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Benzos sublingual xanax questions. which pills? how efficient?

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MasterPwnage

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Jun 16, 2009
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hey everyone, so i hear people talking about taking their alprazolam/xanax sublingually. i have a few questions about this:

which type of xanax can be taken sublingually? my little brother was once prescribed nirivam, which was just .5mg xanax pills in a sublingual form, they were made specifically for sublingual administration.

i am prescribed to 2mg alprazolam bars. are these able to be taken sublingually also? or does it have to be made specifically for sublingual use.

the 2mg greenstone, purepacs, davas and sandoz bars ya know? if i broke off two quarters and stuck them under my tongue would it work? and if so how well?

i know theres alot of different alprazolam pills. does this also have an effect on its sublingual viability?
 
I would take Xanax orally if it wasn't made for sublingual use. I tried this and it tasted horrible.

This is a pretty basic drug inquiry that I'll move to BDD.

Overall, Xanax should have about the same effect, whether you take it orally or sublingually.
 
Im a bit confused on the whole xanax sublingual question myself (which is odd considering my nearly perfect knowledge of all things drug-related;).

Here is what throws me. Alprazolam is not water-soluble. Things which are not water soluble should, in theory, not be very effective when taken sublingually, correct?

Now, I know that you can plug xanax but that is a bit more complicated. Xanax is fat soluble, and as I understand it, there are receptor-type things in your lower bowel which facilitate the absorption of fat-soluble molecules. So, when you plug xanax, it is absorbed through these "receptors" due to alprazolam's fat solubility.

However, I do not believe there are similar receptors in the mucous membranes under your tongue. Therefore, I would think that non water soluble substances such as alprazolam, would not be effectively absorbed.

Despite all of this, many people seem to take xanax sublingually, and report positive effects. Perhaps I am missing something, or perhaps people are simply swallowing the xanax after taking it sublingually, and the effects they get are from swallowing the xanax, and not from the sublingual aspect.


And to briefly answer the OP's question-it doesnt matter what brand name the pill is. Either alprazolam is effective sublingually or it isn't. The name brand of the pill should not matter, except perhaps some minor differences in absorption due to possible different binders/fillers used by different manufacturers, but as I said, these differences would be negligible.-DG
 
There is always the time released ones, they would be slow to absorb sublingually if they did at all. Quite frankly if you can stand the taste, more power too you. I'd loose my lunch trying to do that. It's like xanax was engineered to taste bad.
 
i take the bars and most of the time i do them sublingual. i would only leave them there for a couple mins because the taste does suck. but it does work. ive found that sublingual works good for the xr's. maybe just me but they dissolve fast and it hits me alot faster than just swallowing.
 
daddy's theory about water solubility and membranes is flawed. im too fucked up to explain why. and whatever you are saying about receptors does not seem right. i know there are neurotransmitter receptors (that what you mean by "receptors"?) in your intestines, MU for example, but i do not believe that they have anything to do with bioavailbility. not to rip on you answer at all though, daddy, you sounds smart and your final answer is correct. it does not matter the brand. if you are patient and can handle not talking or swallowing excessively, not drinking, smoking, brushing your teeth, etc for 15min, sublingual administration without question has a quicker come up and, IME, increases the recreational value of xanax. but i think taking pills sublingually is almost a developed skill, like smoking drugs. i would have beginners or one time users just swallow, unless i knew they had the personality/patience/control that could do it right.

if you have the bars, break them at the pre-divided sections before holding it under your tongue, so your spit dissolves and lets the active substance make contact with the membrane more quickly.
 
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hydroazuanacaine said:
daddy's theory about water solubility and membranes is flawed. im too fucked up to explain why. and whatever you are saying about receptors does not seem right. i know there are neurotransmitter receptors (that what you mean by "receptors"?) in your intestines, MU for example, but i do not believe that they have anything to do with bioavailbility. not to rip on you answer at all though, daddy, you sounds smart and your final answer is correct. it does not matter the brand. if you are patient and can handle not talking or swallowing excessively, not drinking, smoking, brushing your teeth, etc for 15min, sublingual administration without question has a quicker come up and, IME, increases the recreational value of xanax. but i think taking pills sublingually is almost a developed skill, like smoking drugs. i would have beginners or one time users just swallow, unless i knew they had the personality/patience/control that could do it right.

if you have the bars, break them at the pre-divided sections before holding it under your tongue, so your spit dissolves and lets the active substance make contact with the membrane more quickly.
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I think I confused the issue a bit by using the term "receptors". You are of course correct that there are not actual receptors, akin to the ones which neurotransmitters bind to, in the mucous membrane in your lower bowel. I used the term "receptors" because I could not think of a better way of describing the structures which are found in this area.
Essentially, there are structures found there which facilitate the absorption of fat soluble molecules. I referred to them as "receptors" because as I understand it, fat soluble molecules will dock to these structures, and then pass through the mucous membrane of your bowel. There is an actual name for these structures, but I cannot recall it, so I used the term "receptor" in order to describe how they function-however you are correct that these structures are very different from the actual receptors to which neurotransmitters bind.

Moving on, so can anyone explain the mechanism behind how a non-water soluble molecules can be absorbed sublingually. I understand how it can occur in the bowel since there are these special structures, but how can it occur in the mouth where I do not believe such structures exist? Thanks-DG
 
i dont understand the non water soluble working sublingually either.. that would mean they are also active insufflated wouldn't it?
 
^Yes, it goes both ways. These drugs pass just fine through membranes.
 
I can't take xanax being in my mouth for any long than a couple seconds, if you can actually leave it under your tongue and wait for it to dissolve, you've got a tongue made from steel.
 
BollWeevil said:
^Yes, it goes both ways. These drugs pass just fine through membranes.
Click to expand...

Ok, can you please explain how a non water soluble drug can pass through mucous membrane? If the drug can not dissolve in the water-based environment of a mucous membrane (such as under your tongue), how then can it pass through the membrane?-DG
 
^why do you think a chemical has to be dissolved in water to pass through a membrane?

if you want a better scientific understanding of how drugs interact with the different membranes in your body, bluelight's other drugs forum may not be source to consult. if you wanna know what works, you are in the right place.
 
hydroazuanacaine said:
^why do you think a chemical has to be dissolved in water to pass through a membrane?

if you want a better scientific understanding of how drugs interact with the different membranes in your body, bluelight's other drugs forum may not be source to consult. if you wanna know what works, you are in the right place.
Click to expand...

Well there are several reasons I think this, but before I go into them, I'd like to provide a link to another thread in ADD where some of the more knowledgeable members of bluelight discuss this subject, and seem to state that its common sense that a non water soluble drug like aplrazolam will not be absorbed through the mucous membrane (of your nasal canal in this case).

http://www.bluelight.ru/vb/showthread.php?t=483379

Read the last few posts. They certainly seem to feel that alprazolams lack of solubility in water preclude it from being absorbed.

Now- I am completely open to the chance that I am wrong and would actually like for someone to explain how a non water soluble drug would be able to pass through the mucous membrane of your nose/mouth. As I said in my earlier post, I understand how fat soluble drugs like alpraz can be absorbed rectally, but that is because there are special structures in your lower bowel which facilitate the absorption of fat soluble molecules. I do not believe such structures exist in the mouth/nasal cavity.-DG
 
HdoubleODeezy said:
i dont understand the non water soluble working sublingually either.. that would mean they are also active insufflated wouldn't it?
Click to expand...

Maybe not all of them but there are some drugs you can use sublingually or insuffulated and it's non water soluble. Triazolam is a good example. I tried 0.25mg sublingually, and it worked nicely. :D

As to the "why/how" I'll let someone else fill us in. It's often been said that you can't snort non-water soluble drugs...and I know that's partially true for at least some drugs (like how snorting crack won't get you high I am sure) but I think it's just a rule of thumb not to be true 100% of the time. That's my gut feeling about it, but as I said, I'll let someone else fill us in.
 
This is just me kinda thinking out loud, so I could be completely wrong. If so, feel free to punch me in the mouth

But is water-solubility the sole factor in determining if something can be sublingual'd? Cause saliva might be 98% water, but there's still 2% other shit. Could that affect it?
 
Desdenova said:
This is just me kinda thinking out loud, so I could be completely wrong. If so, feel free to punch me in the mouth

But is water-solubility the sole factor in determining if something can be sublingual'd? Cause saliva might be 98% water, but there's still 2% other shit. Could that affect it?
Click to expand...

Yeah there's other factors. What the binder is in the pill could be another factor.
 
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