 12 or more feet high, with large thick branches. I remember it from my first recollections of travelling in a car. First the branches went, then the trunk, hacked off with machetes and axes, and within a month it was all but gone. From that point on, the distances people had to drive to find it got further every day :(


HALLUCINOGENIC PLANTS
by RICHARD EVANS SHULTES
Illustrated by ELMER W. SMITH

GOLDEN PRESS - NEW YORK 1976
Western Publishing Company, Inc.

pp 100-112

SAN PEDRO (Trichocerous pachanoi) is a large columnar cactus widely cultivated as a hallucinogen in the Andes of Peru, Ecuador, and Bolivia. The natives, who also call it aguacolla, or giganton, recognize several "kinds," which differ mainly in the number of ribs, the most common type having seven. This cactus is sometimes planted along fields as a fence row to keep sheep and cattle from grazing.

An intoxicating drink called cimora is made from the San pedro cactus. Short lengths of the stem, often sold in native markets, are sliced like loaves of bread and then boiled in water for several hours, sometimes with superstitious objects such as cemetary dust and powdered bones.

Although cimora is often made from San Pedro alone, several field researchers indicate that a variety of other plants may sometimes be added to the brew. These include the cactus Neoraimondia macrostibas, an Andean species the chemistry of which has not yet been determined; the shrub Pedilanthus tithymaloides of the castor oil family; and the campanulaceous Isotoma longiflora. All these plants may have biodynamic constituents. On occasion, other more obviously potent plants are added - Datura, for example.

Only recently have researchers become aware of the importance of the "secondary" plant ingredients often employed by primitive societies. The fact that mescaline occurs in the San Pedro cactus does not mean that the drink prepared from it may not be altered by the addition of other plants, although the significance of the additives in changing the hallucinogenic effects of the brew is still not fully understood.

Cimora is the basis of a folk healing ceremony that combines ancient indigenous ritual with imported Christian elements. An observer has described the plant as "the catalyst that activates all the complex forces at work in a folk healing session, especially the visionary and divinitory powers" of the native medicine man. But the powers of San Pedro are supposed to extend beyond medicine; it is said to guard houses like a dog, having the ability to whistle in such unearthly fashion that intruders flee in terror.

Although San Pedro is not closely related botanically to peyote, the same alkaloid, mescaline, is responsible for the visual hallucinations caused by both. Mescaline has been isolated not only from San Pedro but from another species of Trichocereus. Chemical studies of Trichocereus are very recent, and therefore it is possible that additional alkaloids may yet be found in T. pachanoi.

Trichocereus comprises about 40 species of columnar cacti thot grow in subtropical and temperate parts of the Andes.

There is no reason to suppose that the use of the San Pedro cactus in hallucinogenic and divinatory rituals does not have a long history. We must recognize, certainly that the modern use has been affected greatly by Christian influences. These influences are evident even in the naming of the cactus after Saint Peter, possibly stemming from the Christian belief that Saint Peter holds the keys to heaven. But the overall context of the ritual and our modern understanding of the San Pedro cult, which is connected intimately with moon mythology, leads us to believe that it represents an authentic amalgam of pagan and Christian elements. Its use seems to be spreading in Peru.

http://rapidshare.de/files/1963883/shultes1976guide.zip.html
 

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I have never experienced quite what I got from the supposed M, with Trichocereus pachanoi.

Possibly mescaline & other alkaloids extracted from peyote; it contains a load of isoquinoline alkaloids and has a different feel to the effect of alkaloids from Trichocereus species

But apart from a few unnoticed specimens in back yards, the only san pedro everyone knew of was the one that greeted all who drove into town. It was a majestic thing, some 12 or more feet high, with large thick branches. I remember it from my first recollections of travelling in a car. First the branches went, then the trunk, hacked off with machetes and axes, and within a month it was all but gone. From that point on, the distances people had to drive to find it got further every day

That would have been perfect fodder for the tabloid press:

Drug scum hack down town's pride & joy

You just know the sort of story that would have been written to go with that headline!
 
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